北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学药学院  > 期刊论文
学科主题: 药学
题名:
Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry
作者: Li, Bin1; Zhang, Xu1; Wang, Juan1; Zhang, Le1; Gao, Bowen1; Shi, Shepo1; Wang, Xiaohui1; Li, Jun1; Tu, Pengfei1,2
关键词: coumarin ; Angelica dahurica ; spirobifuranocoumarin ; Off-line 2D-HPLC-ESI/MSn ; furanocoumarins
刊名: PHYTOCHEMICAL ANALYSIS
发表日期: 2014-05-01
DOI: 10.1002/pca.2496
卷: 25, 期:3, 页:229-240
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Plant Sciences ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Plant Sciences ; Chemistry
关键词[WOS]: PLEUROSPERMUM-RIVULORUM ; ION SUPPRESSION ; FURANOCOUMARINS ; IDENTIFICATION ; COMPONENTS ; SEPARATION ; MEDICINE ; CELLS ; CYCLOOXYGENASE-2 ; FUROCOUMARINS
英文摘要:

Introduction

The root of Angelica dahurica is a traditional Chinese medicine that used for the treatment of headache, toothache, abscess, furunculosis and acne. Coumarins were the major bioactive constituents of A. dahurica, hence it is worthwhile developing a method to simultaneously characterise them, especially those in trace amounts.

Objective

To develop an efficient method for the simultaneous characterisation of coumarins in A. dahurica.

Methods

A method using off-line two-dimensional high-performance liquid chromatography coupled with electrospray tandem mass spectrometry (off-line 2D-HPLC-ESI/MSn) was developed.

Results

In total 50 coumarins, including 32 linear furanocoumarins, 16 bifuranocoumarins and two non-furanocoumarins, were identified from the roots of A. dahurica. The possible MS fragmentations of these coumarins are also proposed.

Conclusion

The method described here allows rapid and convenient identification of the coumarins in A. dahurica, and may be applied to other herbal medicines containing linear furanocoumarins. Copyright (c) 2014 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: NCET-11-0604 ; 2013-JYBZZ-XS-111 ; 5132022
项目资助者: Trans-Century Training Program Foundation for the Talents of Humanities and Social Science by the State Education Commission ; Postgraduate Foundation of Beijing University of Chinese Medicine ; Beijing Natural Science Foundation
WOS记录号: WOS:000334286600007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55756
Appears in Collections:北京大学药学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing 100029, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Hlth Sci Ctr, Beijing 100191, Peoples R China

Recommended Citation:
Li, Bin,Zhang, Xu,Wang, Juan,et al. Simultaneous Characterisation of Fifty Coumarins from the Roots of Angelica dahurica by Off-line Two-dimensional High-performance Liquid Chromatography Coupled with Electrospray Ionisation Tandem Mass Spectrometry[J]. PHYTOCHEMICAL ANALYSIS,2014,25(3):229-240.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Li, Bin]'s Articles
[Zhang, Xu]'s Articles
[Wang, Juan]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Li, Bin]‘s Articles
[Zhang, Xu]‘s Articles
[Wang, Juan]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace