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HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation
Du, Jinwei; Liu, Jing; Gu, Jiangying; Zhu, Ping
关键词Graft-versus-host Disease Human Leukocyte Antigen Cytomegalovirus Hematopoietic Stem Cell Transplantation
刊名BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
2007-12-01
DOI10.1016/j.bbmt.2007.09.003
13期:12页:1417-1421
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Hematology ; Immunology ; Transplantation
研究领域[WOS]Hematology ; Immunology ; Transplantation
关键词[WOS]CORD BLOOD TRANSPLANTATION ; VERSUS-HOST-DISEASE ; MARROW-TRANSPLANTATION ; HLA-B ; UNRELATED DONORS ; ADULT PATIENTS ; CMV INFECTION ; RISK-FACTORS ; RECIPIENTS ; GRAFT
英文摘要

Cytomegalovirus (CMV) infection is a major complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT); however, we have little information on the clinical association of various human leukocyte antigen (HLA) alleles with CMV infection. We reviewed medical records of 60 patients who underwent allo-HSCT. The effect of the 7 most frequent HLA alleles on the incidence of CMV infection and disease was analyzed, including HLA-A*02, A*11, A*24, B*13, B*40(60), DRB1*15, and DRB1*09. All the patients were monitored for CMV infection at least once weekly within 3 months. CMV infection was found in 38 (63.3%) patients on a median of day 36 (range: 16-89). Diagnosis of CMV disease was established in 6 (10.0%) patients, comprising pneumonia (n = 2), enterocolitis (n = 2), and hemorrhagic cystitis (n = 2). CMV disease was successfully treated using ganciclovir or foscarnet combined with immune globulins in 4 patients. The other 2 patients died without improvement of CMV disease. In multivariate analysis, grade II-IV acute graft-versus-host disease (aGVHD), CMV seronegative donors, and HLA-DRB1*09 were associated with increased incidence of CMW infection and disease after allo-HSCT. We suggest that more cautions should be taken to prevent CNIV infection in patients with HLA-DRB1*09 after allo-HSCT. (c) 2007 American Society for Blood and Marrow Transplantation.

语种英语
WOS记录号WOS:000251495900002
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被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55784
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, First Hosp, Dept Hematol, Beijing 100034, Peoples R China
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GB/T 7714
Du, Jinwei,Liu, Jing,Gu, Jiangying,et al. HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation[J]. BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,2007,13(12):1417-1421.
APA Du, Jinwei,Liu, Jing,Gu, Jiangying,&Zhu, Ping.(2007).HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation.BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION,13(12),1417-1421.
MLA Du, Jinwei,et al."HLA-DRBI*09 is associated with increased incidence of cytomegalovirus infection and disease after allogeneic hematopoietic stem cell transplantation".BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION 13.12(2007):1417-1421.
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