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学科主题: 口腔医学
题名:
MMP-Inhibitory Effect of Chlorhexidine Applied in a Self-etching Adhesive
作者: Zhou, Jianfeng1,2,3; Tan, Jianguo1,2,3; Yang, Xu1,2,3; Xu, Xuemei6; Li, Deli4,5; Chen, Li1,2,3
关键词: chlorhexidine ; matrix metalloproteinases ; self-etching adhesives ; bond degradation ; collagenolytic activity
刊名: JOURNAL OF ADHESIVE DENTISTRY
发表日期: 2011-04-01
DOI: 10.3290/j.jad.a18783
卷: 13, 期:2, 页:111-115
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: RESIN-DENTIN BONDS ; WATER STORAGE ; IN-VIVO ; MATRIX METALLOPROTEINASES ; HYBRID LAYER ; DEGRADATION ; ACTIVATION ; STRENGTH ; VITRO ; DURABILITY
英文摘要:

Purpose: To evaluate the MMP-inhibitory effect of chlorhexidine when incorporated in the primer of a two-step self-etching adhesive (Clearfil SE Bond).

Materials and Methods: Powdered dentin made from human teeth was treated with Clearfil SE Bond primers containing chlorhexidine of different concentrations for 20 s or for 2 min. The collagenolytic activity of the dentin powder was assayed using fluorescein-labelled collagen.

Results: Untreated dentin powder contains a low but measurable level of intrinsic activity, which was significantly inhibited by 0.05% chlorhexidine. Treating dentin powder for 20 s with SE Bond primers containing chlorhexidine (0.5%, 1.0%, and 2.0%) reduced the collagenolytic activities by 15.6%, 44.9%, and 56.7% respectively. When treated for 2 min, only SE Bond primer containing 2.0% chlorhexidine could inhibit the collagenolytic activity by 41.1%.

Conclusion: When incorporated in a two-step self-etching adhesive primer (Clearfil SE Bond primer), chlorhexidine can partially maintain its inhibitory effect on MMPs.

语种: 英语
WOS记录号: WOS:000289754300002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55708
Appears in Collections:北京大学口腔医学院_口腔修复科_期刊论文

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作者单位: 1.Peking Univ, Sch Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
3.Peking Univ, Hosp Stomatol, Dept Prosthodont, Beijing 100081, Peoples R China
4.Peking Univ, Sch Stomatol, Dept Gen Dent, Dent Ctr 2, Beijing 100081, Peoples R China
5.Peking Univ, Hosp Stomatol, Dept Gen Dent, Dent Ctr 2, Beijing 100081, Peoples R China
6.Chinese Acad Med Sci, Inst Basic Med Sci, Peking Union Med Coll, Beijing 100730, Peoples R China

Recommended Citation:
Zhou, Jianfeng,Tan, Jianguo,Yang, Xu,et al. MMP-Inhibitory Effect of Chlorhexidine Applied in a Self-etching Adhesive[J]. JOURNAL OF ADHESIVE DENTISTRY,2011,13(2):111-115.
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