IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)
Wang, Yang1; Sheng, Shijie2; Zhang, Jianzhi1; Dzinic, Sijana2; Li, Shaolei1; Fang, Fang1; Wu, Nan1; Zheng, Qingfeng1; Yang, Yue1
刊名PLOS ONE
2013-05-22
DOI10.1371/journal.pone.0063581
8期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]TUMOR-SUPPRESSIVE MASPIN ; INVASIVE BREAST-CANCER ; PLASMINOGEN-ACTIVATOR ; GENETIC POLYMORPHISMS ; CLINICAL-IMPLICATIONS ; NUCLEAR-LOCALIZATION ; VEGF-A ; INHIBITION ; METASTASIS ; GROWTH
英文摘要

Tumor suppressor maspin is a differentially regulated gene in the progression of many types of cancer. While the biological function of maspin in blocking tumor invasion and metastasis is consistent with the loss of maspin expression at the late stage of tumor progression, the differential expression and the biological significance of maspin in early stage of tumor progression appear to be complex and remain to be elucidated. In the current study, we examined the expression of maspin in 84 esophageal squamous cell carcinoma (ESCC) cases (stages I-III) and 55 non-tumor adjacent esophageal tissue specimens by immunohistochemical (IHC) staining. The correlation of maspin with clinicopathological parameters was analyzed. Compared to normal esophageal squamous tissue where 80% (47/55) of the cases expressed maspin at a low to moderate level, all ESCC specimens (100% (84/84)) were positive for maspin expression at a moderate to high level. ESCC with low or moderate maspin expression had significantly shorter postoperative survival rates compared to those that had high maspin expression (p<0.001). Since the correlation of maspin with ESCC histology and the correlation of maspin with ESCC prognosis seem to be at odds, we further investigated the biological function of maspin in ESCC using the established ESCC cell lines. The expression of maspin in five human esophageal squamous cancer cell lines (T12, E450, KYSE150, EC109, and KYSE510) was examined by the Western blot. ESCC cell line KYSE510 that did not express maspin and was stably transfected by maspin cDNA or an empty vector. The resulting transfected cells were characterized in vitro. Maspin expression significantly inhibited cell proliferation, motility and matrigel invasion. Taken together, our data suggest that the transient up-regulation of maspin in the early development of ESCC may be a defense mechanism against further transition towards more malignant phenotypes, ultimately slowing down ESCC tumor progression.

语种英语
WOS记录号WOS:000320362700036
项目编号CA15431 ; CA084176
资助机构NIH ; Ruth Sager Memorial Fund
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55775
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_胸部肿瘤外二科
作者单位1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Beijing 100871, Peoples R China
2.Wayne State Univ, Sch Med, Dept Pathol, Barbara Ann Karmanos Canc Inst,Tumor & Microenvir, Detroit, MI 48201 USA
推荐引用方式
GB/T 7714
Wang, Yang,Sheng, Shijie,Zhang, Jianzhi,et al. Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)[J]. PLOS ONE,2013,8(5).
APA Wang, Yang.,Sheng, Shijie.,Zhang, Jianzhi.,Dzinic, Sijana.,Li, Shaolei.,...&Yang, Yue.(2013).Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC).PLOS ONE,8(5).
MLA Wang, Yang,et al."Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)".PLOS ONE 8.5(2013).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yang]的文章
[Sheng, Shijie]的文章
[Zhang, Jianzhi]的文章
百度学术
百度学术中相似的文章
[Wang, Yang]的文章
[Sheng, Shijie]的文章
[Zhang, Jianzhi]的文章
必应学术
必应学术中相似的文章
[Wang, Yang]的文章
[Sheng, Shijie]的文章
[Zhang, Jianzhi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。