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学科主题: 临床医学
题名:
In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China
作者: Chen, Hongbin; Wang, Zhanwei; Li, Henan; Wang, Qi; Zhao, Chunjiang; He, Wenqiang; Wang, Xiaojuan; Zhang, Feifei; Wang, Hui
刊名: JAPANESE JOURNAL OF INFECTIOUS DISEASES
发表日期: 2015-07-01
DOI: 10.7883/yoken.JJID.2014.202
卷: 68, 期:4, 页:263-267
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: URINARY-TRACT-INFECTIONS ; PSEUDOMONAS-AERUGINOSA ; LACTAMASE INHIBITOR ; ESCHERICHIA-COLI ; BIAPENEM ; RESISTANCE ; ENTEROBACTERIACEAE ; AMINOGLYCOSIDE ; ACID
英文摘要:

To evaluate the in vitro antimicrobial activities of biapenem, arbekacin, and cefminox against different gram-negative bacterial isolates in China, a total of 100 non-duplicated Escherichia coli, 100 Acinetobacter baumannii, 100 Pseudomonas aeruginosa, and 99 Klebsiella pneumoniae isolates were collected from 6 teaching hospitals in China in 2012. The minimal inhibitory concentrations (MICs) of biapenem, arbekacin, cefminox and 13 other antibiotics were determined by the broth microdilution method. The carbapenems (biapenem, meropenem, and imipenem) exhibited high antimicrobial activity against E. coli (98%) and K. pneumoniae (>= 95%), followed by colistin and amikacin. The MIC50 and MIC90 of biapenem against E. coli were <= 0.06 mg/L and 0.25 mg/L, respectively. For K. pneumoniae, the MIC50, and MIC90 of biapenem were 0.25 mg/L and 1.0 mg/L, respectively. The MIC50 and MIC90 of cefminox against E. coli were 1.0 mg/L and 4.0 mg/L, respectively. The resistance rates of A. baumannii to most of the antibiotics were more than 50%, except for colistin. Amikacin was the most active antibiotic against P. aeruginosa (97%), followed by colistin (93%). The MIC50 and MIC90 of arbekacin against P. aeruginosa were 2.0 mg/L and 8.0 mg/L, respectively. In conclusion, carbapenems, colistin, amikacin, and arbekacin exhibited high antimicrobial activities against gram-negative bacteria, except A. baumannii.

语种: 英语
项目资助者: Meiji Seika Pharma Co., Ltd.
WOS记录号: WOS:000359038000001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55723
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China

Recommended Citation:
Chen, Hongbin,Wang, Zhanwei,Li, Henan,et al. In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China[J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES,2015,68(4):263-267.
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