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学科主题: 临床医学
题名:
Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique
作者: Zhang, W. Q.; Yan, G. Z.; Ye, D. D.; Chen, C. W.
关键词: colonic motility ; constipation ; telemetry
刊名: PHYSIOLOGICAL MEASUREMENT
发表日期: 2007-02-01
DOI: 10.1088/0967-3334/28/2/003
卷: 28, 期:2, 页:141-148
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Engineering, Biomedical ; Physiology
研究领域[WOS]: Biophysics ; Engineering ; Physiology
关键词[WOS]: MOTOR-ACTIVITY ; HUMANS
英文摘要:

Colonic motility disorders are common conditions. However, our understanding of normal and pathological motor functions of the colon remains limited, mainly due to the technical difficulties in accessing this organ for study. To investigate colonic motility under normal physiological conditions, we have developed a novel monitoring system based on a telemetry technique. The system is capable of prolonged and noninvasive measurement of intraluminal pressure changes and transit time of intra-colonic contents. To test the in vivo performance of the monitoring system, 15 healthy volunteers and 15 patients with functional constipation (FC) participated in this study. A single-use telemetry capsule embedded with sensors was ingested by the subjects. The capsule is capable of transmitting colonic pressure and temperature wirelessly. The time of the telemetry capsule entering the segmental colon was detected by ultrasonic detection of the batteries in capsule. Pressure recordings confirmed in general a circadian behavior of colonic motility, as well as its response to waking and meals. In the FC patients, the contractile response to morning awakening and meal ingestion was significantly lower compared to the controls. The transit time measured using this method agreed with the time calculated from radiopaque markers (r = 0.89, p < 0.05). The clinical study proved both the reliability and the noninvasiveness of the system. This capsule-style manometric system may represent a useful tool for the study of physiology and pathology of colonic motor disorders.

语种: 英语
WOS记录号: WOS:000243750900003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55802
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Inst Med Precise Instrumentat, Shanghai 200240, Peoples R China
2.Peking Univ, Hosp 3, Dept Anorectol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, W. Q.,Yan, G. Z.,Ye, D. D.,et al. Simultaneous assessment of the intraluminal pressure and transit time of the colon using a telemetry technique[J]. PHYSIOLOGICAL MEASUREMENT,2007,28(2):141-148.
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