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学科主题基础医学
Cardiovascular effects of urotensin II in different brain areas
Lu, Y; Zou, CJ; Huang, DW; Tang, CS
关键词urotensin II A(1) area A(2) area paraventricular nucleus arcuate nucleus
刊名PEPTIDES
2002-09-01
23期:9页:1631-1635
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
研究领域[WOS]Biochemistry & Molecular Biology ; Pharmacology & Pharmacy
关键词[WOS]ACETYLCHOLINESTERASE-CONTAINING NEURONS ; CENTRAL-NERVOUS-SYSTEM ; TOPOGRAPHIC ATLAS ; RAT-BRAIN ; CATECHOLAMINE ; NUCLEUS ; FROG
英文摘要

It has been shown that intracerebroventricular injection of urotensin II (UII)-induced hypotensive and bradycardiac responses. Here, we tested the cardiovascular roles of UII in different brain areas by microinjection of UII into the A(1) and A(2) areas (noradrenergic cells found in the lower part of the medulla that have been designated either A(1) or A(2) areas), the paraventricular and the arcuate nucleus. In urethane-anaesthetized rats, we observed that: (1) microinjection of UII into the A, area induced dose-related depressor and bradycardiac responses; (2) mean arterial blood pressure (mABP) and heart rate (HR) did not change significantly after microinjection of UII into the A(2) area; and (3) significant increases in mABP and HR were induced after microinjection of 10 pmol UII into either the paraventricular or arcuate nucleus. The above results suggest that UII, in different brain areas, plays different roles in cardiovascular regulation and the A, area is a very important action site for UII in cardiovascular regulation. (C) 2002 Elsevier Science Inc. All rights reserved.

语种英语
WOS记录号WOS:000178339300013
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被引频次:45[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55719
专题基础医学院_生理学与病理生理学系
作者单位Peking Univ, Dept Physiol, Hlth Sci Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Lu, Y,Zou, CJ,Huang, DW,et al. Cardiovascular effects of urotensin II in different brain areas[J]. PEPTIDES,2002,23(9):1631-1635.
APA Lu, Y,Zou, CJ,Huang, DW,&Tang, CS.(2002).Cardiovascular effects of urotensin II in different brain areas.PEPTIDES,23(9),1631-1635.
MLA Lu, Y,et al."Cardiovascular effects of urotensin II in different brain areas".PEPTIDES 23.9(2002):1631-1635.
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