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Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry
Li, Bin1; Zhang, Xu1; Wang, Juan1; Zhang, Le1; Gao, Bowen1; Shi, Shepo1; Wang, Xiaohui1; Li, Jun1; Tu, Pengfei1,2
关键词Coumarin Angelica Dahurica Spirobifuranocoumarin Off-line 2d-hplc-esi/msn Furanocoumarins
刊名PHYTOCHEMICAL ANALYSIS
2014-05-01
DOI10.1002/pca.2496
25期:3页:229-240
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemical Research Methods ; Plant Sciences ; Chemistry, Analytical
研究领域[WOS]Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry
关键词[WOS]PLEUROSPERMUM-RIVULORUM ; ION SUPPRESSION ; FURANOCOUMARINS ; IDENTIFICATION ; COMPONENTS ; SEPARATION ; MEDICINE ; CELLS ; CYCLOOXYGENASE-2 ; FUROCOUMARINS
英文摘要

Introduction

The root of Angelica dahurica is a traditional Chinese medicine that used for the treatment of headache, toothache, abscess, furunculosis and acne. Coumarins were the major bioactive constituents of A. dahurica, hence it is worthwhile developing a method to simultaneously characterise them, especially those in trace amounts.

Objective

To develop an efficient method for the simultaneous characterisation of coumarins in A. dahurica.

Methods

A method using off-line two-dimensional high-performance liquid chromatography coupled with electrospray tandem mass spectrometry (off-line 2D-HPLC-ESI/MSn) was developed.

Results

In total 50 coumarins, including 32 linear furanocoumarins, 16 bifuranocoumarins and two non-furanocoumarins, were identified from the roots of A. dahurica. The possible MS fragmentations of these coumarins are also proposed.

Conclusion

The method described here allows rapid and convenient identification of the coumarins in A. dahurica, and may be applied to other herbal medicines containing linear furanocoumarins. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000334286600007
项目编号NCET-11-0604 ; 2013-JYBZZ-XS-111 ; 5132022
资助机构Trans-Century Training Program Foundation for the Talents of Humanities and Social Science by the State Education Commission ; Postgraduate Foundation of Beijing University of Chinese Medicine ; Beijing Natural Science Foundation
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55756
专题北京大学药学院
北京大学药学院_天然药物学系
通讯作者Shi, Shepo
作者单位1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Li, Bin,Zhang, Xu,Wang, Juan,et al. Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry[J]. PHYTOCHEMICAL ANALYSIS,2014,25(3):229-240.
APA Li, Bin.,Zhang, Xu.,Wang, Juan.,Zhang, Le.,Gao, Bowen.,...&Tu, Pengfei.(2014).Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry.PHYTOCHEMICAL ANALYSIS,25(3),229-240.
MLA Li, Bin,et al."Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry".PHYTOCHEMICAL ANALYSIS 25.3(2014):229-240.
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