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学科主题: 临床医学
题名:
Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles
作者: Huang, Jin; Lian, Ying; Qiao, Jie; Chen, Yongjian; Ren, Xiulian; Liu, Ping
关键词: preimplantation genetic diagnosis ; Robertsonian translocation ; blastocyst ; embryo development
刊名: PRENATAL DIAGNOSIS
发表日期: 2009-12-01
DOI: 10.1002/pd.2376
卷: 29, 期:12, 页:1167-1170
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]: Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]: IN-SITU HYBRIDIZATION ; BLASTOCYST STAGE ; FISH ANALYSIS ; CARRIERS ; SPERM ; SEGREGATION ; SPERMATOZOA ; MALES ; VITRO ; ABNORMALITIES
英文摘要:

Objective To explore the embryo development characteristics in Robertsonian translocations (RTs) in their preimplantation genetic diagnosis (PGD) cycles.

Method A total of 37 RT carrier Couples underwent 41 blastomere PGD cycles from August 2005 to September 2008. The development of 272 embryos was analyzed in their PGD cycles.

Result(s) At D3, there were 161 high-grade embryos, including 59 normal/balanced embryos and 102 abnormal embryos. There was no difference between the normal/balanced embryo group and the abnormal embryo group in terms of the high-grade embryo percentage (64.84% vs 56.35%, p = 0.179). However, at D5-D6 the blastocyst percentage in the normal/balanced embryo group was significantly higher than that in the abnormal embryo group (43.96% vs 20.44%, p = 0.000).

Conclusion(s) Normal/balanced embryos developed better and it self-selective mechanism may exist in the RTs′ embryos at the blastocyst formation stage. Copyright (C) 2009 John Wiley & Sons, Ltd.

语种: 英语
所属项目编号: 2007ZB948102 ; YZZ08-7-13
项目资助者: Nation Basic Research Program of China ; Seeds Fund of Peking University Third Hospital
WOS记录号: WOS:000272734700011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55805
Appears in Collections:北京大学第三临床医学院_生殖医学中心_期刊论文

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作者单位: Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China

Recommended Citation:
Huang, Jin,Lian, Ying,Qiao, Jie,et al. Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles[J]. PRENATAL DIAGNOSIS,2009,29(12):1167-1170.
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