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学科主题: 临床医学
题名:
Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)
作者: Wang, Yang1; Sheng, Shijie2; Zhang, Jianzhi1; Dzinic, Sijana2; Li, Shaolei1; Fang, Fang1; Wu, Nan1; Zheng, Qingfeng1; Yang, Yue1
刊名: PLOS ONE
发表日期: 2013-05-22
DOI: 10.1371/journal.pone.0063581
卷: 8, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: TUMOR-SUPPRESSIVE MASPIN ; INVASIVE BREAST-CANCER ; PLASMINOGEN-ACTIVATOR ; GENETIC POLYMORPHISMS ; CLINICAL-IMPLICATIONS ; NUCLEAR-LOCALIZATION ; VEGF-A ; INHIBITION ; METASTASIS ; GROWTH
英文摘要:

Tumor suppressor maspin is a differentially regulated gene in the progression of many types of cancer. While the biological function of maspin in blocking tumor invasion and metastasis is consistent with the loss of maspin expression at the late stage of tumor progression, the differential expression and the biological significance of maspin in early stage of tumor progression appear to be complex and remain to be elucidated. In the current study, we examined the expression of maspin in 84 esophageal squamous cell carcinoma (ESCC) cases (stages I-III) and 55 non-tumor adjacent esophageal tissue specimens by immunohistochemical (IHC) staining. The correlation of maspin with clinicopathological parameters was analyzed. Compared to normal esophageal squamous tissue where 80% (47/55) of the cases expressed maspin at a low to moderate level, all ESCC specimens (100% (84/84)) were positive for maspin expression at a moderate to high level. ESCC with low or moderate maspin expression had significantly shorter postoperative survival rates compared to those that had high maspin expression (p<0.001). Since the correlation of maspin with ESCC histology and the correlation of maspin with ESCC prognosis seem to be at odds, we further investigated the biological function of maspin in ESCC using the established ESCC cell lines. The expression of maspin in five human esophageal squamous cancer cell lines (T12, E450, KYSE150, EC109, and KYSE510) was examined by the Western blot. ESCC cell line KYSE510 that did not express maspin and was stably transfected by maspin cDNA or an empty vector. The resulting transfected cells were characterized in vitro. Maspin expression significantly inhibited cell proliferation, motility and matrigel invasion. Taken together, our data suggest that the transient up-regulation of maspin in the early development of ESCC may be a defense mechanism against further transition towards more malignant phenotypes, ultimately slowing down ESCC tumor progression.

语种: 英语
所属项目编号: CA15431 ; CA084176
项目资助者: NIH ; Ruth Sager Memorial Fund
WOS记录号: WOS:000320362700036
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55775
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res Minist Educ, Beijing 100871, Peoples R China
2.Wayne State Univ, Sch Med, Dept Pathol, Barbara Ann Karmanos Canc Inst,Tumor & Microenvir, Detroit, MI 48201 USA

Recommended Citation:
Wang, Yang,Sheng, Shijie,Zhang, Jianzhi,et al. Elevated Maspin Expression Is Associated with Better Overall Survival in Esophageal Squamous Cell Carcinoma (ESCC)[J]. PLOS ONE,2013,8(5).
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