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学科主题: 公共卫生
题名:
Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer
作者: Shen, Jing1,2; Wang, Run-Tian3; Xu, Yao-Chu2; Wang, Li-Wei4; Wang, Xin-Ru2
关键词: Interaction models ; CYP1A1 ; GSTM1 ; Tobacco smoking ; Intestinal gastric cancer
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2005-10-14
卷: 11, 期:38, 页:6056-6060
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
英文摘要:

AIM: To explore the interaction models of the cytochrome P-450 (CYP) 1A1 Val variant and glutathione S-transferase (GST) M1 null polymorphisms with tobacco smoking in the occurrence of intestinal gastric cancer.

METHODS: A community-based case-control study was conducted in Yangzhong. Subjects included 114 intestinal types of gastric cancer with endoscopic and pathological diagnosis during January 1997 and December 1998, and 693 controls selected from their spouse, siblings or siblings-in-law who had no history of digestive system cancer. Logistic regression was used to estimate the interaction models.

RESULTS: The frequency of the CYP1A1 Val variant allele in cases did not differ from that in controls. The OR of GSTM1 null genotype was 2.0 (95% confidence interval [95% CI]: 1.2-3.1, P<0.01). It showed a significant type 2 form of interaction model when both CYP1A1 Val variant allele and former tobacco smoking existed (i.e., among the multiplicative effects, the disease risk is increased by the tobacco exposure alone but not by the CYP1A1 variant alone). The interaction index gamma was 2.8, and OReg (95% CI) was 5.0 (1.9-13.4). GSTM1 null genotype and former tobacco smoking were significant in a type 4 interaction model (i.e., the disease risk is increased by GSTM1 null genotype or tobacco exposure alone among the multiplicative effects). The interaction index gamma and OReg (95% CI) were 3.4 and 8.4 (3.4-20.9), respectively.

CONCLUSION: Different interaction models of CYP1A1 Val variant allele and GSTM1 null genotype with tobacco smoking will contribute to understanding carcinogenic mechanism, but there is a need to further investigate in larger scale studies. (C) 2005 The WJG Press and Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 30170827 ; 30070671
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000208331000027
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内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55768
Appears in Collections:北京大学公共卫生学院_期刊论文

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作者单位: 1.Columbia Univ, Mailman Sch Publ Hlth, Dept Environm Hlth Sci, New York, NY 10032 USA
2.Nanjing Med Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Nanjing 210029, Jiangsu, Peoples R China
3.Peking Univ, Dept Epidemiol & Biostat, Sch Publ Hlth, Beijing 100083, Peoples R China
4.Yang Zhong City Municipal Hosp, Yang Zhong Canc Res Inst, Yang Zhong 212200, Peoples R China

Recommended Citation:
Shen, Jing,Wang, Run-Tian,Xu, Yao-Chu,et al. Interaction models of CYP1A1, GSTM1 polymorphisms and tobacco smoking in intestinal gastric cancer[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2005,11(38):6056-6060.
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