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学科主题: 基础医学
题名:
Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice
作者: Chen, Juanjuan; Zhang, Lijie; Wen, Weigang; Hao, Jiaqing; Zeng, Pumei; Qian, Xiaoping; Zhang, Yu1; Yin, Yanhui
刊名: PLOS ONE
发表日期: 2012-10-11
DOI: 10.1371/journal.pone.0047219
卷: 7, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: REGULATORY T-CELLS ; TUMOR-INFILTRATING LYMPHOCYTES ; HUMAN HEPATOCELLULAR-CARCINOMA ; LARGE ESTABLISHED MELANOMA ; TESTIS ANTIGEN HCA587 ; DENDRITIC CELLS ; CANCER-PATIENTS ; MAGE-3 PROTEIN ; OVARIAN-CANCER ; IMMUNOTHERAPY
英文摘要:

HCA587 (also known as MAGE-C2) is a "cancer-testis" antigen highly expressed in a number of malignancies with unique immunological properties, making it a promising target for tumor immunotherapy. In this report, we demonstrated that HCA587 protein, when formulated with adjuvants CpG-containing oligodeoxynucleotides (CpG ODN) and ISCOM, was capable of inducing a potent cellular and humoral immune response as indicated by the presence of a large number of HCA587-specific, IFN-gamma-producing CD4(+) T cells and high levels of HCA587-specific antibodies. More importantly, vaccination with HCA587 conferred protection against challenge with HCA587-expressing B16 melanoma in prophylactic and therapeutic settings. In analysis of the mechanisms underlying the protective effect, we showed that the vaccination was followed by enhanced accumulation of tumor-infiltrating lymphocytes (TILs) with enrichment of conventional CD4(+) T cells but reduced representation of Treg cells. Further, the antitumor effect was largely abrogated in mice either depleted of CD4(+) T cells or deficient for IFN-gamma. These results indicate that HCA587 protein vaccine possesses evident antitumor activity in a mouse model and holds promise for treatment of human cancers.

语种: 英语
所属项目编号: 2006AA02Z486 ; 2011CB946100 ; 7071006
项目资助者: Ministry of Science and Technology ; Beijing Municipal Government Foundation for Natural Sciences
WOS记录号: WOS:000309807700068
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55785
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Dept Immunol,Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China

Recommended Citation:
Chen, Juanjuan,Zhang, Lijie,Wen, Weigang,et al. Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice[J]. PLOS ONE,2012,7(10).
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