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学科主题基础医学
Primary peritoneal malignant mixed Mullerian tumors - A clinicopathologic, immunohistochemical, and genetic study
Shen, DH; Khoo, US; Xue, WC; Ngan, HYS; Wang, JL; Liu, VWS; Chan, YK; Cheung, ANY
关键词Peritoneum Malignant Mixed Mullerian Tumors (Mmmts) Hormone Receptors Brca-1 Mutation Clonality
刊名CANCER
2001-03-01
91期:5页:1052-1060
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]PAPILLARY SEROUS CARCINOMA ; MESODERMAL TUMOR ; BRCA1 GENE ; FEMALE PERITONEUM ; SOMATIC MUTATIONS ; OVARIAN-CANCER ; ESTROGEN ; RECEPTOR ; SARCOMA ; TRACT
英文摘要

BACKGROUND. Primary peritoneal malignant mixed Mullerian tumors (MMMTs) are rarely reported in the literature.

METHODS, The clinical, pathologic, and immunohistochemical features of five cases of MMMT of female peritoneum were analyzed. The tumors were also investigated for expression of hormone receptors, specific BRCA-1 mutations, and clonality.

RESULTS. The patients′ ages ranged from 33 to 67 years. They presented with abdominal pain or mass. One case of peritoneal MMMT was associated with a synchronous endometrial carcinoma whereas another case was detected 2 years after the diagnosis of a primary adenocarcinoma of the fallopian tube. One patient died 1 month after diagnosis whereas 2 patients died with disease within 1 year. Both carcinomatous and sarcomatous elements are present in all the tumors. Squamous differentiation was noted in two cases. Heterologous elements, including chondroid, rhabodomyoblastic, and osteoid differentiation were detected in all tumors. Immunohistochemical studies confirm the biphasic differentiation with variable demonstration of neural and smooth muscle differentiation. All five MMMTs were negative for estrogen and progestogen receptors although the related endometrial and tubal carcinomas were positive. Heteroduplex analysis used to screen for specific BRCA-1 mutations were negative in all five MMMTs. Clonality study of the two MMMTs found in association with endometrial carcinoma and tubal carcinoma was inconclusive.

CONCLUSIONS, Our study confirmed that primary peritoneal MMMTs were aggressive tumors with poor prognosis. The presence of synchronous or metachronous genital carcinomas suggests multifocal tumorigenesis from tissue of same embryologic origin. The lack of hormone receptor in these tumors indicates deviation from hormonal control. Specific BRCA-1 mutations found in ovarian carcinoma in Chinese patients could not be detected in our series. (C) 2001 American Cancer Society.

语种英语
WOS记录号WOS:000167348200021
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55778
专题基础医学院_病理学系
作者单位1.Beijing Med Univ, Dept Pathol, Beijing 100083, Peoples R China
2.Univ Hong Kong, Queen Mary Hosp, Dept Pathol, Hong Kong, Hong Kong, Peoples R China
3.Univ Hong Kong, Queen Mary Hosp, Dept Obstet & Gynecol, Hong Kong, Hong Kong, Peoples R China
4.Beijing Med Univ, Peoples Hosp, Dept Gynecol, Beijing 100083, Peoples R China
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Shen, DH,Khoo, US,Xue, WC,et al. Primary peritoneal malignant mixed Mullerian tumors - A clinicopathologic, immunohistochemical, and genetic study[J]. CANCER,2001,91(5):1052-1060.
APA Shen, DH.,Khoo, US.,Xue, WC.,Ngan, HYS.,Wang, JL.,...&Cheung, ANY.(2001).Primary peritoneal malignant mixed Mullerian tumors - A clinicopathologic, immunohistochemical, and genetic study.CANCER,91(5),1052-1060.
MLA Shen, DH,et al."Primary peritoneal malignant mixed Mullerian tumors - A clinicopathologic, immunohistochemical, and genetic study".CANCER 91.5(2001):1052-1060.
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