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学科主题: 公共卫生
题名:
Detection of enterovirus 68 as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China
作者: Lu, Qing-Bin1; Wo, Ying2; Wang, Hong-Yu2; Wei, Mao-Ti2; Zhang, Lei2; Yang, Hong2; Liu, En-Mei3; Li, Ting-Yu3; Zhao, Zhong-Tang4; Liu, Wei2; Cao, Wu-Chun2
刊名: JOURNAL OF MEDICAL MICROBIOLOGY
发表日期: 2014-03-01
DOI: 10.1099/jmm.0.068247-0
卷: 63, 页:408-414
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Microbiology
研究领域[WOS]: Microbiology
关键词[WOS]: COXSACKIEVIRUS A21 ; CHILDREN ; PICORNAVIRUSES ; RHINOVIRUSES ; ILLNESS ; VIRUS ; BRONCHIOLITIS ; EMERGENCE ; INFANTS
英文摘要:

Human enterovirus 68 (HEV-68) is an enterovirus associated with respiratory illness. In China, no information about HEV-68 is available for children yet. This study aimed to investigate the presence of HEV-68 in mainland China between 2009 and 201 2 and to explore the migration events of HEV-68 across the world. Among 1565 samples tested from children, 41 (2.6 %) were positive for HEV and 223 (14.3%) for human rhinovirus (HRV). Seven (17.1 %) of 41 HEVs were HEV-68. Two HEV-68- and five HRV-positive samples were detected in 585 adult samples. HEV-68 is the predominant type of enterovirus in children with acute respiratory tract infection (ARTI), followed by HEV-71 and coxsackievirus A6. Three HEV-68-infected children presented with severe pneumonia and one presented with a severe asthma attack. The viruses were attributed to two novel distinct sublineages of HEV-68 based on phylogenetic analysis of partial VP1 gene sequences. Migration events analysis showed that the USA and the Netherlands were possible geographical sources of HEV-68, from where three strains migrated to China. In conclusion, HEV-68 may play a predominant role among the enteroviruses associated with ARTI in children. Additional surveillance is needed to clarify the reason why HEV-68 causes such a wide spectrum of disease, from asymptomatic to severe respiratory disease and even death.

语种: 英语
所属项目编号: 2013ZX10004202-002 ; 81222037
项目资助者: China MEGA-Project on Infectious Disease Prevention ; National Natural Science Fund for Young Scholars
WOS记录号: WOS:000338478500009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55759
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Peking Univ, Sch Publ Hlth, Beijing 100191, Peoples R China
2.Beijing Inst Microbiol & Epidemiol, State Key Lab Pathogen & Biosecur, Beijing 100071, Peoples R China
3.Chongqing Med Univ, Childrens Hosp, Chongqing 400014, Peoples R China
4.Shandong Univ, Dept Epidemiol & Hlth Stat, Jinan 250012, Peoples R China

Recommended Citation:
Lu, Qing-Bin,Wo, Ying,Wang, Hong-Yu,et al. Detection of enterovirus 68 as one of the commonest types of enterovirus found in patients with acute respiratory tract infection in China[J]. JOURNAL OF MEDICAL MICROBIOLOGY,2014,63:408-414.
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