学科主题基础医学
Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury
Yang, Xiao-Yuan1,2; Zhao, Na1; Liu, Yu-Ying1; Hu, Bai-He1; Sun, Kai1; Chang, Xin1; Wei, Xiao-Hong1; Fan, Jing-Yu1; Han, Jing-Yan1,2,3,4
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/728020
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]MYOCARDIAL-INFARCTION ; ISCHEMIA-REPERFUSION ; SALVIA-MILTIORRHIZA ; NAD(P)H OXIDASE ; MICROCIRCULATORY DISTURBANCE ; INFLAMMATORY RESPONSE ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; BLOOD-PRESSURE ; VITAMIN-E
英文摘要

Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris. Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion-(I/R-) induced myocardial injury and cardiac microcirculatory disturbance. The present study aimed to investigate the effect of CP at low dosage in a multiple dosing manner and to uncover the mechanism of antioxidative activity of CP. Male Sprague-Dawley rats were subjected to left anterior descending artery occlusion for 30 min followed by 60 min reperfusion. CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R. Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress. CP dramatically inhibited I/R-induced nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase subunit gp91(phox) expression and p67(phox) and p47(phox) translocation from cytosol to cell membrane. Translocation of cytosolic subunits to membrane is required for the activation of NADPH oxidase. These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation.

语种英语
WOS记录号WOS:000320850100001
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55698
Collection北京大学基础医学院_北大医学部天士力微循环研究中心
北京大学医学部管理机构_医学部
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Tradit Chinese & Western Med, Beijing 100191, Peoples R China
3.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med, Key Lab Stasis & Phlegm, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Yang, Xiao-Yuan,Zhao, Na,Liu, Yu-Ying,et al. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Yang, Xiao-Yuan.,Zhao, Na.,Liu, Yu-Ying.,Hu, Bai-He.,Sun, Kai.,...&Han, Jing-Yan.(2013).Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Yang, Xiao-Yuan,et al."Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
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