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学科主题: 临床医学
题名:
Natural history of infections with high-risk HPV in Chinese women with abnormal cervical cytology findings at baseline
作者: Guo, Yan-li1; You, Ke1; Qiao, Jie1; Zhao, Yi-ming2; Liu, Cong-rong3; Geng, Li1
关键词: Cervical intraepithelial neoplasia ; High-grade squamous intraepithelial lesions ; HPV ; Viral clearance ; Viral load
刊名: INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS
发表日期: 2010-08-01
DOI: 10.1016/j.ijgo.2010.03.021
卷: 110, 期:2, 页:137-140
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology
研究领域[WOS]: Obstetrics & Gynecology
关键词[WOS]: HUMAN-PAPILLOMAVIRUS INFECTION ; VIRAL LOAD ; CANCER ; NEOPLASIA ; LESIONS ; WORLDWIDE ; CELLS
英文摘要:

Objective: To clarify the natural history of disease in Chinese women with benign cytologic observation and positive for high-risk human papillomavirus (HR-HPV). Method: From September 1, 2004, to June 30, 2008, this prospective study followed up 893 women positive for HR-HPV who also had benign cytologic findings at baseline. Results: After 3 to 57 months, the viral clearance rate was higher for patients younger than 30 years and for patients who had a low viral load at baseline than for those in their comparison groups. Conversely, the occurrence rate of cervical intraepithelial neoplasia (CIN) 2 or 3 was higher for patients with persistent HR-HPV infection, those who had CIN 1 at baseline, and those whose the second viral load was increased. Conclusion: Age, viral load, and presence of CIN 1 at the first evaluation were the main factors affecting the natural history of HR-HPV infection in women with benign baseline cytologic findings. The result(s) of the second HR-HPV testing were independent indicators of histologic progression. (C) 2010 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.

语种: 英语
项目资助者: Department of Medicine
WOS记录号: WOS:000280501500014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55724
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Res Ctr Clin Epidemiol, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Guo, Yan-li,You, Ke,Qiao, Jie,et al. Natural history of infections with high-risk HPV in Chinese women with abnormal cervical cytology findings at baseline[J]. INTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS,2010,110(2):137-140.
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