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学科主题: 临床医学
题名:
Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice
作者: Du, Jing1; Zhang, Jian2; Zou, Dexue1; Ye, Liang3; Chen, G. George2; Yang, Chao4
关键词: Interleukin-10 gene deficiency ; Liver function ; iNOS ; IL-1 beta
刊名: CLINICAL AND EXPERIMENTAL MEDICINE
发表日期: 2015-08-01
DOI: 10.1007/s10238-014-0291-8
卷: 15, 期:3, 页:321-325
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: LIVER-DISEASE ; INJURY ; CELLS ; BILIRUBIN ; CYTOKINE ; ABSENCE ; IL-10
英文摘要:

The aim of this study was to investigate the effect of interleukin-10 (IL-10) gene deficiency on mouse liver function. The experimental mice were divided into wild-type and IL-10 knockout groups. Serological biomarkers for liver functions were detected by the automatic biochemical analyzer AU5400. The pathological changes were assessed by the light microscope. The levels of inducible nitric oxide synthase (iNOS) and interleukin-1 beta (IL-1 beta) in liver tissues were determined by quantitative real-time PCR and enzyme-linked immunosorbent assay. Compared with the wild type, the serum levels of albumin (ALB), total protein, total bilirubin and direct bilirubin in IL-10-deficient mice were significantly decreased (P < 0.05). No obvious pathological changes including liver necrosis and inflammatory cell infiltration were found. The expression of iNOS and IL-1 beta genes, the serum levels of iNOS and IL-1 beta were significantly higher in IL-10-deficient mice than in wild-type mice (P < 0.05). The absence of IL-10 gene can significantly decrease serum ALB and bilirubin. The effect may be related to the upregulation of iNOS and IL-1 beta.

语种: 英语
WOS记录号: WOS:000358775900011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55810
Appears in Collections:北京大学深圳医院_期刊论文

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作者单位: 1.Shenzhen Univ, Sch Med, Shenzhen 518036, Peoples R China
2.Shenzhen Peoples Hosp, Dept Surg, Shenzhen 518020, Peoples R China
3.Peking Univ, Shenzhen Hosp, Dept Clin Lab Med, Shenzhen 518036, Peoples R China
4.Chinese Univ Hong Kong, Prince Wales Hosp, Dept Surg, Shatin, Hong Kong, Peoples R China

Recommended Citation:
Du, Jing,Zhang, Jian,Zou, Dexue,et al. Effects of interleukin-10 gene deficiency on hepatic biochemical metabolism in mice[J]. CLINICAL AND EXPERIMENTAL MEDICINE,2015,15(3):321-325.
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