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学科主题: 公共卫生
题名:
Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status
作者: Zhou, Cheng-Jiang1; Zhang, Liu-Wei2; Gao, Fang1; Zhang, Bin1; Wang, Ying1; Chen, Da-Fang2; Jia, Yan-Bin1
关键词: H. pylori ; MUC5AC ; tagSNPs ; seroprevalence
刊名: ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
发表日期: 2014
DOI: 10.7314/APJCP.2014.15.24.10719
卷: 15, 期:24, 页:10719-10722
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: GASTRIC-CANCER ; INFECTION ; RISK ; ASSOCIATION ; POPULATION ; EXPRESSION ; STOMACH
英文摘要:

Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.

语种: 英语
所属项目编号: 30960169 ; 81250024 ; 20110501 ; 2008-34
项目资助者: National Natural Science Foundation of China ; Inner Mongolian Committee of Science and Technology, China ; Foundation of Medicine and Health of Baotou, China
WOS记录号: WOS:000351058900026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55715
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Baotou Med Coll, Sch Basic Med, Baotou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,et al. Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(24):10719-10722.
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