IR@PKUHSC  > 北京大学深圳医院
学科主题临床医学
Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice
Du, Jing1; Zhang, Jian2; Zou, Dexue1; Ye, Liang3; Chen, G. George2; Yang, Chao4
关键词Interleukin-10 Gene Deficiency Liver Function Inos Il-1 Beta
刊名CLINICAL AND EXPERIMENTAL MEDICINE
2015-08-01
DOI10.1007/s10238-014-0291-8
15期:3页:321-325
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]LIVER-DISEASE ; INJURY ; CELLS ; BILIRUBIN ; CYTOKINE ; ABSENCE ; IL-10
英文摘要

The aim of this study was to investigate the effect of interleukin-10 (IL-10) gene deficiency on mouse liver function. The experimental mice were divided into wild-type and IL-10 knockout groups. Serological biomarkers for liver functions were detected by the automatic biochemical analyzer AU5400. The pathological changes were assessed by the light microscope. The levels of inducible nitric oxide synthase (iNOS) and interleukin-1 beta (IL-1 beta) in liver tissues were determined by quantitative real-time PCR and enzyme-linked immunosorbent assay. Compared with the wild type, the serum levels of albumin (ALB), total protein, total bilirubin and direct bilirubin in IL-10-deficient mice were significantly decreased (P < 0.05). No obvious pathological changes including liver necrosis and inflammatory cell infiltration were found. The expression of iNOS and IL-1 beta genes, the serum levels of iNOS and IL-1 beta were significantly higher in IL-10-deficient mice than in wild-type mice (P < 0.05). The absence of IL-10 gene can significantly decrease serum ALB and bilirubin. The effect may be related to the upregulation of iNOS and IL-1 beta.

语种英语
WOS记录号WOS:000358775900011
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55810
专题北京大学深圳医院
作者单位1.Shenzhen Univ, Sch Med, Shenzhen 518036, Peoples R China
2.Shenzhen Peoples Hosp, Dept Surg, Shenzhen 518020, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Clin Lab Med, Shenzhen 518036, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China
推荐引用方式
GB/T 7714
Du, Jing,Zhang, Jian,Zou, Dexue,et al. Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice[J]. CLINICAL AND EXPERIMENTAL MEDICINE,2015,15(3):321-325.
APA Du, Jing,Zhang, Jian,Zou, Dexue,Ye, Liang,Chen, G. George,&Yang, Chao.(2015).Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice.CLINICAL AND EXPERIMENTAL MEDICINE,15(3),321-325.
MLA Du, Jing,et al."Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice".CLINICAL AND EXPERIMENTAL MEDICINE 15.3(2015):321-325.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Du, Jing]的文章
[Zhang, Jian]的文章
[Zou, Dexue]的文章
百度学术
百度学术中相似的文章
[Du, Jing]的文章
[Zhang, Jian]的文章
[Zou, Dexue]的文章
必应学术
必应学术中相似的文章
[Du, Jing]的文章
[Zhang, Jian]的文章
[Zou, Dexue]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。