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学科主题: 临床医学
题名:
HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation
作者: Du, Jinwei; Liu, Jing; Gu, Jiangying; Zhu, Ping
关键词: graft-versus-host disease ; human leukocyte antigen ; cytomegalovirus ; hematopoietic stem cell transplantation
刊名: BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
发表日期: 2007-12-01
DOI: 10.1016/j.bbmt.2007.09.003
卷: 13, 期:12, 页:1417-1421
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Hematology ; Immunology ; Transplantation
研究领域[WOS]: Hematology ; Immunology ; Transplantation
关键词[WOS]: CORD BLOOD TRANSPLANTATION ; VERSUS-HOST-DISEASE ; MARROW-TRANSPLANTATION ; HLA-B ; UNRELATED DONORS ; ADULT PATIENTS ; CMV INFECTION ; RISK-FACTORS ; RECIPIENTS ; GRAFT
英文摘要:

Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, we have little information on the clinical association of various human leukocyte antigen (HLA) alleles with CMV infection. We reviewed medical records of 60 patients who underwent allo-HSCT. The effect of the 7 most frequent HLA alleles on the incidence of CMV infection and disease was analyzed, including HLA-A*02, A*11, A*24, B*13, B*40(60), DRB1*15, and DRB1*09. All the patients were monitored for CMV infection at least once weekly within 3 months. CMV infection was found in 38 (63.3%) patients on a median of day 36 (range: 16-89). Diagnosis of CMV disease was established in 6 (10.0%) patients, comprising pneumonia (n = 2), enterocolitis (n = 2), and hemorrhagic cystitis (n = 2). CMV disease was successfully treated using ganciclovir or foscarnet combined with immune globulins in 4 patients. The other 2 patients died without improvement of CMV disease. In multivariate analysis, grade II-IV acute graft-versus-host disease (aGVHD), CMV seronegative donors, and HLA-DRB1*09 were associated with increased incidence of CMW infection and disease after allo-HSCT. We suggest that more cautions should be taken to prevent CNIV infection in patients with HLA-DRB1*09 after allo-HSCT. (c) 2007 American Society for Blood and Marrow Transplantation.

语种: 英语
WOS记录号: WOS:000251495900002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55784
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: Peking Univ, First Hosp, Dept Hematol, Beijing 100034, Peoples R China

Recommended Citation:
Du, Jinwei,Liu, Jing,Gu, Jiangying,et al. HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2007,13(12):1417-1421.
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