学科主题临床医学
Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection
Rao, Hui-Ying1; Ren, Fu-Rong2; Guan, Wen-Li1; Houde, Michel3; Du, Shao-Cai1; Liu, Chang-Li2; Gong, Xiao-Yan2; Wei, Lai1
关键词Hepatitis c Anti-hcv Performance Evaluation Sensitivity Specificity
刊名JOURNAL OF VIROLOGICAL METHODS
2009-12-01
DOI10.1016/j.jviromet.2009.08.008
162期:1-2页:203-207
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Biotechnology & Applied Microbiology ; Virology
研究领域[WOS]Biochemistry & Molecular Biology ; Biotechnology & Applied Microbiology ; Virology
关键词[WOS]BLOOD-DONORS ; IMPACT ; PREVALENCE ; ANTIBODIES ; ASSAYS ; NAT
英文摘要

The EIAgen HCV test (Adaltis Inc., Montreal, Canada) is an enzyme immunoassay (EIA) for the detection of anti-hepatitis C virus (HCV) antibodies. This study compared the performance of this test side-by-side with the current Ortho HCV 3.0 Anti-HCV assay (Ortho-Clinical Diagnostics Inc., Johnson & Johnson Company, Raritan, NY, USA). Among 2559 specimens examined, 178 were true positives, 2376 were true negatives and 5 were indeterminate. The sensitivity of the EIAgen HCV test was 100%, versus 98.3% for the Ortho HCV test, while their respective specificities were 98.1% and 98.2%. The EIAgen HCV test gave a positive predictive value of 79.8% and a negative predictive value of 100%. Overall, the concordance of this test with the Ortho HCV test was 98.2%. Specimens from potentially interfering substances, such as sera from pregnant women, sera from patients with acute non-C hepatitis, autoimmune diseases, lipidemia, or from patients undergoing hemolysis, showed no interference with either EIA. An EIAgen HCV test signal-to-cut-off ratio of > 5.9 would be highly predictive of a true-positive finding in these specimens. The EIAgen HCV test is well suited for screening blood and blood products in antibodies to HCV. (c) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000271586500030
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55714
专题北京大学第二临床医学院_北京大学肝病研究所
作者单位1.Beijing Red Cross Blood Ctr, Beijing, Peoples R China
2.Adaltis Dev Inc, Laval, PQ, Canada
3.Peking Univ, Peoples Hosp, Inst Hepatol, Beijing 100044, Peoples R China
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GB/T 7714
Rao, Hui-Ying,Ren, Fu-Rong,Guan, Wen-Li,et al. Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection[J]. JOURNAL OF VIROLOGICAL METHODS,2009,162(1-2):203-207.
APA Rao, Hui-Ying.,Ren, Fu-Rong.,Guan, Wen-Li.,Houde, Michel.,Du, Shao-Cai.,...&Wei, Lai.(2009).Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection.JOURNAL OF VIROLOGICAL METHODS,162(1-2),203-207.
MLA Rao, Hui-Ying,et al."Evaluation of the performance of the EIAgen HCV test for detection of hepatitis C virus infection".JOURNAL OF VIROLOGICAL METHODS 162.1-2(2009):203-207.
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