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Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model
Sun, Hongliang1; Xu, Linfeng1; Fan, Tianyuan2; Zhan, Hongzhi3; Wang, Xiaodong3; Zhou, Yanfei2; Yang, Ren-Jie3
关键词Hyperthermia Ferromagnetic Nanoparticles Lipiodol (r) Hepatocellular Carcinoma Animal Model
刊名INTERNATIONAL JOURNAL OF NANOMEDICINE
2013
DOI10.2147/IJN.S50373
8页:3795-3804
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Pharmacology & Pharmacy
研究领域[WOS]Science & Technology - Other Topics ; Pharmacology & Pharmacy
关键词[WOS]MAGNETIC FLUID HYPERTHERMIA ; MEDIATED HYPERTHERMIA ; CANCER
英文摘要

Background: The purpose of this study was to observe the effect and feasibility of hyperthermia and the influence of heat on surrounding organs in a VX2 rabbit liver model exposed to an alternating magnetic field after embolization with ferromagnetic nanoparticles.

Methods: Forty rabbits containing implanted hepatic VX2 carcinomas were divided into four groups, each containing ten rabbits. Fourteen days after tumor transplantation, we opened the abdomen to observe the size and shape of the tumor. A transfemoral retrograde approach was then used for hepatic arterial catheterization in groups B, C, and D to perform angiography and embolization. The next day, three rabbits in group B and all rabbits in group D were exposed to an alternating magnetic field, and the temperature was recorded simultaneously in the center of the tumor, at the edge of the tumor, and in the normal liver parenchyma. On day 28, all animals was euthanized to observe changes in the implanted liver tumor and the condition of the abdomen. A pathologic examination was also done.

Results: Before surgery, there was no significant difference in tumor volume between the four groups. Three different temperature points (cen-ter of the tumor, edge of the tumor, and in the normal liver parenchyma) of group B under an alternating magnetic field were 37.2 degrees C +/- 1.1 degrees C, 36.8 degrees C +/- 1.2 degrees C, and 36.9 degrees C +/- 2.1 degrees C, none of which were significantly different from pretreatment values. Three points basal temperature in group D showed no significant difference (F = 1.038, P = 0.413). Seven to 26 minutes after hyperthermia, the temperature at the center of the tumor and at the edge of the tumor in group D was significantly different from the corresponding points in group B and from normal liver tissue in group D (FB-D center = 5.431, PB-D center = 0.041, FB-Dedge = 9.744, PB-Dedge = 0.011; FD = 8.379, PD = 0.002). The highest temperature recorded at the rim of the tumor was 46 degrees C in group D. Fourteen days later, the tumor volume in the four groups was group A 31.4 +/- 20.6 cm(3), group B 26.7 +/- 18.2 cm(3), group C 28.7 +/- 9.1 cm(3), and group D 25.8 +/- 13.9 cm(3), with no significant difference found between the groups (F = 0.218, P = 0.883). The increase in tumor volume was greatest in group A and least in group D, while that in groups B and D was similar.

Conclusion: It is feasible to treat a VX2 tumor in an alternating magnetic field after embolization with magnetic nanoparticles without a significant effect on the surrounding normal liver parenchyma.

语种英语
WOS记录号WOS:000325062000001
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55801
专题北京大学药学院
北京大学药学院_药剂学系
作者单位1.Sun Yat Sen Univ, Sun Yat Sen Mem Hosp, Dept Intervent Therapy, Guangzhou 510275, Guangdong, Peoples R China
2.Beijing Univ, Sch Pharm, Beijing 100871, Peoples R China
3.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Dept Intervent Therapy, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Sun, Hongliang,Xu, Linfeng,Fan, Tianyuan,et al. Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model[J]. INTERNATIONAL JOURNAL OF NANOMEDICINE,2013,8:3795-3804.
APA Sun, Hongliang.,Xu, Linfeng.,Fan, Tianyuan.,Zhan, Hongzhi.,Wang, Xiaodong.,...&Yang, Ren-Jie.(2013).Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model.INTERNATIONAL JOURNAL OF NANOMEDICINE,8,3795-3804.
MLA Sun, Hongliang,et al."Targeted hyperthermia after selective embolization with ferromagnetic nanoparticles in a VX2 rabbit liver tumor model".INTERNATIONAL JOURNAL OF NANOMEDICINE 8(2013):3795-3804.
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