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Integrating biomarkers in colorectal cancer trials in the West and China
Tejpar, Sabine1,2; Shen, Lin3; Wang, Xicheng3; Schilsky, Richard L.4
刊名NATURE REVIEWS CLINICAL ONCOLOGY
2015-09-01
DOI10.1038/nrclinonc.2015.88
12期:9页:553-560
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PHASE-III TRIAL ; ADVANCED GASTRIC-CANCER ; B PROTOCOL 89803 ; COLON-CANCER ; 1ST-LINE TREATMENT ; RAS MUTATIONS ; ADJUVANT TREATMENT ; PLUS CETUXIMAB ; TUMOR-MARKER ; DOUBLE-BLIND
英文摘要

The discovery of biomarkers that provide information on drug efficacy is recognized as essential for successful and cost-effective treatment of cancer. However, biomarker discovery is difficult, and requires multiple independent studies to identify a target that serves as a suitable predictor of efficacy and to ensure appropriate biomarker validation. Clinical trials that are performed, sometimes sequentially, in Europe, the USA or Asia, are often similar in their design, in part owing to regulatory, marketing, or safety considerations. We believe some of these trials offer additional unique opportunities for biomarker discovery or validation. There are multiple hurdles to overcome, such as homogenous tissue acquisition and analysis, defining and aligning biomarker hypotheses across trials, and the need to adapt sample sizes and trial designs. Nevertheless, we believe that a collaborative engagement of the academic, regulatory and pharmaceutical community can go a long way in addressing these issues and producing more-rapid results in the field of personalized medicine. In this Perspectives, we describe our views on the current fragmented approach to biomarker discovery and validation in relevant trials run within our own regions-that is, Europe, China, and the USA-and hope this article serves as a base for further reflection.

语种英语
WOS记录号WOS:000360294500008
资助机构Bayer ; Sanofi
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55727
专题北京大学临床肿瘤学院_胃肠肿瘤中心
作者单位1.Katholieke Univ Leuven, B-3000 Leuven, Belgium
2.Amer Soc Clin Oncol, Alexandria, VA 22314 USA
3.Univ Hosp Leuven, Mol Digest Oncol, B-3000 Leuven, Belgium
4.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
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GB/T 7714
Tejpar, Sabine,Shen, Lin,Wang, Xicheng,et al. Integrating biomarkers in colorectal cancer trials in the West and China[J]. NATURE REVIEWS CLINICAL ONCOLOGY,2015,12(9):553-560.
APA Tejpar, Sabine,Shen, Lin,Wang, Xicheng,&Schilsky, Richard L..(2015).Integrating biomarkers in colorectal cancer trials in the West and China.NATURE REVIEWS CLINICAL ONCOLOGY,12(9),553-560.
MLA Tejpar, Sabine,et al."Integrating biomarkers in colorectal cancer trials in the West and China".NATURE REVIEWS CLINICAL ONCOLOGY 12.9(2015):553-560.
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