|Renal involvement in a large cohort of Chinese patients with Castleman disease|
|Xu, Damin1,2; Lv, Jicheng1,2; Dong, Yujun3; Wang, Suxia1,2; Su, Tao1,2; Zhou, Fude1,2; Zou, Wanzhong1,2; Zhao, Minghui1,2; Zhang, Hong1,2|
|关键词||Castleman&Prime s Disease Cohort Study Kidney Disease|
|刊名||NEPHROLOGY DIALYSIS TRANSPLANTATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Transplantation ; Urology & Nephrology|
|研究领域[WOS]||Transplantation ; Urology & Nephrology|
|关键词[WOS]||LYMPH-NODE HYPERPLASIA ; SYSTEMIC LYMPHOPROLIFERATIVE DISORDER ; MORPHOLOGIC FEATURES|
Background. The association of kidney disease with Castleman disease (CD) is uncommon. To date, most studies have been based on single-case reports. Here, we describe renal involvement in CD in a large Chinese cohort.
Methods. Seventy-six CD patients were identified in one clinical center. Clinical and pathological characteristics of patients with renal involvement were described, which were also compared with cases identified through a systematic literature review.
Results. Nineteen patients (25%) exhibited renal involvement. Patients with multicentric clinical type (59 versus 0%) or plasma cell (PC)/mixed cellularity histological variant (61.5 versus 6%) were more likely to have renal involvement (P < 0.001). Proteinuria (with 7/19 reaching nephrotic range) and acute renal failure (12/19, 63%) were the main clinical presentations. Kidney biopsy revealed various glomerular diseases (10/11) and interstitial nephritis (1/11), while with ′thrombotic microangiopathy-like′ lesions were the most common pathological characteristics (6/11, 55%). This contrasted significantly with the literature in which amyloidosis was the most reported. Renal outcomes responded well to chemotherapy. Nine (9/12, 75%) patients with acute renal failure recovered completely, one recovered partially. Overall, only three (3/19, 16%) patients progressed to end-stage kidney disease. Renal involvement did not influence survival rate (log-rank test, P = 0.73) in the follow-up.
Conclusions. CD with multicentric type and PC or mixed cellularity variant are often associated with renal complications. Thrombotic microangiopathy-like lesions are the most common pathological characteristics. Chemotherapy can reverse kidney damage in most cases.
|项目编号||30825021 ; 200802052|
|资助机构||NSFC ; Foundation of Ministry of Health of China|
|作者单位||1.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China|
2.Peking Univ, Hosp 1, Inst Nephrol, Renal Div,Dept Med, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Hematol, Beijing 100871, Peoples R China
|Xu, Damin,Lv, Jicheng,Dong, Yujun,et al. Renal involvement in a large cohort of Chinese patients with Castleman disease[J]. NEPHROLOGY DIALYSIS TRANSPLANTATION,2012,suppl.3:119-125.|
|APA||Xu, Damin.,Lv, Jicheng.,Dong, Yujun.,Wang, Suxia.,Su, Tao.,...&Zhang, Hong.(2012).Renal involvement in a large cohort of Chinese patients with Castleman disease.NEPHROLOGY DIALYSIS TRANSPLANTATION,suppl.3,119-125.|
|MLA||Xu, Damin,et al."Renal involvement in a large cohort of Chinese patients with Castleman disease".NEPHROLOGY DIALYSIS TRANSPLANTATION suppl.3(2012):119-125.|
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