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学科主题: 基础医学
题名:
Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila
作者: Song, Qingxuan2; Sun, Kan2; Shuai, Yichun2; Lin, Ran3; You, Wenjia4; Wang, Lianzhang2; Zhong, Yi1,2
关键词: Suppressor of Hairless ; long-term memory ; Notch signaling ; mushroom bodies
刊名: JOURNAL OF NEUROGENETICS
发表日期: 2009
DOI: 10.3109/01677060903096133
卷: 23, 期:4, 页:405-411
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Neurosciences
研究领域[WOS]: Genetics & Heredity ; Neurosciences & Neurology
关键词[WOS]: NOTCH SIGNAL-TRANSDUCTION ; SPLIT COMPLEX GENES ; CONSOLIDATED MEMORY ; CRYSTAL-STRUCTURE ; MUSHROOM BODY ; CELL FATES ; BINDING ; ENHANCER ; DNA ; LOCALIZATION
英文摘要:

Suppressor of Hairless [Su(H)] is a DNA-binding protein of the Notch-signaling pathway, which is important for developmental processes and has been implicated in behavior plasticity. It. acts as a transcriptional activator in the Notch pathway, but also as a repressor in the absence of Notch signaling. Our previous work has shown that Notch signaling contributes to long-term memory formation in the Drosophila adult brain. In the present report, we show that Su(H) null heterozygous mutants perform normally for learning, early memory, and anesthesia-resistant memory, whereas long-term memory is impaired. Interestingly, we find overexpressing wild-type Su(H) also causes long-term memory defect in Drosophila. Significantly, induction of a heat-shock inducible Su(H)(+) transgene before training can fully rescue the memory defect of Su(H) mutants, thereby demonstrating an acute role for Su(H) in behavioral plasticity. We show that Su(H) is widely expressed in the adult. brain. Transgenic expression of wild-type Su(H) in the Mushroom Bodies is sufficient to rescue the memory defect of Su(H) mutants. Our data clearly demonstrate that transcriptional activity of Su(H) in Notch signaling in the mushroom bodies is critical for the formation of long-term memory.

语种: 英语
所属项目编号: 2006CB500800 ; 2009CB941301
项目资助者: Ministry of Science and Technology of China ; Tsinghua-Yue-Yuen Medical Sciences Fund
WOS记录号: WOS:000271470500005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55799
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
2.Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China

Recommended Citation:
Song, Qingxuan,Sun, Kan,Shuai, Yichun,et al. Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila[J]. JOURNAL OF NEUROGENETICS,2009,23(4):405-411.
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