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学科主题: 基础医学
题名:
Serum erythropoietin: a useful biomarker for coronary collateral development and potential target for therapeutic angiogenesis among the patients with coronary chronic total occlusion
作者: Xu, Weixian; Guo, Zhiguo; Mi, Lin; Wang, Guisong
关键词: Chronic total occlusions ; coronary artery disease ; coronary collateral development ; erythropoietin ; vascular endothelial growth factor
刊名: BIOMARKERS
发表日期: 2013-06-01
DOI: 10.3109/1354750X.2013.787459
卷: 18, 期:4, 页:343-348
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biotechnology & Applied Microbiology ; Toxicology
研究领域[WOS]: Biotechnology & Applied Microbiology ; Toxicology
关键词[WOS]: ACUTE MYOCARDIAL-INFARCTION ; ENDOTHELIAL GROWTH-FACTOR ; CARDIAC-FUNCTION ; TRIAL ; INTERVENTION ; ISCHEMIA ; PORCINE ; LEVEL ; PILOT
英文摘要:

The study was to investigate the association of endogenous erythropoietin (EPO) and coronary collateral development. Forty-nine patients (31 with chronic total occlusion (CTO), 18 with normal coronary artery) were consecutively enrolled. The serum EPO was positively related with Rentrop class. Increased serum EPO was one of the independent predictors of good collateral development (odds ratio 1.31; p = 0.025). A significantly positive correlation was seen between serum EPO and vascular endothelial growth factor (VEGF) levels (r = 0.96, p < 0.001). Circulatory EPO may be a useful biomarker for coronary collateral development and potential target for therapeutic angiogenesis in patients with CTO.

语种: 英语
所属项目编号: 81170179
项目资助者: Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry ; National Natural Science Foundation of China
WOS记录号: WOS:000319525700009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/55814
Appears in Collections:基础医学院_心血管所_期刊论文

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作者单位: Peking Univ, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Key Lab Mol Cardiovasc Sci, Dept Cardiol,Hosp 3,Minist Hlth,Minist Educ, Beijing 100191, Peoples R China

Recommended Citation:
Xu, Weixian,Guo, Zhiguo,Mi, Lin,et al. Serum erythropoietin: a useful biomarker for coronary collateral development and potential target for therapeutic angiogenesis among the patients with coronary chronic total occlusion[J]. BIOMARKERS,2013,18(4):343-348.
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