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学科主题: 临床医学
题名:
MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults
作者: Qin, Xianhui1; Li, Jianping2,3; Cui, Yimin4; Liu, Zeyuan5; Zhao, Zhigang6; Ge, Junbo7; Guan, Deming8; Hu, Jian9; Wang, Yanni10; Zhang, Fumin11; Xu, Xin12; Wang, Xiaobin13,14; Xu, Xiping1; Huo, Yong2,3
关键词: Folic acid supplementation ; MTHFR C677T polymorphism ; MTR A2756G polymorphism ; Homocysteine-lowering efficacy
刊名: NUTRITION JOURNAL
发表日期: 2012-01-10
DOI: 10.1186/1475-2891-11-2
卷: 11
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nutrition & Dietetics
研究领域[WOS]: Nutrition & Dietetics
关键词[WOS]: NEURAL-TUBE DEFECTS ; METHYLENETETRAHYDROFOLATE REDUCTASE ; CARDIOVASCULAR-DISEASE ; DOUBLE-BLIND ; CONTROLLED-TRIAL ; VITAMIN THERAPY ; BLOOD-PRESSURE ; RISK-FACTORS ; SUPPLEMENTATION ; FOLATE
英文摘要:

Background: This study aimed to investigate if the homocysteine-lowering efficacy of two commonly used physiological doses (0.4 mg/d and 0.8 mg/d) of folic acid (FA) can be modified by individual methylenetetrahydrofolate reductase (MTHFR) C677T and/or methionine synthase (MTR) A2756G polymorphisms in hypertensive Chinese adults.

Methods: A total of 480 subjects with mild or moderate essential hypertension were randomly assigned to three treatment groups: 1) enalapril only (10 mg, control group); 2) enalapril-FA tablet [10: 0.4 mg (10 mg enalapril combined with 0.4 mg of FA), low FA group]; and 3) enalapril-FA tablet (10: 0.8 mg, high FA group), once daily for 8 weeks.

Results: After 4 or 8 weeks of treatment, homocysteine concentrations were reduced across all genotypes and FA dosage groups, except in subjects with MTR 2756AG/GG genotype in the low FA group at week 4. However, compared to subjects with MTHFR 677CC genotype, homocysteine concentrations remained higher in subjects with CT or TT genotype in the low FA group (P < 0.05 for either of these genotypes) and TT genotype in the high FA group (P < 0.05). Furthermore, subjects with TT genotype showed a greater homocysteine-lowering response than did subjects with CC genotype in the high FA group (mean percent reduction of homocysteine at week 8: CC 10.8% vs. TT: 22.0%, P = 0.005), but not in the low FA group (CC 9.9% vs. TT 11.2%, P = 0.989).

Conclusions: This study demonstrated that MTHFR C677T polymorphism can not only affect homocysteine concentration at baseline and post-FA treatment, but also can modify therapeutic responses to various dosages of FA supplementation.

语种: 英语
所属项目编号: 2002kj174ZC
项目资助者: Beijing Huaanfo Biomedical Research Center Inc., Beijing, China ; Anhui Provincial Ministry of Education, Anhui Provincial Ministry of Science and Technology, Anhui Medical University Biomedical Institute
WOS记录号: WOS:000300369600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55718
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Inst Biomed, Hefei, Peoples R China
2.Peking Univ, Hosp 1, Ctr Heart, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Pharm, Beijing 100871, Peoples R China
4.Peking Univ, Hosp 1, Dept Cardiol, Beijing 100871, Peoples R China
5.Mil Med Acad, Affiliated Hosp 1, Dept Pharm, Beijing, Peoples R China
6.Capital Med Univ, Beijing Tiantan Hosp, Dept Pharm, Beijing, Peoples R China
7.Fudan Univ, Zhongshan Hosp, Dept Cardiol, Shanghai 200433, Peoples R China
8.Harbin Med Univ, Clin Med Coll 1, Dept Cardiol, Harbin, Peoples R China
9.China Med Univ, Affiliated Hosp 1, Dept Cardiol, Shenyang, Peoples R China
10.Xi An Jiao Tong Univ, Sch Med, Affiliated Hosp 1, Dept Cardiol, Xian 710049, Peoples R China
11.Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing, Jiangsu, Peoples R China
12.So Med Univ, Guangdong Inst Nephrol, Guangzhou, Guangdong, Peoples R China
13.Northwestern Univ, Childrens Mem Hosp, Feinberg Sch Med, Mary Ann & J Milburn Smith Child Hlth Res Program, Chicago, IL 60614 USA
14.Northwestern Univ, Dept Pediat, Feinberg Sch Med, Childrens Mem Res Ctr, Chicago, IL 60611 USA

Recommended Citation:
Qin, Xianhui,Li, Jianping,Cui, Yimin,et al. MTHFR C677T and MTR A2756G polymorphisms and the homocysteine lowering efficacy of different doses of folic acid in hypertensive Chinese adults[J]. NUTRITION JOURNAL,2012,11.
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