IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice
Chen, Juanjuan; Zhang, Lijie; Wen, Weigang; Hao, Jiaqing; Zeng, Pumei; Qian, Xiaoping; Zhang, Yu1; Yin, Yanhui
刊名PLOS ONE
2012-10-11
DOI10.1371/journal.pone.0047219
7期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]REGULATORY T-CELLS ; TUMOR-INFILTRATING LYMPHOCYTES ; HUMAN HEPATOCELLULAR-CARCINOMA ; LARGE ESTABLISHED MELANOMA ; TESTIS ANTIGEN HCA587 ; DENDRITIC CELLS ; CANCER-PATIENTS ; MAGE-3 PROTEIN ; OVARIAN-CANCER ; IMMUNOTHERAPY
英文摘要

HCA587 (also known as MAGE-C2) is a "cancer-testis" antigen highly expressed in a number of malignancies with unique immunological properties, making it a promising target for tumor immunotherapy. In this report, we demonstrated that HCA587 protein, when formulated with adjuvants CpG-containing oligodeoxynucleotides (CpG ODN) and ISCOM, was capable of inducing a potent cellular and humoral immune response as indicated by the presence of a large number of HCA587-specific, IFN-gamma-producing CD4(+) T cells and high levels of HCA587-specific antibodies. More importantly, vaccination with HCA587 conferred protection against challenge with HCA587-expressing B16 melanoma in prophylactic and therapeutic settings. In analysis of the mechanisms underlying the protective effect, we showed that the vaccination was followed by enhanced accumulation of tumor-infiltrating lymphocytes (TILs) with enrichment of conventional CD4(+) T cells but reduced representation of Treg cells. Further, the antitumor effect was largely abrogated in mice either depleted of CD4(+) T cells or deficient for IFN-gamma. These results indicate that HCA587 protein vaccine possesses evident antitumor activity in a mouse model and holds promise for treatment of human cancers.

语种英语
WOS记录号WOS:000309807700068
项目编号2006AA02Z486 ; 2011CB946100 ; 7071006
资助机构Ministry of Science and Technology ; Beijing Municipal Government Foundation for Natural Sciences
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55785
专题北京大学基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Minist Hlth, Dept Immunol,Sch Basic Med Sci, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Hlth, Key Lab Med Immunol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Chen, Juanjuan,Zhang, Lijie,Wen, Weigang,et al. Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice[J]. PLOS ONE,2012,7(10).
APA Chen, Juanjuan.,Zhang, Lijie.,Wen, Weigang.,Hao, Jiaqing.,Zeng, Pumei.,...&Yin, Yanhui.(2012).Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice.PLOS ONE,7(10).
MLA Chen, Juanjuan,et al."Induction of HCA587-Specific Antitumor Immunity with HCA587 Protein Formulated with CpG and ISCOM in Mice".PLOS ONE 7.10(2012).
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
journal.pone.0047219(1601KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Juanjuan]的文章
[Zhang, Lijie]的文章
[Wen, Weigang]的文章
百度学术
百度学术中相似的文章
[Chen, Juanjuan]的文章
[Zhang, Lijie]的文章
[Wen, Weigang]的文章
必应学术
必应学术中相似的文章
[Chen, Juanjuan]的文章
[Zhang, Lijie]的文章
[Wen, Weigang]的文章
相关权益政策
暂无数据
收藏/分享
文件名: journal.pone.0047219.PDF
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。