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Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique
Zhang, W. Q.; Yan, G. Z.; Ye, D. D.; Chen, C. W.
关键词Colonic Motility Constipation Telemetry
刊名PHYSIOLOGICAL MEASUREMENT
2007-02-01
DOI10.1088/0967-3334/28/2/003
28期:2页:141-148
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biophysics ; Engineering, Biomedical ; Physiology
研究领域[WOS]Biophysics ; Engineering ; Physiology
关键词[WOS]MOTOR-ACTIVITY ; HUMANS
英文摘要

Colonic motility disorders are common conditions. However, our understanding of normal and pathological motor functions of the colon remains limited, mainly due to the technical difficulties in accessing this organ for study. To investigate colonic motility under normal physiological conditions, we have developed a novel monitoring system based on a telemetry technique. The system is capable of prolonged and noninvasive measurement of intraluminal pressure changes and transit time of intra-colonic contents. To test the in vivo performance of the monitoring system, 15 healthy volunteers and 15 patients with functional constipation (FC) participated in this study. A single-use telemetry capsule embedded with sensors was ingested by the subjects. The capsule is capable of transmitting colonic pressure and temperature wirelessly. The time of the telemetry capsule entering the segmental colon was detected by ultrasonic detection of the batteries in capsule. Pressure recordings confirmed in general a circadian behavior of colonic motility, as well as its response to waking and meals. In the FC patients, the contractile response to morning awakening and meal ingestion was significantly lower compared to the controls. The transit time measured using this method agreed with the time calculated from radiopaque markers (r = 0.89, p < 0.05). The clinical study proved both the reliability and the noninvasiveness of the system. This capsule-style manometric system may represent a useful tool for the study of physiology and pathology of colonic motor disorders.

语种英语
WOS记录号WOS:000243750900003
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55802
专题北京大学第三临床医学院
作者单位1.Shanghai Jiao Tong Univ, Inst Med Precise Instrumentat, Shanghai 200240, Peoples R China
2.Peking Univ, Hosp 3, Dept Anorectol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhang, W. Q.,Yan, G. Z.,Ye, D. D.,et al. Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique[J]. PHYSIOLOGICAL MEASUREMENT,2007,28(2):141-148.
APA Zhang, W. Q.,Yan, G. Z.,Ye, D. D.,&Chen, C. W..(2007).Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique.PHYSIOLOGICAL MEASUREMENT,28(2),141-148.
MLA Zhang, W. Q.,et al."Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique".PHYSIOLOGICAL MEASUREMENT 28.2(2007):141-148.
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