IR@PKUHSC  > 北京大学第二临床医学院  > 血液科
学科主题临床医学
Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key
Fu, Haixia; Xu, Lanping; Liu, Daihong; Zhang, Xiaohui; Liu, Kaiyan; Chen, Huan; Wang, Yu; Han, Wei; Han, Tingting; Huang, Xiaojun
关键词Allogeneic Hematopoietic Stem Cell Transplantation Haploidentical Atg Late-onset Hemorrhagic Cystitis Risk Factor
刊名INTERNATIONAL JOURNAL OF HEMATOLOGY
2013-07-01
DOI10.1007/s12185-013-1350-8
98期:1页:89-95
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]BONE-MARROW-TRANSPLANTATION ; VERSUS-HOST-DISEASE ; DONOR LYMPHOCYTE INFUSION ; ANTITHYMOCYTE GLOBULIN ; IMMUNE RECONSTITUTION ; BK VIRUS ; HEMATOLOGICAL MALIGNANCIES ; CONDITIONING REGIMEN ; CMV REACTIVATION ; RISK-FACTORS
英文摘要

Late-onset hemorrhagic cystitis (LOHC) is a common complication following allogeneic hematopoietic stem cell transplantation (HSCT), but its cause remains obscure. More attention to risk factors for LOHC is needed. We retrospectively analyzed patients with advanced leukemia who had been treated with ATG-containing conditioning regimens to evaluate the influence of different doses of ATG on LOHC after haploidentical HSCT. Seventy-five patients undergoing haploidentical HSCT from January 2003 to February 2011 were evaluated. A total of 39 patients receiving transplantation before June 2008 were treated with high-dose ATG (10 mg/kg), whereas 36 patients received low-dose ATG (6 mg/kg) thereafter. LOHC occurred in 16.7 % of the patients with low-dose ATG, and in 38.5 % of the patients with high-dose ATG (P = 0.027). Univariate analysis showed high-dose ATG, male gender and cytomegalovirus reactivation to be significant risk factors for LOHC. However, only high-dose ATG (HR 2.96, 95 % CI 1.143-7.663, P = 0.025) and male gender (HR 4.033, 95 % CI 1.355-12.008, P = 0.012) were independent risk factors, as shown by multivariate analysis. In the setting of haploidentical HSCT, we concluded that LOHC is more prevalent in recipients of high-dose ATG and male patients. Future studies should focus on immune reconstitution and virus infection after haploidentical HSCT with 6 mg/kg or 10 mg/kg ATG.

语种英语
WOS记录号WOS:000321769400013
项目编号30725038 ; Z111107067311070
资助机构National Natural Science Foundation of China ; Beijing Municipal Science and Technology Program
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55703
专题北京大学第二临床医学院_血液科
医学人文研究院/公共教学部_哲学与社会科学系
作者单位Peking Univ, Peoples Hosp, Inst Hematol, Beijing Key Lab Hematopoiet Stem Cell Transplanta, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Fu, Haixia,Xu, Lanping,Liu, Daihong,et al. Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key[J]. INTERNATIONAL JOURNAL OF HEMATOLOGY,2013,98(1):89-95.
APA Fu, Haixia.,Xu, Lanping.,Liu, Daihong.,Zhang, Xiaohui.,Liu, Kaiyan.,...&Huang, Xiaojun.(2013).Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key.INTERNATIONAL JOURNAL OF HEMATOLOGY,98(1),89-95.
MLA Fu, Haixia,et al."Late-onset hemorrhagic cystitis after haploidentical hematopoietic stem cell transplantation in patients with advanced leukemia: differences in ATG dosage are key".INTERNATIONAL JOURNAL OF HEMATOLOGY 98.1(2013):89-95.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Fu, Haixia]的文章
[Xu, Lanping]的文章
[Liu, Daihong]的文章
百度学术
百度学术中相似的文章
[Fu, Haixia]的文章
[Xu, Lanping]的文章
[Liu, Daihong]的文章
必应学术
必应学术中相似的文章
[Fu, Haixia]的文章
[Xu, Lanping]的文章
[Liu, Daihong]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。