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Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice
Mu, Xin1,2; He, Guo-Rong1,2; Yuan, Xia3; Li, Xiao-Xiu1,2; Du, Guan-Hua1,2
关键词Parkinson&Prime 1-methyl-4-phenyl-12 s Disease 3 Baicalein 6-tetrahydropyridine Antioxidant
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2011-04-01
DOI10.1016/j.pbb.2011.01.011
98期:2页:286-291
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]PARKINSONS-DISEASE ; ANIMAL-MODELS ; NEUROTOXICITY
英文摘要

Many studies of Parkinson′s disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson′s disease. (C) 2011 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000289396300018
项目编号200802041 ; 2009ZM09501-021
资助机构Research Special Fund for Public Welfare Industry of Health ; National Significant Projects of New Drugs Creation
引用统计
被引频次:44[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55722
专题北京大学药学院
北京大学药学院_分子与细胞药理学系
作者单位1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
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GB/T 7714
Mu, Xin,He, Guo-Rong,Yuan, Xia,et al. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,98(2):286-291.
APA Mu, Xin,He, Guo-Rong,Yuan, Xia,Li, Xiao-Xiu,&Du, Guan-Hua.(2011).Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,98(2),286-291.
MLA Mu, Xin,et al."Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 98.2(2011):286-291.
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