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学科主题临床医学
ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS
Deng, Chun-Yu1; Yu, Xi-Yong1; Kuang, Su-Juan1; Rao, Fang2; Yang, Min1; Shan, Zhi-Xin1; Qian, Wei-Min2; Zhou, Zhi-Ling1; Lin, Qiu-Xiong1; Wu, Shu-Lin2; Zhang, You-Yi3; Lin, Shu-Guang2
关键词Human Atrial Myocytes Ion Currents Ketamine
刊名CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY
2008-12-01
DOI10.1111/j.1440-1681.2008.05012.x
35期:12页:1465-1470
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy ; Physiology
研究领域[WOS]Pharmacology & Pharmacy ; Physiology
关键词[WOS]RABBIT VENTRICULAR MYOCYTES ; GUINEA-PIG HEART ; INTRAVENOUS ANESTHETICS ; POTASSIUM CURRENTS ; PAPILLARY-MUSCLE ; IN-VITRO ; MYOCARDIUM ; RAT ; CONTRACTILITY ; MECHANISM
英文摘要

1. Ketamine is widely used for the induction of anaesthesia in high-risk patients with cardiovascular instability or severe hypovolaemia. However, the ionic mechanisms involved in the effects of ketamine at therapeutically relevant concentrations in human cardiac myocytes are unclear. The present study was designed to investigate the effects of ketamine on L-type Ca(2+) (I(Ca)), transient outward K(+) (I(to)), ultra-rapid delayed rectifier K(+) (I(Kur)) and inward rectifier potassium (I(K1)) currents, as well as on action potentials, in human isolated atrial myocytes.

2. Atrial myocytes were isolated enzymatically from specimens of human atrial appendage obtained from patients undergoing coronary artery bypass grafting. The action potential and membrane currents were recorded in both current- and voltage-clamp modes using the patch-clamp technique.

3. Ketamine inhibited I(Ca) with an IC(50) of 1.8 mu mol/L. In addition, 10 mu mol/L ketamine decreased the I(Ca) peak current at +10 mV from 5.1 +/- 0.3 to 2.1 +/- 0.4 pA/pF (P < 0.01), but did not change the threshold potential, peak current potential and reverse potential.

4. Ketamine had no effect on I(to), I(Kur) or I(K1), but it reversibly shortened the duration of the action potential in human atrial myocytes.

5. In conclusion, ketamine, at a clinically relevant concentration, shortens the action potential duration of the human atrial myocytes, probably by inhibiting I(Ca).

语种英语
WOS记录号WOS:000260527500011
项目编号30772142 ; 30772620 ; 30672077 ; 2006CB503806 ; 015015
资助机构National Science Foundation of China ; National Key Basic Research Program (NKBRP) of China ; Team Program of Guangdong Provincial Science Foundation
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55803
专题北京大学第三临床医学院_心血管内科
作者单位1.Guangdong Prov Peoples Hosp, Res Ctr Med Sci, Guangzhou 510080, Guangdong, Peoples R China
2.Guangdong Prov Cardiovasc Inst, Dept Cardiol, Guangzhou, Guangdong, Peoples R China
3.Peking Univ, Hosp 3, Inst Vasc Med, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Deng, Chun-Yu,Yu, Xi-Yong,Kuang, Su-Juan,et al. ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS[J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,2008,35(12):1465-1470.
APA Deng, Chun-Yu.,Yu, Xi-Yong.,Kuang, Su-Juan.,Rao, Fang.,Yang, Min.,...&Lin, Shu-Guang.(2008).ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS.CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY,35(12),1465-1470.
MLA Deng, Chun-Yu,et al."ELECTROPHYSIOLOGICAL EFFECTS OF KETAMINE ON HUMAN ATRIAL MYOCYTES AT THERAPEUTICALLY RELEVANT CONCENTRATIONS".CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 35.12(2008):1465-1470.
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