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学科主题基础医学
Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats
Liu, Min1,2; Yang, Huan1; Fang, Dong1; Yang, Jing-Jing1; Cai, Jie1,2; Wan, You1,2,3,4; Chui, De-Hua1,2; Han, Ji-Sheng1,2,3,4; Xing, Guo-Gang1,2,3,4
关键词Bone cancer pain Dorsal root ganglion Hyperexcitability Neuronal calcium sensor protein VILIP-1 P2X3 receptors
刊名PAIN
2013-09-01
DOI10.1016/j.pain.2013.04.022
154期:9页:1551-1568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Anesthesiology ; Clinical Neurology ; Neurosciences
研究领域[WOS]Anesthesiology ; Neurosciences & Neurology
关键词[WOS]SPINAL NERVE LIGATION ; NR2B-CONTAINING NMDA RECEPTORS ; NEUROPATHIC PAIN ; DIFFERENTIAL REGULATION ; HIPPOCAMPAL-NEURONS ; MEDIATED RESPONSES ; P2X(3) RECEPTORS ; SODIUM CURRENTS ; ADULT RATS ; ACTIVATION
英文摘要

Primary and metastatic cancers that affect bone are frequently associated with severe and intractable pain. The mechanisms underlying the development of bone cancer pain are largely unknown. In this study, we first demonstrated that a functional upregulation of P2X3 receptors in dorsal root ganglion (DRG) neurons is closely associated with the neuronal hyperexcitability and the cancer-induced bone pain in MRMT-1 tumor cell-inoculated rats. Second, we revealed that visinin-like protein 1 (VILIP-1), a member of visinin-like proteins that belong to the family of neuronal calcium sensor proteins is responsible for the observed upregulation of P2X3 receptors in DRG neurons. The interaction between the amino terminus of VLIP-1 and the carboxyl terminus of the P2X3 receptor is critical for the surface expression and functional enhancement of the receptor. Finally, overexpression of VILIP-1 increases the expression of functional P2X3 receptors and enhances the neuronal excitability in naive rat DRG neurons. In contrast, knockdown of VILIP-1 inhibits the development of bone cancer pain via downregulation of P2X3 receptors and repression of DRG excitability in MRMT-1 rats. Taken together, these results suggest that functional upregulation of P2X3 receptors by VILIP-1 in DRG neurons contributes to the development of cancer-induced bone pain in MRMT-1 rats. Hence, P2X3 receptors and VILIP-1 could serve as potential targets for therapeutic interventions in cancer patients for pain management. Pharmacological blockade of P2X3 receptors or knockdown of VILIP-1 in DRGs would be used as innovative strategies for the treatment of bone cancer pain. (c) 2013 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000323600000012
项目编号31171063 ; 81072951 ; 61027001 ; 7112079 ; 201302013-01 ; 2013CB531905
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; special foundation for public welfare profession scientific research program from Ministry of Health of the Peoples Republic of China ; 973 Program of the Ministry of Science and Technology of China
引用统计
被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55740
专题北京大学基础医学院_神经生物学系
北京大学基础医学院
北京大学口腔医学院_综合治疗科
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Minist Educ, Key Lab Neurosci, Beijing, Peoples R China
3.Minist Hlth, Beijing, Peoples R China
4.Peking Univ Hlth Sci Ctr, Sch Basic Med Sci, Dept Neurobiol, Beijing, Peoples R China
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GB/T 7714
Liu, Min,Yang, Huan,Fang, Dong,et al. Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats[J]. PAIN,2013,154(9):1551-1568.
APA Liu, Min.,Yang, Huan.,Fang, Dong.,Yang, Jing-Jing.,Cai, Jie.,...&Xing, Guo-Gang.(2013).Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats.PAIN,154(9),1551-1568.
MLA Liu, Min,et al."Upregulation of P2X3 receptors by neuronal calcium sensor protein VILIP-1 in dorsal root ganglions contributes to the bone cancer pain in rats".PAIN 154.9(2013):1551-1568.
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