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学科主题基础医学
ApoA-II Directs Morphogenetic Movements of Zebrafish Embryo by Preventing Chromosome Fusion during Nuclear Division in Yolk Syncytial Layer
Zhang, Ting1; Yao, Shaohua1; Wang, Ping1; Yin, Chaoran1; Xiao, Chun1; Qian, Meilin1; Liu, Donghui2,3; Zheng, Lemin2,3; Meng, Wentong1; Zhu, Hongyan1; Liu, Jin1; Xu, Hong1; Mo, Xianming1
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2011-03-18
DOI10.1074/jbc.M110.134908
286期:11页:9514-9525
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]APOLIPOPROTEIN A-II ; EEL ANGUILLA-JAPONICA ; MYOCARDIAL MIGRATION ; INSULIN-RESISTANCE ; MULTIGENE FAMILY ; E GENE ; CELL ; EXPRESSION ; ORGANIZATION ; GASTRULATION
英文摘要

The high density lipoprotein (HDL) represents a class of lipid- and protein-containing particles and consists of two major apolipoproteins apoA-I and apoA-II. ApoA-II has been shown to be involved in the pathogenesis of insulin resistance, adiposity, diabetes, and metabolic syndrome. In embryo, apoa2 mRNAs are abundant in the liver, brain, lung, placenta, and in fish yolk syncytial layer (YSL), suggesting that apoa2 may perform a function during embryonic development. Here we find out that apoa2 modulates zebrafish embryonic development by regulating the organization of YSL. Disruption of apoa2 function in zebrafish caused chromosome fusing, which strongly blocked YSL nuclear division, inducing disorders in YSL organization and finally disturbing the embryonic epiboly. Purified native human apoA-II was able specifically to rescue the defects and induced nuclear division in zebrafish embryos and in human HeLa cells. The C terminus of apoA-II was required for the proper chromosome separation during nuclear division of YSL in zebrafish embryos and in human HeLa cells. Our data indicate that organization of YSL is required for blastoderm patterning and morphogenesis and suggest that apolipoprotein apoA-II is a novel factor of nuclear division in YSL involved in the regulation of early zebrafish embryonic morphogenesis and in mammalian cells for proliferation.

语种英语
WOS记录号WOS:000288247700078
项目编号2009CB941200 ; 30771228 ; 30771227
资助机构National Basic Research Program of China ; Nature Science Foundation of China
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被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55793
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Sichuan Univ, Lab Stem Cell Biol, State Key Lab Biotherapy, W China Hosp,W China Med Sch, Chengdu 610041, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Minist Educ, Inst Cardiovasc Sci, Beijing 100191, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
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Zhang, Ting,Yao, Shaohua,Wang, Ping,et al. ApoA-II Directs Morphogenetic Movements of Zebrafish Embryo by Preventing Chromosome Fusion during Nuclear Division in Yolk Syncytial Layer[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(11):9514-9525.
APA Zhang, Ting.,Yao, Shaohua.,Wang, Ping.,Yin, Chaoran.,Xiao, Chun.,...&Mo, Xianming.(2011).ApoA-II Directs Morphogenetic Movements of Zebrafish Embryo by Preventing Chromosome Fusion during Nuclear Division in Yolk Syncytial Layer.JOURNAL OF BIOLOGICAL CHEMISTRY,286(11),9514-9525.
MLA Zhang, Ting,et al."ApoA-II Directs Morphogenetic Movements of Zebrafish Embryo by Preventing Chromosome Fusion during Nuclear Division in Yolk Syncytial Layer".JOURNAL OF BIOLOGICAL CHEMISTRY 286.11(2011):9514-9525.
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