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学科主题: 临床医学
题名:
Integrating biomarkers in colorectal cancer trials in the West and China
作者: Tejpar, Sabine1,2; Shen, Lin3; Wang, Xicheng3; Schilsky, Richard L.4
刊名: NATURE REVIEWS CLINICAL ONCOLOGY
发表日期: 2015-09-01
DOI: 10.1038/nrclinonc.2015.88
卷: 12, 期:9, 页:553-560
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PHASE-III TRIAL ; ADVANCED GASTRIC-CANCER ; B PROTOCOL 89803 ; COLON-CANCER ; 1ST-LINE TREATMENT ; RAS MUTATIONS ; ADJUVANT TREATMENT ; PLUS CETUXIMAB ; TUMOR-MARKER ; DOUBLE-BLIND
英文摘要:

The discovery of biomarkers that provide information on drug efficacy is recognized as essential for successful and cost-effective treatment of cancer. However, biomarker discovery is difficult, and requires multiple independent studies to identify a target that serves as a suitable predictor of efficacy and to ensure appropriate biomarker validation. Clinical trials that are performed, sometimes sequentially, in Europe, the USA or Asia, are often similar in their design, in part owing to regulatory, marketing, or safety considerations. We believe some of these trials offer additional unique opportunities for biomarker discovery or validation. There are multiple hurdles to overcome, such as homogenous tissue acquisition and analysis, defining and aligning biomarker hypotheses across trials, and the need to adapt sample sizes and trial designs. Nevertheless, we believe that a collaborative engagement of the academic, regulatory and pharmaceutical community can go a long way in addressing these issues and producing more-rapid results in the field of personalized medicine. In this Perspectives, we describe our views on the current fragmented approach to biomarker discovery and validation in relevant trials run within our own regions-that is, Europe, China, and the USA-and hope this article serves as a base for further reflection.

语种: 英语
项目资助者: Bayer ; Sanofi
WOS记录号: WOS:000360294500008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55727
Appears in Collections:北京大学临床肿瘤学院_胃肠肿瘤中心_期刊论文

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作者单位: 1.Katholieke Univ Leuven, B-3000 Leuven, Belgium
2.Amer Soc Clin Oncol, Alexandria, VA 22314 USA
3.Univ Hosp Leuven, Mol Digest Oncol, B-3000 Leuven, Belgium
4.Peking Univ, Canc Hosp & Inst, Dept Gastrointestinal Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China

Recommended Citation:
Tejpar, Sabine,Shen, Lin,Wang, Xicheng,et al. Integrating biomarkers in colorectal cancer trials in the West and China[J]. NATURE REVIEWS CLINICAL ONCOLOGY,2015,12(9):553-560.
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