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学科主题临床医学
High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia
Xu, Lan-Ping; Luo, Xiao-Hua; Chang, Ying-Jun; Liu, Dai-Hong; Liu, Kai-Yan; Chen, Yu-Hong; Huang, Xiao-Jun
关键词Hematopoietic Stem Cell Transplantation Chronic Myeloid Leukemia Hla-mismatched Haploidentical Allograft Cd4/cd8 Ratio
刊名ANNALS OF HEMATOLOGY
2009-10-01
DOI10.1007/s00277-009-0728-4
88期:10页:1015-1024
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology
研究领域[WOS]Hematology
关键词[WOS]VERSUS-HOST-DISEASE ; COLONY-STIMULATING FACTOR ; BONE-MARROW-TRANSPLANTATION ; IDENTICAL SIBLING TRANSPLANTATION ; 1ST COMPLETE REMISSION ; CHRONIC GRAFT ; T-CELLS ; G-CSF ; HEMATOLOGIC MALIGNANCIES ; ANTITHYMOCYTE GLOBULIN
英文摘要

HLA-mismatched/haploidentical hematopoietic stem cell transplantation (haplo-mismatched HSCT) has improved the outcome of chronic myeloid leukemia (CML) in patients without an HLA-matched donor. To further improve the treatment outcome of haplo-mismatched HSCT in CML, a modifiable prognostic factor needs to be found. The cellular composition of grafts obtained from 75 HLA-mismatched/haploidentical related donors was prospectively correlated with the outcome of patients with CML undergoing haplo-mismatched HSCT following a modified regimen of BU/CY 2 plus antithymocyte globulin. The concentration of T-cell subsets, CD14+, and CD34+ cells and their relative proportions were analyzed. In univariate analyses, disease-free survival (DFS) and overall survival (OS) conversely correlated with the CD4/CD8 ratio in primed bone marrow graft (G-BM) (p = 0.012 and p = 0.040); similarly, CD4/CD8 ratio in total grafts was also negatively associated with DFS and OS (p = 0.018 and p = 0.020). In multivariate analyses, a CD4/CD8 ratio in G-BM higher than the median value remained the only factor negatively affecting DFS (p = 0.030; 95% confidence interval [CI], 1.166-19.341). Expectedly, high CD34+ cell dose was associated with accelerated platelet engraftment (p = 0.009; 95% CI = 1.181-3.271) after controlling for a high risk of disease. No other clinical parameter was influenced by graft composition. Our results suggest that a high CD4/CD8 ratio in allografts may predict adverse survival in patients with CML undergoing haplo-mismatched HSCT.

语种英语
WOS记录号WOS:000269109900013
项目编号2006AA02Z4A0 ; 30725038 ; IRT0702
资助机构Hi-Tech Research and Development Program of China ; China National Funds forDistinguished Young Scientist&prime ; s ; Funds for Creative Research Groups of China
引用统计
被引频次:12[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55745
专题北京大学第二临床医学院_血液科
作者单位Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China
推荐引用方式
GB/T 7714
Xu, Lan-Ping,Luo, Xiao-Hua,Chang, Ying-Jun,et al. High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia[J]. ANNALS OF HEMATOLOGY,2009,88(10):1015-1024.
APA Xu, Lan-Ping.,Luo, Xiao-Hua.,Chang, Ying-Jun.,Liu, Dai-Hong.,Liu, Kai-Yan.,...&Huang, Xiao-Jun.(2009).High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia.ANNALS OF HEMATOLOGY,88(10),1015-1024.
MLA Xu, Lan-Ping,et al."High CD4/CD8 ratio in allografts predicts adverse outcomes in unmanipulated HLA-mismatched/haploidentical hematopoietic stem cell transplantation for chronic myeloid leukemia".ANNALS OF HEMATOLOGY 88.10(2009):1015-1024.
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