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A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro
Song, Yilin1; Lin, Nansen1,2; Liu, Chunxiu1; Jiang, Hong3,4; Xing, Guogang3,4; Cai, Xinxia1,2
关键词Dual mode Microelectrode array (MEA) Neuroelectrical Neurochemical Neural spike Dopamine
刊名BIOSENSORS & BIOELECTRONICS
2012-10-01
DOI10.1016/j.bios.2012.05.011
38期:1页:416-420
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry, Analytical ; Electrochemistry ; Nanoscience & Nanotechnology
研究领域[WOS]Biophysics ; Biotechnology & Applied Microbiology ; Chemistry ; Electrochemistry ; Science & Technology - Other Topics
关键词[WOS]NEURONAL NETWORKS ; CULTURE ; STIMULATION ; ELECTRODES ; INVITRO ; SLICES ; CELLS
英文摘要

The communication between neurons is inherently electrical and chemical in nature. In situ, simultaneous acquisition for the dual mode signals is important for neuroscience research. In this paper, the concept of dual mode neural microelectrode array (MEA) sensor was proposed, and a low cost thin film MEA chip for in vitro test was fabricated using standard lithography technology. The sensor incorporates arrayed microelectrodes, a counter electrode and a reference electrode on one glass slide, which is suitable for electrophysiological and electrochemical recording in vitro. Electrophysiological recordings were carried out on acute hippocampus slice. Local field potentials and three different spike firing patterns with the amplitude ranging from +/- 20 mu V to +/- 60 mu V were acquired by the arrayed microelectrodes. Electrochemical current response of the microelectrodes to calibrated dopamine solution was tested. A good linear relationship between the current and dopamine concentration was observed, with the detection sensitivity of 4671 mu A mM(-1) cm(-2) and a correlation coefficient of 0.986. The sensor is novel for its capability of detecting in vitro dual mode neural signals on one single chip. (C) 2012 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000308455700066
项目编号2011CB933202 ; 61027001 ; 61125105 ; 61002037 ; XDA06020101 ; Y2010015
资助机构Major National Scientific Research Plan ; NSFC ; Strategic Pilot Project for Science and Technology of CAS ; CAS Program
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55787
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Neurosci Res Inst, Beijing 100191, Peoples R China
2.Peking Univ, Dept Neurobiol, Beijing 100191, Peoples R China
3.Chinese Acad Sci, Inst Elect, State Key Lab Transducer Technol, Beijing 100190, Peoples R China
4.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
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GB/T 7714
Song, Yilin,Lin, Nansen,Liu, Chunxiu,et al. A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro[J]. BIOSENSORS & BIOELECTRONICS,2012,38(1):416-420.
APA Song, Yilin,Lin, Nansen,Liu, Chunxiu,Jiang, Hong,Xing, Guogang,&Cai, Xinxia.(2012).A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro.BIOSENSORS & BIOELECTRONICS,38(1),416-420.
MLA Song, Yilin,et al."A novel dual mode microelectrode array for neuroelectrical and neurochemical recording in vitro".BIOSENSORS & BIOELECTRONICS 38.1(2012):416-420.
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