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学科主题: 基础医学
题名:
Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury
作者: Yang, Xiao-Yuan1,2; Zhao, Na1; Liu, Yu-Ying1; Hu, Bai-He1; Sun, Kai1; Chang, Xin1; Wei, Xiao-Hong1; Fan, Jing-Yu1; Han, Jing-Yan1,2,3,4
刊名: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
发表日期: 2013
DOI: 10.1155/2013/728020
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: MYOCARDIAL-INFARCTION ; ISCHEMIA-REPERFUSION ; SALVIA-MILTIORRHIZA ; NAD(P)H OXIDASE ; MICROCIRCULATORY DISTURBANCE ; INFLAMMATORY RESPONSE ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; BLOOD-PRESSURE ; VITAMIN-E
英文摘要:

Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris. Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion-(I/R-) induced myocardial injury and cardiac microcirculatory disturbance. The present study aimed to investigate the effect of CP at low dosage in a multiple dosing manner and to uncover the mechanism of antioxidative activity of CP. Male Sprague-Dawley rats were subjected to left anterior descending artery occlusion for 30 min followed by 60 min reperfusion. CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R. Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress. CP dramatically inhibited I/R-induced nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase subunit gp91(phox) expression and p67(phox) and p47(phox) translocation from cytosol to cell membrane. Translocation of cytosolic subunits to membrane is required for the activation of NADPH oxidase. These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation.

语种: 英语
所属项目编号: 2008ZX09401 ; 812736370
项目资助者: Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号: WOS:000320850100001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55698
Appears in Collections:基础医学院_北大医学部天士力微循环研究中心_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Tradit Chinese & Western Med, Beijing 100191, Peoples R China
3.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med, Key Lab Stasis & Phlegm, Beijing 100191, Peoples R China

Recommended Citation:
Yang, Xiao-Yuan,Zhao, Na,Liu, Yu-Ying,et al. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
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