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学科主题: 药学
题名:
Cannabinoid Receptor Activation Disrupts the Internal Structure of Hippocampal Sharp Wave-Ripple Complexes
作者: Sun, Yi1,2; Norimoto, Hiroaki1; Pu, Xiao-Ping2; Matsuki, Norio1; Ikegaya, Yuji1
关键词: hippocampus ; local field potential ; memory consolidation ; endocannabinoid ; type 1 cannabinoid (CBI) receptor
刊名: JOURNAL OF PHARMACOLOGICAL SCIENCES
发表日期: 2012-02-01
DOI: 10.1254/jphs.11199FP
卷: 118, 期:2, 页:288-294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: IMPAIRS SPATIAL MEMORY ; LONG-TERM POTENTIATION ; IN-VITRO ; CALCIUM-CHANNELS ; NEURONS ; RATS ; OSCILLATIONS ; NETWORKS ; SLICES ; CELLS
英文摘要:

Cannabinoid agonists impair hippocampus-dependent learning and memory. Using mouse hippocampal slice preparations, we examined the effect of anandamide, an endogenous cannabinoid, on sharp wave ripple (SW-R) complexes, which are believed to mediate memory consolidation during slow-wave sleep or behavioral immobility. Anandamide reduced the frequency of SW-Rs recorded from the CA3 region, and this effect was abolished by AM251, a cannabinoid CBI receptor antagonist. We further addressed the action of anandamide using a functional multineuron calcium imaging technique. Anandamide reduced the firing rate of hippocampal neurons as well as disrupted the temporal coordination of their firings during SW-R.

语种: 英语
所属项目编号: LS023
项目资助者: Funding Program for Next Generation World-Leading Researchers ; China Scholarship Council
WOS记录号: WOS:000300915400021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55781
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Univ Tokyo, Grad Sch Pharmaceut Sci, Lab Chem Pharmacol, Tokyo 1130033, Japan
2.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China

Recommended Citation:
Sun, Yi,Norimoto, Hiroaki,Pu, Xiao-Ping,et al. Cannabinoid Receptor Activation Disrupts the Internal Structure of Hippocampal Sharp Wave-Ripple Complexes[J]. JOURNAL OF PHARMACOLOGICAL SCIENCES,2012,118(2):288-294.
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