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学科主题: 药物依赖
题名:
Effects of Jitai Tablet, a Traditional Chinese Medicine, on Plasma Adrenocorticotropic Hormone and Cortisol Levels in Heroin Addicts During Abstinence
作者: Fan, Hua-ying1; Sun, Li1; Li, Xiao-xiao1; Zhou, Shao-bo2; Liang, Jun-cheng1; Yan, Ben-yong1; Li, Yu3; Deng, Yan-ping1
刊名: JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE
发表日期: 2014-07-01
DOI: 10.1089/acm.2012.0804
卷: 20, 期:7, 页:527-534
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
关键词[WOS]: PITUITARY-ADRENAL RESPONSE ; HYPOTHALAMIC NORADRENERGIC ACTIVITY ; CORTICOTROPIN-RELEASING-FACTOR ; DISCRETE BRAIN-REGIONS ; BETA-ENDORPHIN ; MORPHINE-WITHDRAWAL ; DEPENDENT PATIENTS ; OPIOID DEPENDENCE ; AXIS ; NALOXONE
英文摘要:

Objectives: To investigate the changes in adrenocorticotropic hormone (ACTH) and cortisol in heroin addicts given Jitai tablet treatment during abstinence.

Design: Double-blind, randomized, placebo-controlled clinical trial.

Settings/Location: Drug Rehabilitation Bureau of Shanghai Police, China.

Participants: 99 volunteers, including 69 heroin addicts and 30 healthy volunteers.

Interventions: 69 heroin addicts randomly divided into two groups: the Jitai tablet group, which comprised 34 heroin addicts given Jitai tablet treatment during abstinence, and the placebo group, which comprised 35 heroin addicts given placebo. A control group consisted of 30 sex-and age-matched healthy volunteers.

Outcome Measures: ACTH and cortisol in plasma were measured in all groups at baseline and in the Jitai tablet and placebo groups on the third, seventh, and 14th days of abstinence.

Results: Levels of both ACTH (p<.01) and cortisol (p<.001) were significantly higher in heroin addicts at baseline than in the healthy volunteers. Jitai tablet treatment restored plasma cortisol levels to normal more rapidly than did placebo treatment (p<.05), but not ACTH levels. A positive correlation between ACTH and cortisol values at baseline (p<.01) was also found with withdrawal symptom scores and daily dosages of heroin.

Conclusions: Heroin addicts could respond to Jitai tablets through changes in the hypothalamus-pituitary-adrenal axis.

语种: 英语
所属项目编号: 2008BAI49B01 ; 2009CB522000
项目资助者: National Science and Technology Support Program of China ; National Basic Research Program of China
WOS记录号: WOS:000339201600002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55700
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Drug Rehabil Bur Shanghai Police, Shanghai, Peoples R China
2.Peking Univ, Dept Clin Pharmacol, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
3.Univ Bedfordshire, Inst Biomed & Environm Sci & Technol, Luton, Beds, England

Recommended Citation:
Fan, Hua-ying,Sun, Li,Li, Xiao-xiao,et al. Effects of Jitai Tablet, a Traditional Chinese Medicine, on Plasma Adrenocorticotropic Hormone and Cortisol Levels in Heroin Addicts During Abstinence[J]. JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE,2014,20(7):527-534.
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