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学科主题基础医学
The functional regulation of TRPV1 and its role in pain sensitization
Wang, Yun
关键词Trpv1 Pkd1 Cdk5 Phosphorylation Capsaicin Analogues
刊名NEUROCHEMICAL RESEARCH
2008-10-01
DOI10.1007/s11064-008-9750-5
33期:10页:2008-2012
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Neurosciences
研究领域[WOS]Biochemistry & Molecular Biology ; Neurosciences & Neurology
关键词[WOS]CYCLIN-DEPENDENT KINASE-5 ; PRIMARY SENSORY NEURONS ; NF-KAPPA-B ; PROTEIN-KINASE ; VANILLOID RECEPTOR ; HEAT HYPERALGESIA ; CAPSAICIN RECEPTOR ; DIRECT ACTIVATION ; PATHWAY ; RESINIFERATOXIN
英文摘要

Transient receptor potential V1 (TRPV1) is specifically expressed in the nociceptive receptors and can detect a variety of noxious stimuli, thus potentiating pain sensitization. While peripheral delivery of capsaicin causes the desensitization of sensory neurons, thus alleviating pain. Therefore capsaicin is used in the clinical treatment of various types of pain; however, these treatments will bring many side effects, such as a strong burning pain in the early stages of treatment which hampers the further use of capsaicin. Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity. Thus we would summarize the progress of these two aspects in this mini review.

语种英语
WOS记录号WOS:000259190900013
项目编号30371635 ; 303330230 ; 30770703 ; 7072040 ; 20060001121
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Doctoral Program of Higher Education
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55795
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Minist Educ & Hlth, Dept Neurobiol,Key Lab Neurosci, Beijing 100083, Peoples R China
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GB/T 7714
Wang, Yun. The functional regulation of TRPV1 and its role in pain sensitization[J]. NEUROCHEMICAL RESEARCH,2008,33(10):2008-2012.
APA Wang, Yun.(2008).The functional regulation of TRPV1 and its role in pain sensitization.NEUROCHEMICAL RESEARCH,33(10),2008-2012.
MLA Wang, Yun."The functional regulation of TRPV1 and its role in pain sensitization".NEUROCHEMICAL RESEARCH 33.10(2008):2008-2012.
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