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学科主题: 药学
题名:
Recent development in the design of sialyltransferase inhibitors
作者: Wang, XF; Zhang, LH; Ye, XS
关键词: sialyltransferase ; inhibitor ; carbohydrate mimetics ; structure-activity relationship ; review
刊名: MEDICINAL RESEARCH REVIEWS
发表日期: 2003
卷: 23, 期:1, 页:32-47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TRANSITION-STATE ANALOGS ; RAT-LIVER ; SIALYL DONOR ; OXOCARBENIUM ION ; ACID ; POTENT ; ALPHA-2,6-SIALYLTRANSFERASE ; GLYCOSYLATION ; SUBSTRATE ; GLYCOSYLTRANSFERASES
英文摘要:

Sialylation at the non-reducing end of glycoconjugates is an important biological process in cellular recognitions, tumor metastases, and immune responses, which are mediated by a family of enzymes known as sialyltransferases. Inhibition of sialyltransferases may prove useful in elucidating the biological functions of sialylation and may have therapeutic applications. This review summarizes the recent development in this field with particular focus on the strategies used for the design of carbohydrate mimetics and the structure-activity relationships of substrate-based sialyltransferase inhibitors. (C) 2002 Wiley Periodicals, Inc.

语种: 英语
WOS记录号: WOS:000179843600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55739
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

Recommended Citation:
Wang, XF,Zhang, LH,Ye, XS. Recent development in the design of sialyltransferase inhibitors[J]. MEDICINAL RESEARCH REVIEWS,2003,23(1):32-47.
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