北京大学医学 !E iv>
Advanced  
IR@PKUHSC  > 基础医学院  > 神经生物学系  > 期刊论文
学科主题: 基础医学
题名:
A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro
作者: Song, Yilin1; Lin, Nansen1,2; Liu, Chunxiu1; Jiang, Hong3,4; Xing, Guogang3,4; Cai, Xinxia1,2
关键词: Dual mode ; Microelectrode array (MEA) ; Neuroelectrical ; Neurochemical ; Neural spike ; Dopamine
刊名: BIOSENSORS & BIOELECTRONICS
发表日期: 2012-10-01
DOI: 10.1016/j.bios.2012.05.011
卷: 38, 期:1, 页:416-420
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
研究领域[WOS]: Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
关键词[WOS]: NEURONAL NETWORKS ; CULTURE ; STIMULATION ; ELECTRODES ; INVITRO ; SLICES ; CELLS
英文摘要:

The communication between neurons is inherently electrical and chemical in nature. In situ, simultaneous acquisition for the dual mode signals is important for neuroscience research. In this paper, the concept of dual mode neural microelectrode array (MEA) sensor was proposed, and a low cost thin film MEA chip for in vitro test was fabricated using standard lithography technology. The sensor incorporates arrayed microelectrodes, a counter electrode and a reference electrode on one glass slide, which is suitable for electrophysiological and electrochemical recording in vitro. Electrophysiological recordings were carried out on acute hippocampus slice. Local field potentials and three different spike firing patterns with the amplitude ranging from +/- 20 mu V to +/- 60 mu V were acquired by the arrayed microelectrodes. Electrochemical current response of the microelectrodes to calibrated dopamine solution was tested. A good linear relationship between the current and dopamine concentration was observed, with the detection sensitivity of 4671 mu A mM(-1) cm(-2) and a correlation coefficient of 0.986. The sensor is novel for its capability of detecting in vitro dual mode neural signals on one single chip. (C) 2012 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2011CB933202 ; 61027001 ; 61125105 ; 61002037 ; XDA06020101 ; Y2010015
项目资助者: Major National Scientific Research Plan ; NSFC ; Strategic Pilot Project for Science and Technology of CAS ; CAS Program
WOS记录号: WOS:000308455700066
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55787
Appears in Collections:基础医学院_神经生物学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro.pdf(3425KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Elect, State Key Lab Transducer Technol, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China

Recommended Citation:
Song, Yilin,Lin, Nansen,Liu, Chunxiu,et al. A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro[J]. BIOSENSORS & BIOELECTRONICS,2012,38(1):416-420.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Song, Yilin]'s Articles
[Lin, Nansen]'s Articles
[Liu, Chunxiu]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Song, Yilin]‘s Articles
[Lin, Nansen]‘s Articles
[Liu, Chunxiu]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace