学科主题基础医学
Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury
Yang, Xiao-Yuan1,2; Zhao, Na1; Liu, Yu-Ying1; Hu, Bai-He1; Sun, Kai1; Chang, Xin1; Wei, Xiao-Hong1; Fan, Jing-Yu1; Han, Jing-Yan1,2,3,4
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2013
DOI10.1155/2013/728020
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]MYOCARDIAL-INFARCTION ; ISCHEMIA-REPERFUSION ; SALVIA-MILTIORRHIZA ; NAD(P)H OXIDASE ; MICROCIRCULATORY DISTURBANCE ; INFLAMMATORY RESPONSE ; ENDOTHELIAL-CELLS ; OXIDATIVE STRESS ; BLOOD-PRESSURE ; VITAMIN-E
英文摘要

Cardiotonic pill (CP) is a compound Chinese medicine currently used in China for treatment of ischemic angina pectoris. Our previous results indicated that a single dosing of CP pretreatment at 0.8 g/kg attenuates ischemia/reperfusion-(I/R-) induced myocardial injury and cardiac microcirculatory disturbance. The present study aimed to investigate the effect of CP at low dosage in a multiple dosing manner and to uncover the mechanism of antioxidative activity of CP. Male Sprague-Dawley rats were subjected to left anterior descending artery occlusion for 30 min followed by 60 min reperfusion. CP was administrated daily by gavage for six days at 0.1, 0.4, and 0.8 g/kg/day before I/R. Results showed that multiple dosing of CP at three doses significantly reduced I/R-induced myocardial injury, microcirculatory disturbance, and oxidative stress. CP dramatically inhibited I/R-induced nicotinamide adenosine dinucleotide phosphate (NADPH) oxidase subunit gp91(phox) expression and p67(phox) and p47(phox) translocation from cytosol to cell membrane. Translocation of cytosolic subunits to membrane is required for the activation of NADPH oxidase. These data suggested that multiple dosing of CP at doses ranging from 0.1 to 0.8 g/kg/day reduced I/R-induced rat myocardial injury and microcirculatory disturbance, which was mediated by inhibition of NADPH oxidase activation.

语种英语
所属项目编号2008ZX09401 ; 812736370
资助者Ministry of Science and Technology of China ; National Natural Science Foundation of China ; Ministry of Science and Technology of China ; National Natural Science Foundation of China
WOS记录号WOS:000320850100001
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55698
专题基础医学院_北大医学部天士力微循环研究中心
作者单位1.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Integrat Tradit Chinese & Western Med, Beijing 100191, Peoples R China
3.State Adm Tradit Chinese Med, Key Lab Microcirculat, Beijing 100191, Peoples R China
4.State Adm Tradit Chinese Med, Key Lab Stasis & Phlegm, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Yang, Xiao-Yuan,Zhao, Na,Liu, Yu-Ying,et al. Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2013.
APA Yang, Xiao-Yuan.,Zhao, Na.,Liu, Yu-Ying.,Hu, Bai-He.,Sun, Kai.,...&Han, Jing-Yan.(2013).Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE.
MLA Yang, Xiao-Yuan,et al."Inhibition of NADPH Oxidase Mediates Protective Effect of Cardiotonic Pills against Rat Heart Ischemia/Reperfusion Injury".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE (2013).
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
728020.pdf(7815KB)期刊论文作者接受稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Xiao-Yuan]的文章
[Zhao, Na]的文章
[Liu, Yu-Ying]的文章
百度学术
百度学术中相似的文章
[Yang, Xiao-Yuan]的文章
[Zhao, Na]的文章
[Liu, Yu-Ying]的文章
必应学术
必应学术中相似的文章
[Yang, Xiao-Yuan]的文章
[Zhao, Na]的文章
[Liu, Yu-Ying]的文章
相关权益政策
暂无数据
收藏/分享
文件名: 728020.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。