北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学深圳医院  > 期刊论文
学科主题: 临床医学
题名:
Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study
作者: Yang, Hong Y.1; Chu, Mei1; Zheng, Li W.2,3; Zwahlen, Roger A.2,3; Luo, Juan1; Zou, Duo H.1; Sun, Shun T.1
刊名: ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
发表日期: 2008-11-01
DOI: 10.1016/j.tripleo.2008.08.012
卷: 106, 期:5, 页:721-728
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Dentistry, Oral Surgery & Medicine
关键词[WOS]: IMMUNOTHERAPY ; ACTIVATION ; CARCINOMA ; MODEL
英文摘要:

Objective. Tumors may present antigens to T cells but lack costimulatory signals which are necessary to initialize an effective immunologic response. This study aimed to develop a tumor cell-based cancer vaccine by genetically modifying oral squamous cell cancer (OSCC) cell line Tca8113 with human B7-H3 immunoglobulin, and to evaluate its efficacy in enhancing the tumor-specific immune response.

Study design. Human B7-H3 gene was extracted from isolated T lymphocytes of healthy volunteers. Tumor cell vaccine TCV-hB7-H3 and mock control were prepared by transfecting Tca8113 cells with B7-H3 or mock vector. After being stimulated with TCV-hB7-H3 or mock control, the proliferation, IFN-mu expression, and cytotoxicity of the T cells were assessed.

Results. The Tca8113 cells transfected with human B7-H3 significantly enhanced the proliferation, IFN-mu expression, and cytotoxicity of the T cells.

Conclusions. Genetically modified OSCC cells encoding B7-H3 enhance the induction of tumor specific immune response. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 721-8)

语种: 英语
所属项目编号: 30672335 ; 06027977 ; 200601008
项目资助者: National Nature Science Foundation ; Guangdong Provincial Nature Science Foundation ; Shenzhen Science and Technology Program
WOS记录号: WOS:000259973000019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55716
Appears in Collections:北京大学深圳医院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Dept Oral & Maxillofacial Surg, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Univ Hong Kong, Dept Oral & Maxillofacial Surg, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China

Recommended Citation:
Yang, Hong Y.,Chu, Mei,Zheng, Li W.,et al. Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY,2008,106(5):721-728.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yang, Hong Y.]'s Articles
[Chu, Mei]'s Articles
[Zheng, Li W.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yang, Hong Y.]‘s Articles
[Chu, Mei]‘s Articles
[Zheng, Li W.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace