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Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status
Zhou, Cheng-Jiang1; Zhang, Liu-Wei2; Gao, Fang1; Zhang, Bin1; Wang, Ying1; Chen, Da-Fang2; Jia, Yan-Bin1
关键词H. Pylori Muc5ac Tagsnps Seroprevalence
刊名ASIAN PACIFIC JOURNAL OF CANCER PREVENTION
2014
DOI10.7314/APJCP.2014.15.24.10719
15期:24页:10719-10722
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
资助者National Natural Science Foundation of China ; Inner Mongolian Committee of Science and Technology, China ; Foundation of Medicine and Health of Baotou, China ; National Natural Science Foundation of China ; Inner Mongolian Committee of Science and Technology, China ; Foundation of Medicine and Health of Baotou, China
研究领域[WOS]Oncology
关键词[WOS]GASTRIC-CANCER ; INFECTION ; RISK ; ASSOCIATION ; POPULATION ; EXPRESSION ; STOMACH
英文摘要

Several lines of evidence suggest that MUC5AC genetic polymorphisms might confer susceptibility to H. pylori infection and therefore gastric cancer risk. We here assessed the association of common polymorphisms in the MUC5AC gene with H. pylori seroprevalence using an LD-based tagSNP approach in a north-western Chinese Han population. A total of 12 tagSNPs were successfully genotyped among 281 unrelated ethnic Han Chinese who had no cancer history, and no identifiable gastric disease or genetic disease. No significant association between any alleles, genotypes or haplotypes and H. pylori seroprevalence was observed. Our results suggest that common genetic variations in MUC5AC gene might not make a major contribution to the risk of H. pylori infection.

语种英语
所属项目编号30960169 ; 81250024 ; 20110501 ; 2008-34
资助者National Natural Science Foundation of China ; Inner Mongolian Committee of Science and Technology, China ; Foundation of Medicine and Health of Baotou, China ; National Natural Science Foundation of China ; Inner Mongolian Committee of Science and Technology, China ; Foundation of Medicine and Health of Baotou, China
WOS记录号WOS:000351058900026
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55715
专题北京大学公共卫生学院
作者单位1.Baotou Med Coll, Sch Basic Med, Baotou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
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GB/T 7714
Zhou, Cheng-Jiang,Zhang, Liu-Wei,Gao, Fang,et al. Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status[J]. ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,2014,15(24):10719-10722.
APA Zhou, Cheng-Jiang.,Zhang, Liu-Wei.,Gao, Fang.,Zhang, Bin.,Wang, Ying.,...&Jia, Yan-Bin.(2014).Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status.ASIAN PACIFIC JOURNAL OF CANCER PREVENTION,15(24),10719-10722.
MLA Zhou, Cheng-Jiang,et al."Common Genetic Variations in the MUC5AC Gene are Not Related to Helicobacter pylori Serologic Status".ASIAN PACIFIC JOURNAL OF CANCER PREVENTION 15.24(2014):10719-10722.
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