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CLINICAL CHARACTERISTICS AND OUTCOMES OF PERITONEAL DIALYSIS-RELATED PERITONITIS WITH DIFFERENT TRENDS OF CHANGE IN EFFLUENT WHITE CELL COUNT: A LONGITUDINAL STUDY
Xu, Rong1; Chen, Yuan1; Luo, Suping1; Xu, Ying1; Zheng, Bo5; Zheng, Yingdong6; Dong, Jie1
关键词Peritonitis Peritoneal Effluent Outcomes
刊名PERITONEAL DIALYSIS INTERNATIONAL
2013-07-01
DOI10.3747/pdi.2012.00163
33期:4页:436-444
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
资助者Beijing Science and Technology Committee ; Scientific Research Foundation for Returned Scholars from Peking University ; Research Foundation for New Century Excellent Talents in University ; Ketosteril Research Award from Fresenius Kabi Deutschland ; Baxter Corporation, PR China ; Beijing Science and Technology Committee ; Scientific Research Foundation for Returned Scholars from Peking University ; Research Foundation for New Century Excellent Talents in University ; Ketosteril Research Award from Fresenius Kabi Deutschland ; Baxter Corporation, PR China
研究领域[WOS]Urology & Nephrology
关键词[WOS]INFECTIONS RECOMMENDATIONS ; BACTERIAL PERITONITIS ; LIPOTEICHOIC ACID ; RELEASE ; NEUTROPHILS ; SEPSIS ; UPDATE
英文摘要

Background: Effluent white cell count (WCC) is among the important prognostic factors for peritonitis outcome, but its trend has never been studied. We aimed to explore the clinical characteristics and outcomes of peritonitis episodes having different trends in effluent WCC change in the first 5 days.

Methods: For each peritonitis episode, we examined the patient′s demographic and biochemical data, serial effluent WCC, and organisms cultured. Peritonitis-associated death and transfer to hemodialysis were defined as treatment failure.

Results: Based on the trend of effluent WCC in the first 5 days, we divided 190 peritonitis episodes into group A (WCC persistently declined), group B (WCC declined after a transient increase), group C (WCC increased after a transient decline), and group D (WCC persistently increased). In group A, peritonitis was caused mostly by gram-positive organisms, and effluent WCC declined the most quickly, leading to a good prognosis. Although the elevation of effluent WCC was prolonged in group B, and the infections were, compared with those in group A, more often caused by gram-negative organisms, outcomes were not worse. In group C, the effluent WCC was more likely to be higher than 100/mu L on day 5, and the infection was, compared with those in groups A and B, less likely to be caused by gram-positive organisms. Accordingly, membership in group C independently predicted the worst outcome of peritonitis even adjusted for age, sex, and causative organism.

Conclusions: Different trends of change in effluent WCC during the early stage of peritonitis represent different clinical patterns and outcomes. Further investigation for optimizing outcomes is required.

语种英语
资助者Beijing Science and Technology Committee ; Scientific Research Foundation for Returned Scholars from Peking University ; Research Foundation for New Century Excellent Talents in University ; Ketosteril Research Award from Fresenius Kabi Deutschland ; Baxter Corporation, PR China ; Beijing Science and Technology Committee ; Scientific Research Foundation for Returned Scholars from Peking University ; Research Foundation for New Century Excellent Talents in University ; Ketosteril Research Award from Fresenius Kabi Deutschland ; Baxter Corporation, PR China
WOS记录号WOS:000321619800017
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55782
专题北京大学第一临床医学院_肾脏内科
作者单位1.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
2.Minist Hlth China, Key Lab Renal Dis, Beijing, Peoples R China
3.Minist Educ China, Key Lab Renal Dis, Beijing, Peoples R China
4.Peking Univ, Hosp 1, Div Renal, Dept Med, Beijing 100034, Peoples R China
5.Peking Univ, Affiliated Hosp 1, Div Renal, Inst Clin Pharmacol, Beijing 100034, Peoples R China
6.Peking Univ, Sch Publ Hlth, Beijing 100034, Peoples R China
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Xu, Rong,Chen, Yuan,Luo, Suping,et al. CLINICAL CHARACTERISTICS AND OUTCOMES OF PERITONEAL DIALYSIS-RELATED PERITONITIS WITH DIFFERENT TRENDS OF CHANGE IN EFFLUENT WHITE CELL COUNT: A LONGITUDINAL STUDY[J]. PERITONEAL DIALYSIS INTERNATIONAL,2013,33(4):436-444.
APA Xu, Rong.,Chen, Yuan.,Luo, Suping.,Xu, Ying.,Zheng, Bo.,...&Dong, Jie.(2013).CLINICAL CHARACTERISTICS AND OUTCOMES OF PERITONEAL DIALYSIS-RELATED PERITONITIS WITH DIFFERENT TRENDS OF CHANGE IN EFFLUENT WHITE CELL COUNT: A LONGITUDINAL STUDY.PERITONEAL DIALYSIS INTERNATIONAL,33(4),436-444.
MLA Xu, Rong,et al."CLINICAL CHARACTERISTICS AND OUTCOMES OF PERITONEAL DIALYSIS-RELATED PERITONITIS WITH DIFFERENT TRENDS OF CHANGE IN EFFLUENT WHITE CELL COUNT: A LONGITUDINAL STUDY".PERITONEAL DIALYSIS INTERNATIONAL 33.4(2013):436-444.
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