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学科主题临床医学
Renal involvement in a large cohort of Chinese patients with Castleman disease
Xu, Damin1,2; Lv, Jicheng1,2; Dong, Yujun3; Wang, Suxia1,2; Su, Tao1,2; Zhou, Fude1,2; Zou, Wanzhong1,2; Zhao, Minghui1,2; Zhang, Hong1,2
关键词Castleman&Prime s Disease Cohort Study Kidney Disease
刊名NEPHROLOGY DIALYSIS TRANSPLANTATION
2012-10-01
DOI10.1093/ndt/gfr245
suppl.3页:119-125
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Transplantation ; Urology & Nephrology
研究领域[WOS]Transplantation ; Urology & Nephrology
关键词[WOS]LYMPH-NODE HYPERPLASIA ; SYSTEMIC LYMPHOPROLIFERATIVE DISORDER ; MORPHOLOGIC FEATURES
英文摘要

Background. The association of kidney disease with Castleman disease (CD) is uncommon. To date, most studies have been based on single-case reports. Here, we describe renal involvement in CD in a large Chinese cohort.

Methods. Seventy-six CD patients were identified in one clinical center. Clinical and pathological characteristics of patients with renal involvement were described, which were also compared with cases identified through a systematic literature review.

Results. Nineteen patients (25%) exhibited renal involvement. Patients with multicentric clinical type (59 versus 0%) or plasma cell (PC)/mixed cellularity histological variant (61.5 versus 6%) were more likely to have renal involvement (P < 0.001). Proteinuria (with 7/19 reaching nephrotic range) and acute renal failure (12/19, 63%) were the main clinical presentations. Kidney biopsy revealed various glomerular diseases (10/11) and interstitial nephritis (1/11), while with ′thrombotic microangiopathy-like′ lesions were the most common pathological characteristics (6/11, 55%). This contrasted significantly with the literature in which amyloidosis was the most reported. Renal outcomes responded well to chemotherapy. Nine (9/12, 75%) patients with acute renal failure recovered completely, one recovered partially. Overall, only three (3/19, 16%) patients progressed to end-stage kidney disease. Renal involvement did not influence survival rate (log-rank test, P = 0.73) in the follow-up.

Conclusions. CD with multicentric type and PC or mixed cellularity variant are often associated with renal complications. Thrombotic microangiopathy-like lesions are the most common pathological characteristics. Chemotherapy can reverse kidney damage in most cases.

语种英语
WOS记录号WOS:000310628900019
项目编号30825021 ; 200802052
资助机构NSFC ; Foundation of Ministry of Health of China
引用统计
被引频次:19[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55771
专题北京大学第一临床医学院_肾脏内科
北京大学基础医学院
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_血液内科
作者单位1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
2.Peking Univ, Hosp 1, Inst Nephrol, Renal Div,Dept Med, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Xu, Damin,Lv, Jicheng,Dong, Yujun,et al. Renal involvement in a large cohort of Chinese patients with Castleman disease[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,suppl.3:119-125.
APA Xu, Damin.,Lv, Jicheng.,Dong, Yujun.,Wang, Suxia.,Su, Tao.,...&Zhang, Hong.(2012).Renal involvement in a large cohort of Chinese patients with Castleman disease.NEPHROLOGY DIALYSIS TRANSPLANTATION,suppl.3,119-125.
MLA Xu, Damin,et al."Renal involvement in a large cohort of Chinese patients with Castleman disease".NEPHROLOGY DIALYSIS TRANSPLANTATION suppl.3(2012):119-125.
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