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学科主题临床医学
Subcellular localization of basic Kruppel-like factor
Ma, XY; Wang, MJ; Qu, XH; Xing, GC; Zhu, YP; He, FC
关键词Bklf Subcellular Localization Nls
刊名ACTA BIOCHIMICA ET BIOPHYSICA SINICA
2003-03-01
35期:3页:255-260
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]RNA-POLYMERASE-II ; NUCLEAR-LOCALIZATION ; TRANSCRIPTION FACTORS ; ZINC-FINGER ; SIGNALS NLS ; DNA-BINDING ; DOMAINS ; PROTEIN ; SITES
英文摘要

To understand the function of basic Kruppel-like factor ( BKLF), it was confirmed by direct fluorescence and indirect fluorescence observation that hBKLF was localized in nucleus, and distributed throughout nucleoplasm in a speckled pattern, except the nucleoli. This pattern is similar to many but not all transcriptional factors. To clarify the specific sequence responsible for its nuclear localization, a series of deletion mutants of GFP/hBKLF were constructed. By observing their subcellular localization, it was found that the three. zinc fingers of hBKLF and the N-terminus aside from the fingers all served, as nuclear localization signals (NLS); the sub-NLS of hBKLF was located in the N-terminus, including the CtBP-binding motif and the proline rich domain. These results provide a basis for further clarifying the function of BKLF.

语种中文
WOS记录号WOS:000181873400007
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55699
专题北京大学第一临床医学院_血液内科
作者单位1.Beijing Inst Radiat Med, Beijing 100850, Peoples R China
2.Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
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GB/T 7714
Ma, XY,Wang, MJ,Qu, XH,et al. Subcellular localization of basic Kruppel-like factor[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2003,35(3):255-260.
APA Ma, XY,Wang, MJ,Qu, XH,Xing, GC,Zhu, YP,&He, FC.(2003).Subcellular localization of basic Kruppel-like factor.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,35(3),255-260.
MLA Ma, XY,et al."Subcellular localization of basic Kruppel-like factor".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 35.3(2003):255-260.
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