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Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles
Huang, Jin; Lian, Ying; Qiao, Jie; Chen, Yongjian; Ren, Xiulian; Liu, Ping
关键词Preimplantation Genetic Diagnosis Robertsonian Translocation Blastocyst Embryo Development
刊名PRENATAL DIAGNOSIS
2009-12-01
DOI10.1002/pd.2376
29期:12页:1167-1170
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Genetics & Heredity ; Obstetrics & Gynecology
研究领域[WOS]Genetics & Heredity ; Obstetrics & Gynecology
关键词[WOS]IN-SITU HYBRIDIZATION ; BLASTOCYST STAGE ; FISH ANALYSIS ; CARRIERS ; SPERM ; SEGREGATION ; SPERMATOZOA ; MALES ; VITRO ; ABNORMALITIES
英文摘要

Objective To explore the embryo development characteristics in Robertsonian translocations (RTs) in their preimplantation genetic diagnosis (PGD) cycles.

Method A total of 37 RT carrier Couples underwent 41 blastomere PGD cycles from August 2005 to September 2008. The development of 272 embryos was analyzed in their PGD cycles.

Result(s) At D3, there were 161 high-grade embryos, including 59 normal/balanced embryos and 102 abnormal embryos. There was no difference between the normal/balanced embryo group and the abnormal embryo group in terms of the high-grade embryo percentage (64.84% vs 56.35%, p = 0.179). However, at D5-D6 the blastocyst percentage in the normal/balanced embryo group was significantly higher than that in the abnormal embryo group (43.96% vs 20.44%, p = 0.000).

Conclusion(s) Normal/balanced embryos developed better and it self-selective mechanism may exist in the RTs′ embryos at the blastocyst formation stage. Copyright (C) 2009 John Wiley & Sons, Ltd.

语种英语
WOS记录号WOS:000272734700011
项目编号2007ZB948102 ; YZZ08-7-13
资助机构Nation Basic Research Program of China ; Seeds Fund of Peking University Third Hospital
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55805
专题北京大学第三临床医学院_妇产科
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Ctr Reprod Med, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Huang, Jin,Lian, Ying,Qiao, Jie,et al. Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles[J]. PRENATAL DIAGNOSIS,2009,29(12):1167-1170.
APA Huang, Jin,Lian, Ying,Qiao, Jie,Chen, Yongjian,Ren, Xiulian,&Liu, Ping.(2009).Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles.PRENATAL DIAGNOSIS,29(12),1167-1170.
MLA Huang, Jin,et al."Characteristics of embryo development in Robertsonian translocations′ preimplantation genetic diagnosis cycles".PRENATAL DIAGNOSIS 29.12(2009):1167-1170.
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