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学科主题基础医学
Repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia and suppression of spinal release of substance P in monoarthritic rats
Liu, Hong-Xiang; Tian, Jin-Bin; Luo, Fei; Jiang, Yu-Hui; Deng, Zu-Guo; Xiong, Liang; Liu, Cheng; Wang, Jin-Shu; Han, Ji-Sheng
关键词Chronic Inflammatory Hyperalgesia Freund&Prime s Adjuvant Monoarthritis Substance p Transcutaneous Electrical Nerve Stimulation (Tens)
刊名EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
2007-03-01
DOI10.1093/ecam/nel056
4期:1页:65-75
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
关键词[WOS]ELECTRICAL NERVE-STIMULATION ; ADJUVANT-INDUCED ARTHRITIS ; OSTEOARTHRITIC KNEE PAIN ; HIGH-FREQUENCY TENS ; DORSAL HORN CELLS ; NEUROPATHIC PAIN ; INDUCED ANTIHYPERALGESIA ; SEROTONERGIC RECEPTORS ; VARYING FREQUENCY ; ELECTROACUPUNCTURE
英文摘要

Transcutaneous electrical nerve stimulation (TENS) has been shown to be an effective measure for pain relief The aim of the present study was to determine the optimal intensity and interval of repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia in a monoarthritic pain model of the rat, and to assess the changes of the spinal substance P (SP) release in response to TENS treatment. A reliable, reproducible chronic monoarthritic pain model was produced by intra-articular injection of complete Freund′s adjuvant (CFA) at single ankle joint. The efficacy of 100 Hz TENS treatments with different frequencies and intensities was compared. In the acute period (within 3 weeks) of monoarthritis, twice-a-week schedule of TENS reduced the swelling of the inflamed ankle significantly. In the stable period (4-9 weeks), however, once-a-week schedule produced a significantly better therapeutic effect on both inflammation and arthritic hyperalgesia than that of twice- or five-times-a-week schedule. Using three levels of intensity of TENS, we found that the weaker (1-1-2 mA) stimulation produced significantly better therapeutic effects. Repeated TENS produced a reduction of SP content in spinal perfusate in parallel with the progressive reduction of the arthritic pain scores. Our results suggest that (i) consecutive TENS treatments produced cumulative effect for chronic hyperalgesia, (ii) for chronic inflammatory hyperalgesia, a weaker intensity and more sparsely arranged treatment schedule may produce better therapeutic effect and (iii) a decrease in SP release may serve as one of the possible neurochemical mechanisms underlying the therapeutic effects of multiple TENS treatments on chronic inflammatory hyperalgesia.

语种英语
WOS记录号WOS:000245550900010
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55749
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Key Lab Neurosci,Minist Educ, Beijing 100083, Peoples R China
2.Minist Publ Hlth, Beijing 100083, Peoples R China
3.Zhengzhou Univ, Sch Med, Dept Physiol & Neurobiol, Zhengzhou 450052, Peoples R China
4.Peking Univ, Teaching Hosp 3, Dept Radiol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Liu, Hong-Xiang,Tian, Jin-Bin,Luo, Fei,et al. Repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia and suppression of spinal release of substance P in monoarthritic rats[J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,2007,4(1):65-75.
APA Liu, Hong-Xiang.,Tian, Jin-Bin.,Luo, Fei.,Jiang, Yu-Hui.,Deng, Zu-Guo.,...&Han, Ji-Sheng.(2007).Repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia and suppression of spinal release of substance P in monoarthritic rats.EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE,4(1),65-75.
MLA Liu, Hong-Xiang,et al."Repeated 100 Hz TENS for the treatment of chronic inflammatory hyperalgesia and suppression of spinal release of substance P in monoarthritic rats".EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE 4.1(2007):65-75.
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