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学科主题: 临床医学
题名:
The predictive values of beta(1)-adrenergic and M-2 muscarinic receptor autoantibodies for sudden cardiac death in patients with chronic heart failure
作者: Pei, Juanhui2,3,4; Li, Ning2,3,4; Chen, Jingzhou2,3,4; Li, Xian2,3,4; Zhang, Yinhui2,3,4; Wang, Zengwu2,3,4; Zhang, Ping1; Cao, Kejiang5; Pu, Jielin2,3,4
关键词: Beta(1)-adrenergic receptor ; M-2 muscarinic receptor ; Autoantibody ; Chronic heart failure ; Sudden cardiac death
刊名: EUROPEAN JOURNAL OF HEART FAILURE
发表日期: 2012-08-01
DOI: 10.1093/eurjhf/hfs082
卷: 14, 期:8, 页:887-894
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cardiac & Cardiovascular Systems
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: IDIOPATHIC DILATED CARDIOMYOPATHY ; UNSUSTAINED TACHYCARDIA TRIAL ; 2ND EXTRACELLULAR LOOP ; VENTRICULAR-TACHYCARDIA ; TROPONIN-I ; ANTIBODIES ; IMMUNOADSORPTION ; DISEASE ; ARRHYTHMIAS ; MORTALITY
英文摘要:

Clinical and animal studies suggest that beta(1)-adrenergic and M-2 muscarinic receptor autoantibodies (beta(1)-AAbs and M-2-AAbs) play important roles in the pathophysiological process of chronic heart failure (CHF). Removal of these autoantibodies improved haemodynamic parameters and left ventricular ejection fraction patients with CHF. The goal of this project is to evaluate whether beta(1)-AAbs and M-2-AAbs predict prognosis and sudden cardiac death (SCD) in CHF.

A total of 2062 patients with CHF and 824 control subjects were recruited. Beta(1)-AAbs and M-2-AAbs were detected by the enzyme-linked immunosorbent assay (ELISA) method, and the correlation between these autoantibodies and the prognosis of CHF was analysed. During a median follow-up period of 36 months (0.40 65 months), 379 (21.56) cases died164 had dilated cardiomyopathy (DCM) and 215 had ischaemic cardiomyopathy (ICM). Of these, SCD occurred in 69 cases (40.37) of DCM and in 84 cases (39.07) of ICM. Positivity for beta(1)-AAbs in DCM and ICM was significantly higher than for the controls (8.1 and 8.25 v.s 2.2, both P 0.01). However, positive M-2-AAbs did not show any statistical difference between the three groups. Cox regression analysis revealed that positive beta(1)-AAbs were associated with higher mortality in CHF and that it predicted SCD for DCM [hazard ratio (HR) 4.51, 95 confidence interval (CI) 2.4058.471] and ICM (HR 3.749, 95 CI 2.3895.884) patients, but not non-SCD (NSCD) patients.

The rates of positive beta(1)-AAbs were higher in CHF patients than in the controls. Positive beta(1)-AAbs might serve as an independent predictor for SCD in patients with CHF.

语种: 英语
所属项目编号: 2007CB512000 ; 2007CB512008
项目资助者: National Basic Research Program of China [973 program]
WOS记录号: WOS:000306924900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55730
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
2.First Peoples Hosp Jiangsu Prov, Nanjing, Jiangsu, Peoples R China
3.Chinese Acad Med Sci, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China
4.Chinese Acad Med Sci, Cardiovasc Inst, Beijing 100730, Peoples R China
5.Peking Union Med Coll, Beijing 100021, Peoples R China

Recommended Citation:
Pei, Juanhui,Li, Ning,Chen, Jingzhou,et al. The predictive values of beta(1)-adrenergic and M-2 muscarinic receptor autoantibodies for sudden cardiac death in patients with chronic heart failure[J]. EUROPEAN JOURNAL OF HEART FAILURE,2012,14(8):887-894.
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