IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila
Song, Qingxuan2; Sun, Kan2; Shuai, Yichun2; Lin, Ran3; You, Wenjia4; Wang, Lianzhang2; Zhong, Yi1,2
关键词Suppressor Of Hairless Long-term Memory Notch Signaling Mushroom Bodies
刊名JOURNAL OF NEUROGENETICS
2009
DOI10.3109/01677060903096133
23期:4页:405-411
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Neurosciences
研究领域[WOS]Genetics & Heredity ; Neurosciences & Neurology
关键词[WOS]NOTCH SIGNAL-TRANSDUCTION ; SPLIT COMPLEX GENES ; CONSOLIDATED MEMORY ; CRYSTAL-STRUCTURE ; MUSHROOM BODY ; CELL FATES ; BINDING ; ENHANCER ; DNA ; LOCALIZATION
英文摘要

Suppressor of Hairless [Su(H)] is a DNA-binding protein of the Notch-signaling pathway, which is important for developmental processes and has been implicated in behavior plasticity. It. acts as a transcriptional activator in the Notch pathway, but also as a repressor in the absence of Notch signaling. Our previous work has shown that Notch signaling contributes to long-term memory formation in the Drosophila adult brain. In the present report, we show that Su(H) null heterozygous mutants perform normally for learning, early memory, and anesthesia-resistant memory, whereas long-term memory is impaired. Interestingly, we find overexpressing wild-type Su(H) also causes long-term memory defect in Drosophila. Significantly, induction of a heat-shock inducible Su(H)(+) transgene before training can fully rescue the memory defect of Su(H) mutants, thereby demonstrating an acute role for Su(H) in behavioral plasticity. We show that Su(H) is widely expressed in the adult. brain. Transgenic expression of wild-type Su(H) in the Mushroom Bodies is sufficient to rescue the memory defect of Su(H) mutants. Our data clearly demonstrate that transcriptional activity of Su(H) in Notch signaling in the mushroom bodies is critical for the formation of long-term memory.

语种英语
WOS记录号WOS:000271470500005
项目编号2006CB500800 ; 2009CB941301
资助机构Ministry of Science and Technology of China ; Tsinghua-Yue-Yuen Medical Sciences Fund
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55799
专题北京大学基础医学院
作者单位1.Cold Spring Harbor Lab, Cold Spring Harbor, NY 11724 USA
2.Tsinghua Univ, Dept Biol Sci & Biotechnol, Beijing 100084, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, Beijing 100871, Peoples R China
4.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
推荐引用方式
GB/T 7714
Song, Qingxuan,Sun, Kan,Shuai, Yichun,et al. Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila[J]. JOURNAL OF NEUROGENETICS,2009,23(4):405-411.
APA Song, Qingxuan.,Sun, Kan.,Shuai, Yichun.,Lin, Ran.,You, Wenjia.,...&Zhong, Yi.(2009).Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila.JOURNAL OF NEUROGENETICS,23(4),405-411.
MLA Song, Qingxuan,et al."Suppressor of Hairless Is Required for Long-Term Memory Formation in Drosophila".JOURNAL OF NEUROGENETICS 23.4(2009):405-411.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Song, Qingxuan]的文章
[Sun, Kan]的文章
[Shuai, Yichun]的文章
百度学术
百度学术中相似的文章
[Song, Qingxuan]的文章
[Sun, Kan]的文章
[Shuai, Yichun]的文章
必应学术
必应学术中相似的文章
[Song, Qingxuan]的文章
[Sun, Kan]的文章
[Shuai, Yichun]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。