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Recent development in the design of sialyltransferase inhibitors
Wang, XF; Zhang, LH; Ye, XS
关键词Sialyltransferase Inhibitor Carbohydrate Mimetics Structure-activity Relationship Review
刊名MEDICINAL RESEARCH REVIEWS
2003
23期:1页:32-47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TRANSITION-STATE ANALOGS ; RAT-LIVER ; SIALYL DONOR ; OXOCARBENIUM ION ; ACID ; POTENT ; ALPHA-2,6-SIALYLTRANSFERASE ; GLYCOSYLATION ; SUBSTRATE ; GLYCOSYLTRANSFERASES
英文摘要

Sialylation at the non-reducing end of glycoconjugates is an important biological process in cellular recognitions, tumor metastases, and immune responses, which are mediated by a family of enzymes known as sialyltransferases. Inhibition of sialyltransferases may prove useful in elucidating the biological functions of sialylation and may have therapeutic applications. This review summarizes the recent development in this field with particular focus on the strategies used for the design of carbohydrate mimetics and the structure-activity relationships of substrate-based sialyltransferase inhibitors. (C) 2002 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000179843600003
引用统计
被引频次:35[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55739
专题北京大学药学院
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
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GB/T 7714
Wang, XF,Zhang, LH,Ye, XS. Recent development in the design of sialyltransferase inhibitors[J]. MEDICINAL RESEARCH REVIEWS,2003,23(1):32-47.
APA Wang, XF,Zhang, LH,&Ye, XS.(2003).Recent development in the design of sialyltransferase inhibitors.MEDICINAL RESEARCH REVIEWS,23(1),32-47.
MLA Wang, XF,et al."Recent development in the design of sialyltransferase inhibitors".MEDICINAL RESEARCH REVIEWS 23.1(2003):32-47.
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