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学科主题: 临床医学
题名:
Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia - Feasibility and safety study
作者: Huang, Xiao-Jun; Wang, Yu; Liu, Dai-Hong; Xu, Lan-Ping; Chen, Huan; Chen, Yu-Hong; Han, Wei; Shi, Hong-Xia; Liu, Kai-Yan
关键词: advanced leukemia ; donor lymphocytes infusion ; granulocyte colony-stimulating factor ; hematopoietic stem cell transplantation
刊名: JOURNAL OF CLINICAL IMMUNOLOGY
发表日期: 2008-07-01
DOI: 10.1007/s10875-008-9193-4
卷: 28, 期:4, 页:390-397
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Immunology
研究领域[WOS]: Immunology
关键词[WOS]: BONE-MARROW-TRANSPLANTATION ; ACUTE MYELOID-LEUKEMIA ; COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; CHEMOTHERAPY ; MALIGNANCIES ; REMISSION
英文摘要:

Purpose We retrospectively evaluated the feasibility and safety of a modified prophylactic donor lymphocytes infusion (DLI) approach in advanced leukemia.

Materials and methods Thirty-three patients with advanced leukemia received modified prophylactic DLI; that is, granulocyte colony-stimulating factor-primed peripheral blood progenitor cells instead of steady-donor lymphocyte harvests were used, and a short-term immunosuppressive agent (cyclosporine A or methotrexate 10 mg once per week for 2 to 4 weeks) was used for prevention of DLI-associated graft versus host disease (GVHD) after human leukocyte antigen-identical sibling hematopoietic stem cell transplantation.

Results Thirty-nine infusions were performed in 33 patients. The mononuclear cells and median CD3+ cells infused for DLI were 1-2x10(8) and 0.93x10(6) per kilogram, respectively. Six patients experienced II-IV-grade acute GVHD. Twenty patients developed chronic GVHD. No GVHD-related death or transfusion-related pancytopenia was observed. With an 18-month median follow-up, 16 patients were in disease-free survival, and overall survival at 1 and 1.5 years was 69.0% and 50.2%, respectively.

Conclusions The modified prophylactic DLI strategy might represent a step forward in the treatment of advanced leukemia.

语种: 英语
WOS记录号: WOS:000257456500015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55757
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Huang, Xiao-Jun,Wang, Yu,Liu, Dai-Hong,et al. Modified donor lymphocyte infusion (DLI) for the prophylaxis of leukemia relapse after hematopoietic stem cell transplantation in patients with advanced leukemia - Feasibility and safety study[J]. JOURNAL OF CLINICAL IMMUNOLOGY,2008,28(4):390-397.
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