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学科主题: 药学
题名:
Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice
作者: Mu, Xin1,2; He, Guo-Rong1,2; Yuan, Xia3; Li, Xiao-Xiu1,2; Du, Guan-Hua1,2
关键词: 1-Methyl-4-phenyl-12,3,6-tetrahydropyridine ; Parkinson&prime ; s disease ; Baicalein ; Antioxidant
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2011-04-01
DOI: 10.1016/j.pbb.2011.01.011
卷: 98, 期:2, 页:286-291
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: PARKINSONS-DISEASE ; ANIMAL-MODELS ; NEUROTOXICITY
英文摘要:

Many studies of Parkinson′s disease suggest that oxidative stress is involved in the neurodegenerative process. Baicalein has been shown to have antioxidant effects. The present study examines the effect of baicalein on 1-methyl-4-phenyl-1,2,3.6-tetrahydropyridine (MPTP)-induced neurotoxicity in C57BL/6 mice. MPTP treatment impaired spontaneous motor activity and rotarod performance, but baicalein improved this deficit. Moreover, baicalein at 280 and 560 mg/kg exhibited a protective effect against the MPTP-induced decrease in tyrosine hydroxylase (TH)-positive fibers in the substantia nigra, demonstrated by the immunohistological, morphological and behavioral outcomes. MPTP treatment also decreased dopamine levels in the striatum. However, treatment with baicalein attenuated these decreases in dopamine levels by changing dopamine catabolism and inhibiting dopamine turnover. The neuroprotective effect of baicalein on dopaminergic neurons may partly be due to its antioxidant properties. Therefore, we speculate that baicalein might be a promising candidate for prevention or treatment of oxidative stress-related neurodegenerative disorders such as Parkinson′s disease. (C) 2011 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 200802041 ; 2009ZM09501-021
项目资助者: Research Special Fund for Public Welfare Industry of Health ; National Significant Projects of New Drugs Creation
WOS记录号: WOS:000289396300018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55722
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China
2.Peking Union Med Coll, Beijing 100050, Peoples R China
3.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Mu, Xin,He, Guo-Rong,Yuan, Xia,et al. Baicalein protects the brain against neuron impairments induced by MPTP in C57BL/6 mice[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2011,98(2):286-291.
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