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学科主题: 基础医学
题名:
The functional regulation of TRPV1 and its role in pain sensitization
作者: Wang, Yun
关键词: TRPV1 ; PKD1 ; Cdk5 ; phosphorylation ; capsaicin analogues
刊名: NEUROCHEMICAL RESEARCH
发表日期: 2008-10-01
DOI: 10.1007/s11064-008-9750-5
卷: 33, 期:10, 页:2008-2012
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]: Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]: CYCLIN-DEPENDENT KINASE-5 ; PRIMARY SENSORY NEURONS ; NF-KAPPA-B ; PROTEIN-KINASE ; VANILLOID RECEPTOR ; HEAT HYPERALGESIA ; CAPSAICIN RECEPTOR ; DIRECT ACTIVATION ; PATHWAY ; RESINIFERATOXIN
英文摘要:

Transient receptor potential V1 (TRPV1) is specifically expressed in the nociceptive receptors and can detect a variety of noxious stimuli, thus potentiating pain sensitization. While peripheral delivery of capsaicin causes the desensitization of sensory neurons, thus alleviating pain. Therefore capsaicin is used in the clinical treatment of various types of pain; however, these treatments will bring many side effects, such as a strong burning pain in the early stages of treatment which hampers the further use of capsaicin. Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity. Thus we would summarize the progress of these two aspects in this mini review.

语种: 英语
所属项目编号: 30371635 ; 303330230 ; 30770703 ; 7072040 ; 20060001121
项目资助者: National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Doctoral Program of Higher Education
WOS记录号: WOS:000259190900013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55795
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Minist Educ & Hlth, Dept Neurobiol,Key Lab Neurosci, Beijing 100083, Peoples R China

Recommended Citation:
Wang, Yun. The functional regulation of TRPV1 and its role in pain sensitization[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2008-2012.
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