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学科主题基础医学
ATP Synthase beta-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level
Song, Kexiu1; Han, Yingchun2; Zhang, Linhua1; Liu, Guoqing; Yang, Peng1; Cheng, Xiaoyun1; Bu, Le1; Sheng, Hui1,3; Qu, Shen1,3
刊名INTERNATIONAL JOURNAL OF ENDOCRINOLOGY
2014
DOI10.1155/2014/356432
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]HIGH-DENSITY-LIPOPROTEIN ; SCAVENGER RECEPTOR BI ; REVERSE CHOLESTEROL TRANSPORT ; AORTIC ENDOTHELIAL-CELLS ; APOLIPOPROTEIN-A-I ; APOA-I ; CARDIOVASCULAR-DISEASE ; LIPID-METABOLISM ; TRANSGENIC MICE ; DEFICIENT MICE
英文摘要

HDL cholesterol is known to be inversely correlated with cardiovascular disease due to its diverse antiatherogenic functions. SR-BI mediates the selective uptake of HDL-C. SR-BI knockout diminishes but does not completely block the transport of HDL; other receptors may be involved. Ectopic ATP synthase beta-chain in hepatocytes has been previously characterized as an apoA-I receptor, triggering HDL internalization. This study was undertaken to identify the overexpression of ectopic ATP synthase beta-chain on DIL-HDL uptake in primary hepatocytes in vitro and on plasma HDL levels in SR-BI knockout mice. Human ATP synthase beta-chain cDNA was delivered to the mouse liver by adenovirus and GFP adenovirus as control. The adenovirus-mediated overexpression of beta-chain was identified at both mRNA and protein levels on mice liver and validated by its increasing of DiL-HDL uptake in primary hepatocytes. In response to hepatic overexpression of beta-chain, plasma HDL-C levels and cholesterol were reduced in SR-BI knockout mice, compared with the control. The present data suggest that ATP synthase beta-chain can serve as the endocytic receptor of HDL, and its overexpression can reduce plasma HDL-C.

语种英语
WOS记录号WOS:000339180400001
项目编号81070238 ; 11ZZ33 ; PJ1408400
资助机构National Natural Science Foundation of China ; Shanghai Education and Science Key Foundation ; Shanghai Pujiang Foundation
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被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/55811
专题北京大学基础医学院_心血管所
作者单位1.Tongji Univ, Shanghai Peoples Hosp 10, Dept Endocrinol, Shanghai 200072, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Key Lab Mol Cardiovasc Sci,Minist Educ, Beijing 100191, Peoples R China
3.Nanjing Med Univ, Nanjing 210029, Jiangsu, Peoples R China
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GB/T 7714
Song, Kexiu,Han, Yingchun,Zhang, Linhua,et al. ATP Synthase beta-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level[J]. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY,2014.
APA Song, Kexiu.,Han, Yingchun.,Zhang, Linhua.,Liu, Guoqing.,Yang, Peng.,...&Qu, Shen.(2014).ATP Synthase beta-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level.INTERNATIONAL JOURNAL OF ENDOCRINOLOGY.
MLA Song, Kexiu,et al."ATP Synthase beta-Chain Overexpression in SR-BI Knockout Mice Increases HDL Uptake and Reduces Plasma HDL Level".INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (2014).
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