IR@PKUHSC  > 北京大学第三临床医学院  > 骨科
学科主题临床医学
Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model
Wang, T; Dang, GT; Guo, ZQ; Yang, M
刊名TISSUE ENGINEERING
2005-07-01
11期:7-8页:1159-1167
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell & Tissue Engineering
研究领域[WOS]Cell Biology
关键词[WOS]SPINAL-FUSION ; HYDROXYAPATITE ; GRAFT ; DEFECTS ; GROWTH ; BIOMATERIALS ; REGENERATION ; OSTEOGENESIS ; IMPLANTS ; MATRIX
英文摘要

Autologous bone marrow mesenchymal stem cell ( BMSC) - calcium phosphate ceramic composites were constructed in vitro and implanted as a bone graft substitute for lumbar anterior interbody fusion in rhesus monkeys to determine the osteogenic capacity of the composites. Nine adult rhesus monkeys underwent lumbar L3 - L4 and L5 - L6 diskectomy and interbody fusion via an anterior retroperitoneal approach. Two fusion sites in each animal were randomly assigned to two of three treatments: autogenous tricortical iliac crest bone graft ( autograft group), cell- free ceramic graft ( ceramic group), or BMSC - ceramic composite graft ( BMSC group). Autologous BMSCs were expanded in culture and stimulated with osteogenic supplement. The spinal fusion segments were evaluated by radiography, biomechanical testing, histologic analysis, and histomorphometric analysis 3 months postsurgery. The BMSC group achieved lumbar interbody fusion superior to that of the ceramic group, both biomechanically and histologically. The BMSC group and the autograft group showed equivalent biomechanical stiffness. Ceramic residues were significantly greater in the ceramic group versus the BMSC group. The results indicate that BMSC - ceramic composites can enhance bone regeneration and achieve osseous spinal fusion 3 months after implantation in the rhesus monkey interbody fusion model.

语种英语
WOS记录号WOS:000231959800019
Citation statistics
Cited Times:32[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55696
Collection北京大学第三临床医学院_骨科
作者单位Peking Univ, Dept Orthoped Surg, Hosp 3, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Wang, T,Dang, GT,Guo, ZQ,et al. Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model[J]. TISSUE ENGINEERING,2005,11(7-8):1159-1167.
APA Wang, T,Dang, GT,Guo, ZQ,&Yang, M.(2005).Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model.TISSUE ENGINEERING,11(7-8),1159-1167.
MLA Wang, T,et al."Evaluation of autologous bone marrow mesenchymal stem cell-calcium phosphate ceramic composite for lumbar fusion in rhesus monkey interbody fusion model".TISSUE ENGINEERING 11.7-8(2005):1159-1167.
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