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学科主题: 临床医学
题名:
Influence of brain-derived neurotrophic factor (Val66Met) genetic polymorphism on the ages of onset for heroin abuse in males
作者: Hou, Haifeng1; Qing, Zhirong2; Jia, Shaowei1; Zhang, Xu2; Hu, Su1; Hu, Jinsen1
关键词: Brain-derived neurotrophic factor (BDNF) ; Drug dependence ; Genetics ; Heroin ; Real-time PCR ; Single nucleotide polymorphism
刊名: BRAIN RESEARCH
发表日期: 2010-09-24
DOI: 10.1016/j.brainres.2010.07.022
卷: 1353, 页:245-248
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: VENTRAL TEGMENTAL AREA ; DRUG-USE ; SUBSTANCE-ABUSE ; BDNF ; ASSOCIATION ; ADDICTION ; ALCOHOL ; VULNERABILITY ; DEPENDENCE ; SMOKING
英文摘要:

Previous studies have shown that one of the genetic variants BDNF val66met polymorphism is associated with drug addiction. Age at onset for drugs abuse has also been regularly cited as a factor associated with high genetic predispositions. We conducted an exploratory research to investigate the association of BDNF val66met genetic polymorphism with the ages of onset for heroin abuse in males. Venous blood samples from 96 heroin-dependent persons were analyzed by Real-Time Fluorogenic PCR Assay to determine the genotype of BDNF val66met polymorphism. The effect of BDNF val66met genetic polymorphism on the age of onset for heroin abuse was analyzed in the patients of different genotypes. The observed genotype frequency was 32.29% (val66val; n=31), 45.83% (val66met; n=44), and 21.88% (met66met; n=21), which was similar with the reported results of Asians. The onset age was significantly different among the three genotypic groups, and val66met carriers had earlier onset of heroin abuse than did val66val and met66met carriers. Our findings further illustrate the role of BDNF genetic variants in drug abuse and dependence and this study will help to identify who are at risk of becoming heroin dependence in the future and decide the more appropriate timing that interventions should be taken in the high-risk groups. (C) 2010 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2008B090500129 ; 2004B36001075 ; 06027973 ; A2007592
项目资助者: Guangdong Science and Technology Department (Guangdong Province and Ministry of Education) ; Guangdong Province Science and Technology Research ; Guangdong Natural Science Fund Committee (Natural Science Foundation of Guangdong Province) ; Guangdong Health Department
WOS记录号: WOS:000282419500025
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55809
Appears in Collections:北京大学深圳医院_核医学科_期刊论文

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作者单位: 1.Mendel Genet Res Inst, Shanghai, Peoples R China
2.Peking Univ, Shenzhen Hosp, Dept Nucl Med, Shenzhen 518036, Peoples R China

Recommended Citation:
Hou, Haifeng,Qing, Zhirong,Jia, Shaowei,et al. Influence of brain-derived neurotrophic factor (Val66Met) genetic polymorphism on the ages of onset for heroin abuse in males[J]. BRAIN RESEARCH,2010,1353:245-248.
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