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学科主题临床医学
In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China
Chen, Hongbin; Wang, Zhanwei; Li, Henan; Wang, Qi; Zhao, Chunjiang; He, Wenqiang; Wang, Xiaojuan; Zhang, Feifei; Wang, Hui
刊名JAPANESE JOURNAL OF INFECTIOUS DISEASES
2015-07-01
DOI10.7883/yoken.JJID.2014.202
68期:4页:263-267
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]URINARY-TRACT-INFECTIONS ; PSEUDOMONAS-AERUGINOSA ; LACTAMASE INHIBITOR ; ESCHERICHIA-COLI ; BIAPENEM ; RESISTANCE ; ENTEROBACTERIACEAE ; AMINOGLYCOSIDE ; ACID
英文摘要

To evaluate the in vitro antimicrobial activities of biapenem, arbekacin, and cefminox against different gram-negative bacterial isolates in China, a total of 100 non-duplicated Escherichia coli, 100 Acinetobacter baumannii, 100 Pseudomonas aeruginosa, and 99 Klebsiella pneumoniae isolates were collected from 6 teaching hospitals in China in 2012. The minimal inhibitory concentrations (MICs) of biapenem, arbekacin, cefminox and 13 other antibiotics were determined by the broth microdilution method. The carbapenems (biapenem, meropenem, and imipenem) exhibited high antimicrobial activity against E. coli (98%) and K. pneumoniae (>= 95%), followed by colistin and amikacin. The MIC50 and MIC90 of biapenem against E. coli were <= 0.06 mg/L and 0.25 mg/L, respectively. For K. pneumoniae, the MIC50, and MIC90 of biapenem were 0.25 mg/L and 1.0 mg/L, respectively. The MIC50 and MIC90 of cefminox against E. coli were 1.0 mg/L and 4.0 mg/L, respectively. The resistance rates of A. baumannii to most of the antibiotics were more than 50%, except for colistin. Amikacin was the most active antibiotic against P. aeruginosa (97%), followed by colistin (93%). The MIC50 and MIC90 of arbekacin against P. aeruginosa were 2.0 mg/L and 8.0 mg/L, respectively. In conclusion, carbapenems, colistin, amikacin, and arbekacin exhibited high antimicrobial activities against gram-negative bacteria, except A. baumannii.

语种英语
WOS记录号WOS:000359038000001
资助机构Meiji Seika Pharma Co., Ltd.
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55723
专题北京大学第二临床医学院
北京大学第二临床医学院_检验科
作者单位Peking Univ, Peoples Hosp, Dept Clin Lab, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Chen, Hongbin,Wang, Zhanwei,Li, Henan,et al. In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China[J]. JAPANESE JOURNAL OF INFECTIOUS DISEASES,2015,68(4):263-267.
APA Chen, Hongbin.,Wang, Zhanwei.,Li, Henan.,Wang, Qi.,Zhao, Chunjiang.,...&Wang, Hui.(2015).In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China.JAPANESE JOURNAL OF INFECTIOUS DISEASES,68(4),263-267.
MLA Chen, Hongbin,et al."In Vitro Analysis of Activities of 16 Antimicrobial Agents against Gram-Negative Bacteria from Six Teaching Hospitals in China".JAPANESE JOURNAL OF INFECTIOUS DISEASES 68.4(2015):263-267.
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