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学科主题: 临床医学
题名:
Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift
作者: Sun, Jian; Jia, Yuan; Li, Ru; Guo, Jianping; Sun, Xiaolin; Liu, Yanying; Li, Yingni; Yao, Haihong; Liu, Xia; Zhao, Jing; Li, Zhanguo
关键词: altered HA peptide ; collagen-induced arthritis ; Th1/Th2
刊名: CELLULAR & MOLECULAR IMMUNOLOGY
发表日期: 2011-07-01
DOI: 10.1038/cmi.2011.5
卷: 8, 期:4, 页:348-358
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: COLLAGEN-INDUCED ARTHRITIS ; RHEUMATOID-ARTHRITIS ; II COLLAGEN ; T-CELLS ; MYASTHENIA-GRAVIS ; IMMUNE-RESPONSES ; SUPPRESSION ; ANTIBODIES ; LIGAND ; INTERLEUKIN-10
英文摘要:

There has been an increase in interest in the use of altered peptides as antigen-specific therapeutic agents in autoimmune diseases. Here we investigated the inhibitory effect and possible mechanism of an altered influenza virus haemagglutinin (HA)-derived peptide in collagen-induced arthritis (CIA). CIA was induced in DBA/1 mice by immunisation with type II collagen (CII). Altered HA308-317, wild-type HA308-317 or irrelevant peptide was administered intranasally beginning from arthritis onset. Clinical and histological scores were assessed, and cytokine levels in the serum or supernatants from splenocytes were determined. The percentages of Th1 and Th2 cells in response to different peptides were analysed by FACS both in vivo and in vitro. Our results showed that intranasal administration of altered HA308-317 peptide significantly ameliorated CIA. The therapeutic effect of altered HA308-317 peptide was associated with a substantial decrease in production of interferon (IFN)-gamma, interleukin (IL)-6, monocyte chemoattractant protein (MCP)-1, anti-CII IgG, IgG1 and IgG2a antibodies, and an markedly increase in production of IL-10 and IL-4 in serum or supernatants from splenocytes treated with altered HA308-317 peptide. The percentage of Th2 (CD4(+)IL-4(+)) cells was upregulated significantly by altered HA308-317 peptide with a decreased percentage of Th1 (T helper 1; CD4(+)INF-gamma(+)) cells both in vivo and in vitro. These findings suggest that altered HA308-317 peptide might be a promising candidate for rheumatoid arthritis (RA) treatment. Cellular & Molecular Immunology (2011) 8, 348-358; doi: 10.1038/cmi.2011.5; published online 7 March 2011

语种: 英语
所属项目编号: 2009ZX09103-746 ; 2010CB529100 ; 30700751
项目资助者: National Major Scientific and Technological Specialized Project ; National Program on Key Basic Research Project ; National Natural Science Foundation of China
WOS记录号: WOS:000292320800010
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55725
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Clin Immunol Ctr, Dept Rheumatol & Immunol, Beijing 100044, Peoples R China

Recommended Citation:
Sun, Jian,Jia, Yuan,Li, Ru,et al. Altered influenza virus haemagglutinin (HA)-derived peptide is potent therapy for CIA by inducing Th1 to Th2 shift[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2011,8(4):348-358.
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