IR@PKUHSC  > 北京大学口腔医学院
学科主题口腔医学
Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice
Jiang Qing-song3,4; Liang Zi-liang1,2; Wu Min-jie5,6; Feng Lin5,6; Liu Li-li1,2; Zhang Jian-jun1,2
关键词Molarless Learning And Memory Water Maze Brain-derived Neurotrophic Factor Trkb
刊名CHINESE MEDICAL JOURNAL
2011-05-20
DOI10.3760/cma.j.issn.0366-6999.2011.10.019
124期:10页:1540-1544
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]REGION
英文摘要

Background The molarless condition has been reported to compromise learning and memory functions. However, it remains unclear how the molarless condition directly affects the central nervous system, and the functional consequences on the brain cortex and hippocampus have not been described in detail. The aim of this study was to find the molecular mechanism related with learning and memory deficit after a bilateral molarless condition having been surgically induced in senescence-accelerated mice/prone8 (SAMP8) mice, which may ultimately provide an experimental basis for clinical prevention of senile dementia.

Methods Mice were either sham-operated or subjected to complete molar removal. The animals′ body weights were monitored every day. Learning ability and memory were measured in a water maze test at the end of the 1st, 2nd, and 3rd months after surgery. As soon as significantly prolonged escape latency in the molarless group was detected, the locomotor activity was examined in an open field test. Subsequently, the animals were decapitated and the cortex and hippocampus were dissected for Western blotting to measure the expression levels of brain-derived neurotrophic factor (BDNF) and the tropomyosin related kinase B (TrkB), the high affinity receptor of BDNF.

Results Slightly lower weights were consistently observed in the molarless group, but there was no significant difference in weights between the two groups (P > 0.05). Compared with the sham group, the molarless group exhibited lengthened escape latency in the water maze test three months after surgery, whereas no difference in locomotor activity was observed. Meanwhile, in the cortex and hippocampus, BDNF levels were significantly decreased in the molarless group (P < 0.05); but the expression of its receptor, TrkB, was not significantly affected.

Conclusion These results suggested that the molarless condition impaired learning and memory abilities in SAMP8 mice three months after teeth extraction, and this effect was accompanied by significantly reduced BDNF expression in the cortex and hippocampus. Chin Med J 2011;124(10):1540-1544

语种英语
WOS记录号WOS:000291176100019
项目编号30801311 ; 2008B60 ; 7073091 ; 2007CB507400 ; 2009ZX09301-003
资助机构National Natural Science Foundation of China ; Beijing NOVA ; Beijing Natural Science Foundation ; National Basic Research Program (973 Program) ; National S&amp ; T Major Special Project on Major New Drug Innovation
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55767
专题北京大学口腔医学院
北京大学第二临床医学院_病理科
作者单位1.Peking Univ, Sch Stomatol, Beijing 100081, Peoples R China
2.Peking Univ, Hosp Stomatol, Beijing 100081, Peoples R China
3.Chinese Acad Med Sci, Dept Pharmacol, Inst Mat Med, Beijing 100050, Peoples R China
4.Peking Union Med Coll, Beijing 100050, Peoples R China
5.Chinese Acad Med Sci, Dept Prosthodont, Beijing Stomatol Hosp, Beijing 100050, Peoples R China
6.Chinese Acad Med Sci, Sch Stomatol, Beijing 100050, Peoples R China
推荐引用方式
GB/T 7714
Jiang Qing-song,Liang Zi-liang,Wu Min-jie,et al. Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice[J]. CHINESE MEDICAL JOURNAL,2011,124(10):1540-1544.
APA Jiang Qing-song,Liang Zi-liang,Wu Min-jie,Feng Lin,Liu Li-li,&Zhang Jian-jun.(2011).Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice.CHINESE MEDICAL JOURNAL,124(10),1540-1544.
MLA Jiang Qing-song,et al."Reduced brain-derived neurotrophic factor expression in cortex and hippocampus involved in the learning and memory deficit in molarless SAMP8 mice".CHINESE MEDICAL JOURNAL 124.10(2011):1540-1544.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Jiang Qing-song]的文章
[Liang Zi-liang]的文章
[Wu Min-jie]的文章
百度学术
百度学术中相似的文章
[Jiang Qing-song]的文章
[Liang Zi-liang]的文章
[Wu Min-jie]的文章
必应学术
必应学术中相似的文章
[Jiang Qing-song]的文章
[Liang Zi-liang]的文章
[Wu Min-jie]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。