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学科主题: 临床医学
题名:
Therapeutic effects of ghrelin on endotoxic shock in rats
作者: Chang, L; Zhao, J; Yang, J; Zhang, ZK; Du, JB; Tang, CS
关键词: endotoxic shock ; hemodynamics ; ghrelin
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2003-07-25
DOI: 10.1016/S0014-2999(03)01972-1
卷: 473, 期:2-3, 页:171-176
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: GROWTH-HORMONE SECRETAGOGUE ; CHRONIC HEART-FAILURE ; VENTRICULAR DYSFUNCTION ; INSULIN-SECRETION ; ACYLATED PEPTIDE ; ENDOCRINE ; STOMACH ; HEXARELIN ; CACHEXIA ; CELLS
英文摘要:

We investigated the effects of ghrelin in a rat endotoxic shock model, and also observed the direct role of endotoxin on ghrelin generation in gastric mucosa. About 55% (11/20) of rats treated with lipopolysaccharide (5 mg/kg i.v.) alone died within 24 h of endotoxin injection. However, administration of ghrelin either at the same time as lipopolysaccharide injection (early treatment) or 12 h after lipopolysaccharide injection (late treatment) significantly decreased the mortality rate and ameliorated the hypotension seen in rats with endotoxic shock. Early and late treatment with ghrelin increased markedly the plasma glucose concentration and decreased the plasma lactate concentration. Early treatment with ghrelin attenuated significantly the deficiency in myocardial ATP content, but late treatment with ghrelin had no effect on myocardial ATP content. The plasma ghrelin level was significantly increased in the rats with endotoxin shock, and it increased further after ghrelin administration. Exposure of rat gastric mucosa in vitro to lipopolysaccharide (1.0 to 100 mug/ml) triggered the release of ghrelin from mucosa tissue in a dose- and time-dependent manner, meaning that lipopolysaccharide stimulated directly gastric mucosa to synthesize and secrete ghrelin. The results suggest that ghrelin could have therapeutic value for endotoxic shock. (C) 2003 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000184564900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55731
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: 1.Phoenix Pharmacert Inc, Belmont, CA 94002 USA
2.Peking Univ, Hosp 1, Cardiovasc Res Inst, Beijing 100034, Peoples R China
3.Peking Univ, Ctr Hlth, Dept Physiol & Pathophysiol, Beijing 100083, Peoples R China
4.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China

Recommended Citation:
Chang, L,Zhao, J,Yang, J,et al. Therapeutic effects of ghrelin on endotoxic shock in rats[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2003,473(2-3):171-176.
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