北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection
作者: Rao, Hui-Ying1; Ren, Fu-Rong2; Guan, Wen-Li1; Houde, Michel3; Du, Shao-Cai1; Liu, Chang-Li2; Gong, Xiao-Yan2; Wei, Lai1
关键词: Hepatitis C ; Anti-HCV ; Performance evaluation ; Sensitivity ; Specificity
刊名: JOURNAL OF VIROLOGICAL METHODS
发表日期: 2009-12-01
DOI: 10.1016/j.jviromet.2009.08.008
卷: 162, 期:1-2, 页:203-207
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]: Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Virology
关键词[WOS]: BLOOD-DONORS ; IMPACT ; PREVALENCE ; ANTIBODIES ; ASSAYS ; NAT
英文摘要:

The EIAgen HCV test (Adaltis Inc., Montreal, Canada) is an enzyme immunoassay (EIA) for the detection of anti-hepatitis C virus (HCV) antibodies. This study compared the performance of this test side-by-side with the current Ortho HCV 3.0 Anti-HCV assay (Ortho-Clinical Diagnostics Inc., Johnson & Johnson Company, Raritan, NY, USA). Among 2559 specimens examined, 178 were true positives, 2376 were true negatives and 5 were indeterminate. The sensitivity of the EIAgen HCV test was 100%, versus 98.3% for the Ortho HCV test, while their respective specificities were 98.1% and 98.2%. The EIAgen HCV test gave a positive predictive value of 79.8% and a negative predictive value of 100%. Overall, the concordance of this test with the Ortho HCV test was 98.2%. Specimens from potentially interfering substances, such as sera from pregnant women, sera from patients with acute non-C hepatitis, autoimmune diseases, lipidemia, or from patients undergoing hemolysis, showed no interference with either EIA. An EIAgen HCV test signal-to-cut-off ratio of > 5.9 would be highly predictive of a true-positive finding in these specimens. The EIAgen HCV test is well suited for screening blood and blood products in antibodies to HCV. (c) 2009 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2005CB522902 ; 2007CB512900 ; 2006AA02A410 ; 30571639 ; 2008ZX70002-012 ; 2008ZX10002-013
项目资助者: Chinese Basic Research Foundation 973 ; 863 program ; NSFC ; National Science and Technology Key Project during the 11th Five-Year Plan Period ; Key Clinical Research Program of Ministry of Health
WOS记录号: WOS:000271586500030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55714
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Adaltis Dev Inc, Laval, PQ, Canada
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China

Recommended Citation:
Rao, Hui-Ying,Ren, Fu-Rong,Guan, Wen-Li,et al. Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection[J]. JOURNAL OF VIROLOGICAL METHODS,2009,162(1-2):203-207.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Rao, Hui-Ying]'s Articles
[Ren, Fu-Rong]'s Articles
[Guan, Wen-Li]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Rao, Hui-Ying]‘s Articles
[Ren, Fu-Rong]‘s Articles
[Guan, Wen-Li]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace