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Magnetic bead-based salivary peptidome profiling analysis during orthodontic treatment durations
Zhang, Jieni2; Zhou, Shaonan2; Zheng, Hui2; Zhou, Yanheng2; Chen, Feng1; Lin, Jiuxiang2
关键词Orthodontic Treatment Duration Peptidome Saliva Maldi-tof Ms
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2012-05-18
DOI10.1016/j.bbrc.2012.04.100
421期:4页:844-849
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]BREAST-CANCER PATIENTS ; BIOMARKER DISCOVERY ; TOOTH MOVEMENT ; MASS-SPECTROMETRY ; PROTEOMICS ; OBESITY ; STAGE
英文摘要

Orthodontic treatment induces various biological responses, including tooth movement and remodeling of alveolar bone. Although some studies have investigated the contribution of orthodontic procedures to changes in saliva conditions, little is known about the effects of different treatment durations on the saliva proteome. To identify the discriminating protein profiles in unstimulated whole saliva of orthodontic patients with different treatment durations, we used matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) combined with magnetic bead, and peptide mass fingerprints were created by scanning MS signals. Saliva samples from 40 patients (10 in each of four groups: the group without an appliance and groups under treatment for 2, 7, and 12 months) were analyzed. The results showed eight mass peaks with significant differences. Furthermore, mass peak intensities at proteins 1817.7, 2010.7, 2744 and 2710.2 Da represented a steady time-dependent increasing trend, whereas protein 4134 Da exhibited a decreasing tendency. Differential expression of the peptidome profile also occurred in the multiple comparisons, and we established a fitting model. Thus, the potential discriminating biomarkers investigated in this study reflected the complicated changes in periodontal tissues during orthodontic treatment and indicated dynamic interactions between orthodontic treatment and the saliva proteome. The results provide novel insights into alterations in salivary proteins due to different orthodontic treatment durations and may lead to the development of a therapeutic monitoring strategy for orthodontics. (C) 2012 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000305168600036
项目编号PKUSS20110301
资助机构Peking University School of Stomatology
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55734
专题北京大学口腔医学院
北京大学口腔医学院_口腔正畸科
作者单位1.Peking Univ, Sch Stomatol, Cent Lab, Beijing 100081, Peoples R China
2.Peking Univ, Sch Stomatol, Dept Orthodont, Beijing 100081, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jieni,Zhou, Shaonan,Zheng, Hui,et al. Magnetic bead-based salivary peptidome profiling analysis during orthodontic treatment durations[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2012,421(4):844-849.
APA Zhang, Jieni,Zhou, Shaonan,Zheng, Hui,Zhou, Yanheng,Chen, Feng,&Lin, Jiuxiang.(2012).Magnetic bead-based salivary peptidome profiling analysis during orthodontic treatment durations.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,421(4),844-849.
MLA Zhang, Jieni,et al."Magnetic bead-based salivary peptidome profiling analysis during orthodontic treatment durations".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 421.4(2012):844-849.
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