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IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科  > 期刊论文
学科主题: 临床医学
题名:
ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS
作者: Deng, Chun-Yu1; Yu, Xi-Yong1; Kuang, Su-Juan1; Rao, Fang2; Yang, Min1; Shan, Zhi-Xin1; Qian, Wei-Min2; Zhou, Zhi-Ling1; Lin, Qiu-Xiong1; Wu, Shu-Lin2; Zhang, You-Yi3; Lin, Shu-Guang2
关键词: human atrial myocytes ; ion currents ; ketamine
刊名: CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
发表日期: 2008-12-01
DOI: 10.1111/j.1440-1681.2008.05012.x
卷: 35, 期:12, 页:1465-1470
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: RABBIT VENTRICULAR MYOCYTES ; GUINEA-PIG HEART ; INTRAVENOUS ANESTHETICS ; POTASSIUM CURRENTS ; PAPILLARY-MUSCLE ; IN-VITRO ; MYOCARDIUM ; RAT ; CONTRACTILITY ; MECHANISM
英文摘要:

1. Ketamine is widely used for the induction of anaesthesia in high-risk patients with cardiovascular instability or severe hypovolaemia. However, the ionic mechanisms involved in the effects of ketamine at therapeutically relevant concentrations in human cardiac myocytes are unclear. The present study was designed to investigate the effects of ketamine on L-type Ca(2+) (I(Ca)), transient outward K(+) (I(to)), ultra-rapid delayed rectifier K(+) (I(Kur)) and inward rectifier potassium (I(K1)) currents, as well as on action potentials, in human isolated atrial myocytes.

2. Atrial myocytes were isolated enzymatically from specimens of human atrial appendage obtained from patients undergoing coronary artery bypass grafting. The action potential and membrane currents were recorded in both current- and voltage-clamp modes using the patch-clamp technique.

3. Ketamine inhibited I(Ca) with an IC(50) of 1.8 mu mol/L. In addition, 10 mu mol/L ketamine decreased the I(Ca) peak current at +10 mV from 5.1 +/- 0.3 to 2.1 +/- 0.4 pA/pF (P < 0.01), but did not change the threshold potential, peak current potential and reverse potential.

4. Ketamine had no effect on I(to), I(Kur) or I(K1), but it reversibly shortened the duration of the action potential in human atrial myocytes.

5. In conclusion, ketamine, at a clinically relevant concentration, shortens the action potential duration of the human atrial myocytes, probably by inhibiting I(Ca).

语种: 英语
所属项目编号: 30772142 ; 30772620 ; 30672077 ; 2006CB503806 ; 015015
项目资助者: National Science Foundation of China ; National Key Basic Research Program (NKBRP) of China ; Team Program of Guangdong Provincial Science Foundation
WOS记录号: WOS:000260527500011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55803
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Guangdong Prov Peoples Hosp, Res Ctr Med Sci, Guangzhou 510080, Guangdong, Peoples R China
2.Guangdong Prov Cardiovasc Inst, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China

Recommended Citation:
Deng, Chun-Yu,Yu, Xi-Yong,Kuang, Su-Juan,et al. ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(12):1465-1470.
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