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学科主题: 临床医学
题名:
Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18
作者: Chen, Wen1,2; Zhang, Xun1; Molijn, Anco3; Jenkins, David4; Shi, Ju-Fang1; Quint, Wim3; Schmidt, Johannes E.5; Wang, Ping6; Liu, Yu-Ling7; Li, Lian-Kun8; Shi, Hong9; Liu, Ji-Hong10; Xie, Xing11; Niyazi, Mayinuer12; Yang, Pei13; Wei, Li-Hui14; Li, Long-Yu15; Li, Jie16; Liu, Jin-Feng17; Zhou, Qi18; Hong, Ying19; Li, Li20; Li, Qing21; Zhou, Hong-Lin22; Bian, Mei-Lu23; Chen, Jing24; Qiao, You-Lin1; Smith, Jennifer S.25
关键词: Human papillomavirus ; Cervical cancer ; High-grade squamous intraepithelial lesions ; Epidemiology ; China
刊名: CANCER CAUSES & CONTROL
发表日期: 2009-11-01
DOI: 10.1007/s10552-009-9422-z
卷: 20, 期:9, 页:1705-1713
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Public, Environmental & Occupational Health
研究领域[WOS]: Oncology ; Public, Environmental & Occupational Health
关键词[WOS]: RISK-FACTORS ; WOMEN ; METAANALYSIS ; NEOPLASIA ; INFECTION ; CARCINOMA ; PROVINCE
英文摘要:

Prophylactic vaccination against HPV 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [CIN)] 2/3) and ICC caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. To provide data for decisions on HPV vaccination in China, we determined HPV type-distribution in ICC and CIN 2/3 from women of different regions within China. A multicenter study was conducted by randomized sampling of paraffin blocks of 664 ICC (630 squamous cell carcinoma [SCC]; 34 adenocarcinoma [ADC]), 569 CIN 2/3 cases from seven regions of China. Histological diagnosis was confirmed in 1,233 cases by consensus review. HPV DNA was detected using the SPF10 LiPA25 version 1 assay. HPV prevalence was 97.6% in SCC, 85.3% in adenocarcinoma, and 98.9% in CIN 2/3. HPV 16 (76.7%) and HPV 18 (7.8%) were the most common, together accounting for 84.5% of SCC, followed by HPV 31 (3.2%), HPV 52 (2.2%), and HPV 58 (2.2%). HPV positivity in SCC did not differ notably by region. However, SCC cases from women <= 34 years had higher HPV 16 positivity than women over 50 years, among whom HPV 52, 58, and 39 were more common. HPV 16 and 18 were under-represented, whereas HPV 31, 52, and 58 were over-represented in CIN2/3 compared to SCC. The potential impact of vaccines against oncogenic HPV types 16 and 18 is estimated to be high (84.5%) against total SCC. These data are critical for China′s future evaluation of the cost-effectiveness of current cervical cancer vaccines and of HPV-based screening guidelines.

语种: 英语
项目资助者: GlaxoSmithKline Biologicals and Cancer Foundation of China
WOS记录号: WOS:000271198400018
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55792
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Dalian Med Univ, Affiliated Hosp 1, Dalian, Peoples R China
2.DDL Diagnost Lab, Voorburg, Netherlands
3.Zhengzhou Univ, Affiliated Hosp 2, Zhengzhou, Peoples R China
4.Liaoning Canc Hosp, Shenyang, Peoples R China
5.Univ Nottingham, Nottingham NG7 2RD, England
6.GlaxoSmithKline Biol, Rixensart, Belgium
7.Shaanxi Canc Hosp, Xian, Peoples R China
8.Chinese Acad Med Sci, Inst Canc, Beijing 100021, Peoples R China
9.Peking Union Med Coll, Sch Basic Med, Chinese Acad Med Sci, Inst Basic Med Sci, Beijing 100021, Peoples R China
10.Sun Yat Sen Univ, Canc Hosp, Guangzhou 510275, Guangdong, Peoples R China
11.Zhejiang Med Univ, Womens Hosp, Hangzhou, Zhejiang, Peoples R China
12.Xinjiang Peoples Hosp, Urumqi, Peoples R China
13.Sichuan Univ, Affiliated Hosp 2, Chengdu 610064, Peoples R China
14.Beijing Univ, Peoples Hosp, Beijing 100871, Peoples R China
15.Jiangxi Women & Childrens Hosp, Nanchang, Peoples R China
16.Hunan Peoples Hosp, Changsha, Hunan, Peoples R China
17.Gansu Women & Childrens Hosp, Lanzhou, Peoples R China
18.Chongqing Canc Hosp, Chongqing, Peoples R China
19.Gulou Hosp, Nanjing, Peoples R China
20.Guangxi Canc Hosp, Nanning, Peoples R China
21.Shenzhen Women & Childrens Hosp, Shenzhen, Peoples R China
22.Kunming Med Coll, Affiliated Hosp 2, Kunming, Peoples R China
23.China Japan Friendship Hosp, Beijing, Peoples R China
24.GlaxoSmithKline Biol, Singapore, Singapore
25.Univ N Carolina, Chapel Hill, NC USA

Recommended Citation:
Chen, Wen,Zhang, Xun,Molijn, Anco,et al. Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18[J]. CANCER CAUSES &amp; CONTROL,2009,20(9):1705-1713.
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