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IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs
作者: Shimodaira, Kayoko1,2; Okubo, Yoichiro1; Ochiai, Eri3,4; Nakayama, Haruo1; Katano, Harutaka5; Wakayama, Megumi1; Shinozaki, Minoru1; Ishiwatari, Takao1; Sasai, Daisuke1; Tochigi, Naobumi1; Nemoto, Tetsuo1; Saji, Tsutomu2; Kamei, Katsuhiko3; Shibuya, Kazutoshi1,6
关键词: Pulmonary Vascular Remodeling ; Stachybotrys chartarum ; BMP signaling ; BMPR2 ; PCP pathway
刊名: RESPIRATORY RESEARCH
发表日期: 2012-11-17
DOI: 10.1186/1465-9921-13-103
卷: 13
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Respiratory System
研究领域[WOS]: Respiratory System
关键词[WOS]: SMOOTH-MUSCLE HYPERPLASIA ; REAL-TIME PCR ; ARTERIAL-HYPERTENSION ; STACHYBOTRYS-CHARTARUM ; ANGIOGENESIS ; CELLS ; ACTIVATION ; INHIBITOR ; NETWORKS ; DISEASES
英文摘要:

Background: Idiopathic pulmonary arterial hypertension (IPAH) continues to be one of the most serious intractable diseases that might start with activation of several triggers representing the genetic susceptibility of a patient. To elucidate what essentially contributes to the onset and progression of IPAH, we investigated factors playing an important role in IPAH by searching discrepant or controversial expression patterns between our murine model and those previously published for human IPAH. We employed the mouse model, which induced muscularization of pulmonary artery leading to hypertension by repeated intratracheal injection of Stachybotrys chartarum, a member of nonpathogenic and ubiquitous fungus in our envelopment.

Methods: Microarray assays with ontology and pathway analyses were performed with the lungs of mice. A comparison was made of the expression patterns of biological pathways between our model and those published for IPAH.

Results: Some pathways in our model showed the same expression patterns in IPAH, which included bone morphogenetic protein (BMP) signaling with down-regulation of BMP receptor type 2, activin-like kinase type 1, and endoglin. On the other hand, both Wnt/planar cell polarity (PCP) signaling and its downstream Rho/ROCK signaling were found alone to be activated in IPAH and not in our model.

Conclusions: Activation of Wnt/PCP signaling, in upstream positions of the pathway, found alone in lungs from end stage IPAH may play essential roles in the pathogenesis of the disease.

语种: 英语
所属项目编号: H22-Shinkou-Ippan-8 ; H23-Shinkou-Ippan-018 ; 23-19 ; 23-21 ; 23-28 ; 24790364
项目资助者: Pfizer Inc. ; Janssen Pharmaceutical K.K. ; Dainippon Sumitomo Pharma Co. ; Astellas Pharmaceutical Company ; Taiho Pharmaceutical ; Pola pharma ; Ministry of Health, Labor and Welfare of Japan ; Ministry of Education, Culture, Sports, Science and Technology of Japan ; Toho University ; Yokohama Foundation for Advancement of Medical Science ; Toho University Medical School ; Ministry of Education, Culture, Sports, Science and Technology of Japan (KAKENHI)
WOS记录号: WOS:000313954100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55694
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

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作者单位: 1.Toho Univ, Dept Surg Pathol, Sch Med, Ota Ku, Tokyo 1438541, Japan
2.Toho Univ, Dept Pediat, Omori Med Ctr, Ota Ku, Tokyo 1438541, Japan
3.Chiba Univ, Dept Pathogen Fungi, Med Mycol Res Ctr, Chuo Ku, Chiba 2608673, Japan
4.Univ Kentucky, Coll Med, Dept Microbiol Immunol & Mol Genet, Lexington, KY 40536 USA
5.Natl Inst Infect Dis, Dept Pathol, Shinjuku Ku, Tokyo 1628640, Japan
6.Peking Univ, Dept Dermatol, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Shimodaira, Kayoko,Okubo, Yoichiro,Ochiai, Eri,et al. Gene expression analysis of a murine model with pulmonary vascular remodeling compared to end-stage IPAH lungs[J]. RESPIRATORY RESEARCH,2012,13.
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