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IR@PKUHSC  > 北京大学第三临床医学院  > 骨科  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model
作者: Wang, T; Dang, GT; Guo, ZQ; Yang, M
刊名: TISSUE ENGINEERING
发表日期: 2005-07-01
卷: 11, 期:7-8, 页:1159-1167
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell & Tissue Engineering
研究领域[WOS]: Cell Biology
关键词[WOS]: SPINAL-FUSION ; HYDROXYAPATITE ; GRAFT ; DEFECTS ; GROWTH ; BIOMATERIALS ; REGENERATION ; OSTEOGENESIS ; IMPLANTS ; MATRIX
英文摘要:

Autologous bone marrow mesenchymal stem cell ( BMSC) - calcium phosphate ceramic composites were constructed in vitro and implanted as a bone graft substitute for lumbar anterior interbody fusion in rhesus monkeys to determine the osteogenic capacity of the composites. Nine adult rhesus monkeys underwent lumbar L3 - L4 and L5 - L6 diskectomy and interbody fusion via an anterior retroperitoneal approach. Two fusion sites in each animal were randomly assigned to two of three treatments: autogenous tricortical iliac crest bone graft ( autograft group), cell- free ceramic graft ( ceramic group), or BMSC - ceramic composite graft ( BMSC group). Autologous BMSCs were expanded in culture and stimulated with osteogenic supplement. The spinal fusion segments were evaluated by radiography, biomechanical testing, histologic analysis, and histomorphometric analysis 3 months postsurgery. The BMSC group achieved lumbar interbody fusion superior to that of the ceramic group, both biomechanically and histologically. The BMSC group and the autograft group showed equivalent biomechanical stiffness. Ceramic residues were significantly greater in the ceramic group versus the BMSC group. The results indicate that BMSC - ceramic composites can enhance bone regeneration and achieve osseous spinal fusion 3 months after implantation in the rhesus monkey interbody fusion model.

语种: 英语
WOS记录号: WOS:000231959800019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55696
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: Peking Univ, Dept Orthoped Surg, Hosp 3, Beijing 100083, Peoples R China

Recommended Citation:
Wang, T,Dang, GT,Guo, ZQ,et al. Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model[J]. TISSUE ENGINEERING,2005,11(7-8):1159-1167.
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