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学科主题: 临床医学
题名:
beta-CTX and CTP act as indicators of skeletal metastasis status in mace patients with non-small cell bung cancer
作者: Kong, Q. Q.; Sun, T. W.; Dou, Q. Y.; Li, F.; Tang, Q.; Pei, F. X.; Tu, C. Q.; Chen, Z. Q.
关键词: bone biochemical markers ; bone turnover ; bone metastases ; bone resorption ; non-small cell lung cancer
刊名: INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
发表日期: 2007-07-01
卷: 22, 期:3, 页:214-220
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Oncology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]: LUNG-CANCER ; BREAST-CANCER ; COLLAGEN DEGRADATION ; BONE METASTASES ; PROSTATE-CANCER ; MARKERS ; ICTP ; CARCINOMA ; DIAGNOSIS ; DISEASE
英文摘要:

Bone metastasis is common in lung cancer patients and associated with reduced quality of life and reduced overall and median survival, so the early detection of bone metastasis and monitoring of its status is very important for clinicians. Serum bone-specific alkaline phosphatase (BAP), osteocalcin (OC), beta isomer of C-terminal telopeptide of type I collagen (beta-CTX) and cross-linked C-terminal telopeptide (if type I collagen (ICTP) were compared with regard to their usefulness as indicators of bone metastasis in lung cancer. The serum concentrations of the 4 markers were measured by commercially available tests in 96 male patients with non-small cell lung cancer and 30 male patients with other pulmonary diseases. The levels of both beta-CTX and ICTP were significantly higher in 61 lung cancer patients with bone metastases than in 35 lung cancer patients without bone metastases (both p<0.001), and significantly correlated with the extent of bone disease. Although ICTP had a better sensitivity and accuracy than beta-CTX (75.4% vs 65.6% and 72.9% vs 68.8%, respectively), they had a similar area under the receiver operating characteristic curve (0.85 vs 0.83). These results support the use of beta-CTX and ICTP as an adjunct tool for the diagnosis and screening of bone metastasis in lung cancer.

语种: 英语
WOS记录号: WOS:000250995800009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55742
Appears in Collections:北京大学第三临床医学院_骨科_期刊论文

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作者单位: 1.Tianjin Union Med Ctr, Dept Spine Surg, Tianjin, Peoples R China
2.Tianjin Med Ctr, Dept Resp Med, Tianjin, Peoples R China
3.Peking Univ Third Hosp, Dept Orthoped Surg, Beijing 100082, Peoples R China
4.Sichuan Univ, W China Hosp, Dept Orthoped Surg, Chengdu 610041, Peoples R China
5.Sichuan Univ, W China Hosp, Dept Hematol, Chengdu, Peoples R China

Recommended Citation:
Kong, Q. Q.,Sun, T. W.,Dou, Q. Y.,et al. beta-CTX and CTP act as indicators of skeletal metastasis status in mace patients with non-small cell bung cancer[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2007,22(3):214-220.
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