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Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study
Yang, Hong Y.1; Chu, Mei1; Zheng, Li W.2,3; Zwahlen, Roger A.2,3; Luo, Juan1; Zou, Duo H.1; Sun, Shun T.1
刊名ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY
2008-11-01
DOI10.1016/j.tripleo.2008.08.012
106期:5页:721-728
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Dentistry, Oral Surgery & Medicine
研究领域[WOS]Dentistry, Oral Surgery & Medicine
关键词[WOS]IMMUNOTHERAPY ; ACTIVATION ; CARCINOMA ; MODEL
英文摘要

Objective. Tumors may present antigens to T cells but lack costimulatory signals which are necessary to initialize an effective immunologic response. This study aimed to develop a tumor cell-based cancer vaccine by genetically modifying oral squamous cell cancer (OSCC) cell line Tca8113 with human B7-H3 immunoglobulin, and to evaluate its efficacy in enhancing the tumor-specific immune response.

Study design. Human B7-H3 gene was extracted from isolated T lymphocytes of healthy volunteers. Tumor cell vaccine TCV-hB7-H3 and mock control were prepared by transfecting Tca8113 cells with B7-H3 or mock vector. After being stimulated with TCV-hB7-H3 or mock control, the proliferation, IFN-mu expression, and cytotoxicity of the T cells were assessed.

Results. The Tca8113 cells transfected with human B7-H3 significantly enhanced the proliferation, IFN-mu expression, and cytotoxicity of the T cells.

Conclusions. Genetically modified OSCC cells encoding B7-H3 enhance the induction of tumor specific immune response. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008; 106: 721-8)

语种英语
WOS记录号WOS:000259973000019
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55716
专题北京大学深圳医院
北京大学口腔医学院_外科
作者单位1.Peking Univ, Dept Oral & Maxillofacial Surg, Shenzhen Hosp, Shenzhen 518036, Peoples R China
2.Univ Hong Kong, Dept Oral & Maxillofacial Surg, Prince Philip Dent Hosp, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Hong Kong, Hong Kong, Peoples R China
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GB/T 7714
Yang, Hong Y.,Chu, Mei,Zheng, Li W.,et al. Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study[J]. ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY,2008,106(5):721-728.
APA Yang, Hong Y..,Chu, Mei.,Zheng, Li W..,Zwahlen, Roger A..,Luo, Juan.,...&Sun, Shun T..(2008).Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study.ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY,106(5),721-728.
MLA Yang, Hong Y.,et al."Transgenic B7-H3 therapy induces tumor-specific immune response in human oral squamous cell cancer: an in vitro study".ORAL SURGERY ORAL MEDICINE ORAL PATHOLOGY ORAL RADIOLOGY AND ENDODONTOLOGY 106.5(2008):721-728.
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